Dan Udwary
@danudwary.secondarymetabolism.com
Natural products biosynthesis and computational biologist at JGI. Host of http://naturalprodcast.com This is my personal account, not my employer's, and things I say or re-post are not representative of them, and maybe not even me.
It's a bad time to be a bleeding edge gamer, maybe. Everything coming out runs perfectly fine on my five year old 3070. Ray tracing would be nice, but very optional.
November 28, 2025 at 5:52 PM
It's a bad time to be a bleeding edge gamer, maybe. Everything coming out runs perfectly fine on my five year old 3070. Ray tracing would be nice, but very optional.
All good. I'm not going to sell you on one, but various Meta Quests should have some deals right now, and no PC needed (though you can connect it to a PC and play stuff through Steam, too). They're probably the best setup to jump straight in.
November 28, 2025 at 4:39 PM
All good. I'm not going to sell you on one, but various Meta Quests should have some deals right now, and no PC needed (though you can connect it to a PC and play stuff through Steam, too). They're probably the best setup to jump straight in.
They all have controllers, one for each hand. On a Quest, there are cameras and sensors all over the thing that track them. It works surprisingly well.
November 28, 2025 at 4:37 PM
They all have controllers, one for each hand. On a Quest, there are cameras and sensors all over the thing that track them. It works surprisingly well.
Pretty much any VR system.
November 28, 2025 at 4:23 PM
Pretty much any VR system.
Star Wars Sequel trilogy remake. Hell, maybe the Prequels, too.
November 25, 2025 at 9:55 PM
Star Wars Sequel trilogy remake. Hell, maybe the Prequels, too.
YMMV, but I find the Jimi Hendrix Blues album gets me through drudgery. It used to be my study album on repeat back in college, so any blues is a little Pavlovian for me at this point.
November 25, 2025 at 9:29 PM
YMMV, but I find the Jimi Hendrix Blues album gets me through drudgery. It used to be my study album on repeat back in college, so any blues is a little Pavlovian for me at this point.
I see what you did, there
November 25, 2025 at 5:17 PM
I see what you did, there
Hard to say. If the last 5 minutes didn't spark some interest, then maybe not. The second episode is more representative of what the other episodes have been, so far, though.
November 25, 2025 at 5:16 PM
Hard to say. If the last 5 minutes didn't spark some interest, then maybe not. The second episode is more representative of what the other episodes have been, so far, though.
To be fair, how would a man who worked as a television broadcaster for seven years know anything about how cameras work?
November 25, 2025 at 4:33 PM
To be fair, how would a man who worked as a television broadcaster for seven years know anything about how cameras work?
Yes. There was a period in the 70s-90s where you could get solid funding from NIH for compound discovery. That kind of dried up completely by the 2000s with industry's move to combichem and NIH's push to translational. Right when I was looking for grants as an academic PI 🙄
November 25, 2025 at 4:10 PM
Yes. There was a period in the 70s-90s where you could get solid funding from NIH for compound discovery. That kind of dried up completely by the 2000s with industry's move to combichem and NIH's push to translational. Right when I was looking for grants as an academic PI 🙄
All correct. I'd also add that there was an intention that smaller companies from academic spinouts would be better suited to finding initial leads and then big companies would buy them up. That hasn't really happened either, for a lot of reasons.
November 25, 2025 at 4:02 PM
All correct. I'd also add that there was an intention that smaller companies from academic spinouts would be better suited to finding initial leads and then big companies would buy them up. That hasn't really happened either, for a lot of reasons.
Hey, I am that friend! :D
November 25, 2025 at 3:59 PM
Hey, I am that friend! :D
No, no, no. This is totally different. This uses "AI"!
November 25, 2025 at 3:37 PM
No, no, no. This is totally different. This uses "AI"!
But it can do 5 *different* reactions!
"The platform supports five core reaction types—reductive amination, Buchwald-Hartwig amination, Suzuki-Miyaura coupling, amide coupling, and acylation"
"The platform supports five core reaction types—reductive amination, Buchwald-Hartwig amination, Suzuki-Miyaura coupling, amide coupling, and acylation"
November 25, 2025 at 3:27 PM
But it can do 5 *different* reactions!
"The platform supports five core reaction types—reductive amination, Buchwald-Hartwig amination, Suzuki-Miyaura coupling, amide coupling, and acylation"
"The platform supports five core reaction types—reductive amination, Buchwald-Hartwig amination, Suzuki-Miyaura coupling, amide coupling, and acylation"
The Genesis mission is what killed Spock, so, yeah. Kinda.
November 25, 2025 at 12:59 AM
The Genesis mission is what killed Spock, so, yeah. Kinda.
I thought I was supposed to marry the four armed blue puppet with the moon goddess's soul? Because she gave me a nice sword.
November 24, 2025 at 3:52 PM
I thought I was supposed to marry the four armed blue puppet with the moon goddess's soul? Because she gave me a nice sword.
Yup. They're teenagers! You give them ninja weapons and then expect good choices? wtf!
FWIW, the newer animated movie did a pretty good job of capturing that.
FWIW, the newer animated movie did a pretty good job of capturing that.
November 23, 2025 at 4:24 PM
Yup. They're teenagers! You give them ninja weapons and then expect good choices? wtf!
FWIW, the newer animated movie did a pretty good job of capturing that.
FWIW, the newer animated movie did a pretty good job of capturing that.
Yeah... I made it through like half an episode. It seemed like a good premise when I first heard about it.
November 21, 2025 at 11:45 PM
Yeah... I made it through like half an episode. It seemed like a good premise when I first heard about it.
I get it. Fwiw, I don't use or even see the llm stuff. It's very easy to turn off and choose to not pay for, and they don't push it in your face. For me, it's literally a drop-in Google replacement in Firefox, and worth it to me. Ymmv
November 21, 2025 at 5:39 PM
I get it. Fwiw, I don't use or even see the llm stuff. It's very easy to turn off and choose to not pay for, and they don't push it in your face. For me, it's literally a drop-in Google replacement in Firefox, and worth it to me. Ymmv
It uses Google search APIs, so it's a Google search, just stripped of all the other bullshit. It's the best use of $10 a month I can imagine, if you're on the internet all day. I've never touched duckduckgo, so can't directly compare.
November 21, 2025 at 4:24 PM
It uses Google search APIs, so it's a Google search, just stripped of all the other bullshit. It's the best use of $10 a month I can imagine, if you're on the internet all day. I've never touched duckduckgo, so can't directly compare.