Darren Martin
@darrenmartin.bsky.social
One sublineage of the BA3.2's lurking in Australia also has a six nt deletion in this spot (one of the "QT" residues is gone) - seems kind've convergent @ryanhisner.bsky.social ?
November 23, 2025 at 9:05 PM
One sublineage of the BA3.2's lurking in Australia also has a six nt deletion in this spot (one of the "QT" residues is gone) - seems kind've convergent @ryanhisner.bsky.social ?
He seems pretty harmless to me. But maybe, like him, I'm just a dumbass, and you're right: we should all keep our big dumbass mouths shut and let the clever people do all the talking.
November 21, 2025 at 3:27 PM
He seems pretty harmless to me. But maybe, like him, I'm just a dumbass, and you're right: we should all keep our big dumbass mouths shut and let the clever people do all the talking.
Standouts for me are Tyler, King, Food for Thought and Madam Medusa. Even if you think you don't like reggae, or if you think that UB40 were too commercial, you should still be able to appreciate that these are pretty fucking good songs. I have a soft spot for One in Ten from Present Arms too.
October 25, 2025 at 8:31 PM
Standouts for me are Tyler, King, Food for Thought and Madam Medusa. Even if you think you don't like reggae, or if you think that UB40 were too commercial, you should still be able to appreciate that these are pretty fucking good songs. I have a soft spot for One in Ten from Present Arms too.
Wow - this is really cool. Love that you zoomed straight in on natural variants. Is there a firm estimate yet for the proportion of spontaneously arising mutations (i.e. non-natural variants) in these genes that are deleterious? In yeast generally, even synonymous subs are often deleterious, right?
October 25, 2025 at 7:56 PM
Wow - this is really cool. Love that you zoomed straight in on natural variants. Is there a firm estimate yet for the proportion of spontaneously arising mutations (i.e. non-natural variants) in these genes that are deleterious? In yeast generally, even synonymous subs are often deleterious, right?
If it wasn't for the blip in Jan 2024 I'd guess it might be something like a sexually transmitted frog, toad or fish picornavirus. Regardless, you should check the rRNA and see if you get an associated peak for some kind of animal rRNA at that time.
October 24, 2025 at 7:48 PM
If it wasn't for the blip in Jan 2024 I'd guess it might be something like a sexually transmitted frog, toad or fish picornavirus. Regardless, you should check the rRNA and see if you get an associated peak for some kind of animal rRNA at that time.
Do you really mean you're hearing Patrick Stewart? Sort of the same but maybe better? I'd just go with Laszlo though.
October 11, 2025 at 9:50 AM
Do you really mean you're hearing Patrick Stewart? Sort of the same but maybe better? I'd just go with Laszlo though.
I think this may be the one: patents.google.com/patent/US200...
US20090030925A1 - Clustering phylogenetic variation patterns
- Google Patents
Data clustering is described for determining related components of the data. In one example, information on biomolecules may be clustered into groups in which the biomolecular data in a clustered grou...
patents.google.com
September 29, 2025 at 5:56 PM
I think this may be the one: patents.google.com/patent/US200...
I vaguely recall that Microsoft's bioinformatics peeps in Seattle tried (maybe successfully - I don't even know/care) to patent phylogenetic tree construction about 20 years ago. Happy for Tableau to waste some money on stupid shit though.
September 29, 2025 at 10:12 AM
I vaguely recall that Microsoft's bioinformatics peeps in Seattle tried (maybe successfully - I don't even know/care) to patent phylogenetic tree construction about 20 years ago. Happy for Tableau to waste some money on stupid shit though.
but...but...but.... their moms must have taken Tylenol for them to have such obvious autism spectrum things going....right? Or am I just saying stupid things again?
September 23, 2025 at 4:44 PM
but...but...but.... their moms must have taken Tylenol for them to have such obvious autism spectrum things going....right? Or am I just saying stupid things again?
For me joining always types out as joing - ratio almost always types out as ration for me too BTW. I thought it was probably a "muscle memory" thing that has preserved some mistakes i commonly made while I was learning to type. Might just be dementia though.
September 17, 2025 at 2:44 PM
For me joining always types out as joing - ratio almost always types out as ration for me too BTW. I thought it was probably a "muscle memory" thing that has preserved some mistakes i commonly made while I was learning to type. Might just be dementia though.
..a game where, in reality, neither risks nor rewards are ever known with any degree of certainty, where over-promising is rewarded more than under-delivering is penalized (it is easy to make excuses for "risky" work failing), and where funders cannot tell how novel/boring eventual outputs are.
September 14, 2025 at 3:37 PM
..a game where, in reality, neither risks nor rewards are ever known with any degree of certainty, where over-promising is rewarded more than under-delivering is penalized (it is easy to make excuses for "risky" work failing), and where funders cannot tell how novel/boring eventual outputs are.
I am almost certain that whatever modest success I have had in science at a mid-tier-uni with almost no research funding has been contingent on so many of my peers doggedly sticking to the standard "best" career path strategies that have them pointlessly competing in the game you describe here...
September 14, 2025 at 3:27 PM
I am almost certain that whatever modest success I have had in science at a mid-tier-uni with almost no research funding has been contingent on so many of my peers doggedly sticking to the standard "best" career path strategies that have them pointlessly competing in the game you describe here...
I mean incomplete information games like this one: utopia-game.com where winning strategies vs ~1.5K opponents are almost never the standard "optimal" 1 vs 1 (or even 1 vs 25) strategies. The best strategies turn out to be those that most effectively exploit the strategic choices of the masses.
The World's longest-running MMORPG game.
Build, explore and research to increase your power. Deploy your armies, thieves and powerful magic to combat your opponents and bring them to their knees. Work with your team mates to maximize our kin...
utopia-game.com
September 14, 2025 at 3:21 PM
I mean incomplete information games like this one: utopia-game.com where winning strategies vs ~1.5K opponents are almost never the standard "optimal" 1 vs 1 (or even 1 vs 25) strategies. The best strategies turn out to be those that most effectively exploit the strategic choices of the masses.
Fun preprint - I love it. Besides multiple projects per person and lab halo-effects, there are large numbers of other meta-game-aware strategies that could seriously upend people playing the standard balance-the-risk-vs-reward game. Do either of you play any MMO strategy games?
September 14, 2025 at 3:12 PM
Fun preprint - I love it. Besides multiple projects per person and lab halo-effects, there are large numbers of other meta-game-aware strategies that could seriously upend people playing the standard balance-the-risk-vs-reward game. Do either of you play any MMO strategy games?
Maybe they're only clichés for really clever people like you? I like him. Seems like a good egg. Lovely voice too. Could listen to his audiobooks for hours on a long car trip (even stupid people don't read while driving). I'll stop doing that though if you think I'm tasteless. I want you to like me.
September 4, 2025 at 9:52 PM
Maybe they're only clichés for really clever people like you? I like him. Seems like a good egg. Lovely voice too. Could listen to his audiobooks for hours on a long car trip (even stupid people don't read while driving). I'll stop doing that though if you think I'm tasteless. I want you to like me.
Very cool. I have this nagging (and almost completely unfounded) suspicion that fungi love viruses, all eukaryote-infecting viruses initially evolved in fungi, and that, even today, fungi play an under-appreciated role as transmission vectors of viruses adapted to infecting other eukaryotes.
August 25, 2025 at 7:10 PM
Very cool. I have this nagging (and almost completely unfounded) suspicion that fungi love viruses, all eukaryote-infecting viruses initially evolved in fungi, and that, even today, fungi play an under-appreciated role as transmission vectors of viruses adapted to infecting other eukaryotes.
He is right, "something dark will happen to them anyway"
August 21, 2025 at 3:20 PM
He is right, "something dark will happen to them anyway"
Suckily? What! Who doesn't love a Nerd-fight? Nerds are so hot right now.
August 14, 2025 at 10:03 AM
Suckily? What! Who doesn't love a Nerd-fight? Nerds are so hot right now.
To me it seems the unie-hate is being driven by overly online fragile-ego politicians/industrialists who feel humiliated whenever filterless academic/basic scientists call them out on their short-term-gains-at-all-costs bullshit. Its clownish for people on both sides to now scapegoat the humanities.
August 14, 2025 at 9:50 AM
To me it seems the unie-hate is being driven by overly online fragile-ego politicians/industrialists who feel humiliated whenever filterless academic/basic scientists call them out on their short-term-gains-at-all-costs bullshit. Its clownish for people on both sides to now scapegoat the humanities.
Stephin Merritt (from the magnetic fields), Lisa O'Neill and Iggy Pop?
August 11, 2025 at 10:40 AM
Stephin Merritt (from the magnetic fields), Lisa O'Neill and Iggy Pop?
Lovely work - thank you. Did you consider codon-anticodon binding energy patterns? There are ~9 discreet-ish codon-anti-codon binding energy levels and we find some slight signal in virus genomes of synonymous nt subs that maintain binding energy being favored over those that do not.
August 9, 2025 at 3:01 PM
Lovely work - thank you. Did you consider codon-anticodon binding energy patterns? There are ~9 discreet-ish codon-anti-codon binding energy levels and we find some slight signal in virus genomes of synonymous nt subs that maintain binding energy being favored over those that do not.
...Although it is great that you do not know of any cruelty or mistreatment, it is naïve to think this doesn't happen and I very much doubt that you are unaware of any worthless badly planned/performed mammal experiments. Some always slip-through.
July 12, 2025 at 9:26 AM
...Although it is great that you do not know of any cruelty or mistreatment, it is naïve to think this doesn't happen and I very much doubt that you are unaware of any worthless badly planned/performed mammal experiments. Some always slip-through.
I'd have chosen a less propaganda-ish picture for this article - one that better reflects the reality of animal-units and the not-so-glamorous fates of all the animals that they house. People get really pissed off when you try cover-up the downsides of animal experimentation....
July 12, 2025 at 9:11 AM
I'd have chosen a less propaganda-ish picture for this article - one that better reflects the reality of animal-units and the not-so-glamorous fates of all the animals that they house. People get really pissed off when you try cover-up the downsides of animal experimentation....
IMHO most likely from an HIV infected human living somewhere in southern Africa with a chronic SC2 infection. If it is from an animal, I would guess it came from a chronically SC2-infected southern African urban vervet monkey co-infected with SIV-sgm (i.e. monkey HIV). All just guesses though.
July 4, 2025 at 9:07 AM
IMHO most likely from an HIV infected human living somewhere in southern Africa with a chronic SC2 infection. If it is from an animal, I would guess it came from a chronically SC2-infected southern African urban vervet monkey co-infected with SIV-sgm (i.e. monkey HIV). All just guesses though.