Daria Van Tyne
@dariavantyne.bsky.social
Microbiology, evolution, and bacteriophages. University of Pittsburgh School of Medicine.
Fabulous study - congrats!!
October 29, 2025 at 11:03 PM
Fabulous study - congrats!!
Also, check out Emma's blog post about the study here: communities.springernature.com/posts/surviv...
Survival of the Fittest: How bacteriocin production is driving a global shift in vancomycin-resistant Enterococcus faecium populations
communities.springernature.com
March 21, 2025 at 2:12 PM
Also, check out Emma's blog post about the study here: communities.springernature.com/posts/surviv...
Finally, we wondered whether the strain replacement we observed at our hospital was a widespread phenomenon by examining over 15,000 publicly available VREfm genomes. We found that what is happening at UPMC is also happening all over the world. Global genomic surveillance for the win!
March 21, 2025 at 1:46 PM
Finally, we wondered whether the strain replacement we observed at our hospital was a widespread phenomenon by examining over 15,000 publicly available VREfm genomes. We found that what is happening at UPMC is also happening all over the world. Global genomic surveillance for the win!
To test whether bacteriocin T8 could help VREfm colonize the intestine, we phoned a friend @joeyzacks.bsky.social. The Zackular lab performed a mouse colonization study, which showed that bacteriocin T8 provided a strong competitive advantage in the mammalian gut.
March 21, 2025 at 1:46 PM
To test whether bacteriocin T8 could help VREfm colonize the intestine, we phoned a friend @joeyzacks.bsky.social. The Zackular lab performed a mouse colonization study, which showed that bacteriocin T8 provided a strong competitive advantage in the mammalian gut.
We observed large-scale strain replacement just in the 6 years of our study, and Emma figured out that this was likely due to production of a bacteriocin called T8, which is carried on a plasmid, kills enterococci, and was previously studied as a probiotic for the treatment of intestinal dysbiosis.
March 21, 2025 at 1:46 PM
We observed large-scale strain replacement just in the 6 years of our study, and Emma figured out that this was likely due to production of a bacteriocin called T8, which is carried on a plasmid, kills enterococci, and was previously studied as a probiotic for the treatment of intestinal dysbiosis.
In this study, first author @emmamills1.bsky.social took all the genomes collected by EDS-HAT between 2017 and 2022 and asked a simple question: which VREfm lineages are prevalent in the population, and does their prevalence change over time? Spoiler alert: There were big changes!
March 21, 2025 at 1:46 PM
In this study, first author @emmamills1.bsky.social took all the genomes collected by EDS-HAT between 2017 and 2022 and asked a simple question: which VREfm lineages are prevalent in the population, and does their prevalence change over time? Spoiler alert: There were big changes!
We are fortunate to have access to VREfm genomes and isolates from EDS-HAT, a bacterial genome sequencing surveillance program that has been running @upmc.com for almost a decade. EDS-HAT was built to detect transmission (yay @sundermannaj.bsky.social!), but it also enables lots of other studies.
March 21, 2025 at 1:46 PM
We are fortunate to have access to VREfm genomes and isolates from EDS-HAT, a bacterial genome sequencing surveillance program that has been running @upmc.com for almost a decade. EDS-HAT was built to detect transmission (yay @sundermannaj.bsky.social!), but it also enables lots of other studies.