Dan Nomura
@dannomura.bsky.social
Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley
I rarely get to give a research talk at my home institution! Looking forward to giving a talk about our latest research next Tuesday, November 18th, at 2 pm as part of the @innovativegenomics.bsky.social seminar series in Room 115 IGIB at UC Berkeley! innovativegenomics.org/events/semin...
Reimagining Druggability using Chemoproteomic Platforms
Reimagining Druggability using Chemoproteomic Platforms - Innovative Genomics Institute (IGI)
innovativegenomics.org
November 11, 2025 at 6:18 PM
I rarely get to give a research talk at my home institution! Looking forward to giving a talk about our latest research next Tuesday, November 18th, at 2 pm as part of the @innovativegenomics.bsky.social seminar series in Room 115 IGIB at UC Berkeley! innovativegenomics.org/events/semin...
Reposted by Dan Nomura
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery
Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...
nature.com
November 4, 2025 at 4:12 PM
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
New from the Cravatt Lab!
Tryptoline stereoprobes reveal hidden cysteine ligandability: while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones.
A masterpiece of chemoproteomics + AI.
🔗 doi.org/10.1101/2025...
Tryptoline stereoprobes reveal hidden cysteine ligandability: while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones.
A masterpiece of chemoproteomics + AI.
🔗 doi.org/10.1101/2025...
Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex
Activity-based protein profiling has identified hundreds of proteins from diverse classes that react at specific cysteine residues with stereochemically defined electrophilic compounds (stereoprobes) ...
doi.org
October 22, 2025 at 7:12 PM
New from the Cravatt Lab!
Tryptoline stereoprobes reveal hidden cysteine ligandability: while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones.
A masterpiece of chemoproteomics + AI.
🔗 doi.org/10.1101/2025...
Tryptoline stereoprobes reveal hidden cysteine ligandability: while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones.
A masterpiece of chemoproteomics + AI.
🔗 doi.org/10.1101/2025...
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Targeted Transcriptional Repression by Induced Proximity
Most cancer driving proteins remain undruggable due to the absence of ligandable pockets and their reliance on intrinsically disordered or protein-DNA/protein-protein interactions. Transcription facto...
www.biorxiv.org
October 22, 2025 at 7:11 PM
We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Looking forward to seeing friends and giving a talk about our latest research at @stanfordchemistry.bsky.social @stanforduniversity.bsky.social tomorrow! chemistry.stanford.edu/events/chemi...
Chemical Biology Seminar: Professor Dan Nomura, University of California, Berkeley | Chemistry
About the Seminar "Reimagining Druggability using Chemoproteomic Platforms"The Nomura Research Group is focused on reimagining druggability using chemoproteomic platforms to develop transformative med...
chemistry.stanford.edu
September 29, 2025 at 6:17 PM
Looking forward to seeing friends and giving a talk about our latest research at @stanfordchemistry.bsky.social @stanforduniversity.bsky.social tomorrow! chemistry.stanford.edu/events/chemi...
We’re happy to highlight our newest
@biorxivpreprint.bsky.social by postdoc Thang Cong Do and Octant on the discovery of a direct-acting, covalent destabilizing degrader of immune & cancer transcription factors IRF8 & IRF5! Also thanks to @themarkfdn.bsky.social ! www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social by postdoc Thang Cong Do and Octant on the discovery of a direct-acting, covalent destabilizing degrader of immune & cancer transcription factors IRF8 & IRF5! Also thanks to @themarkfdn.bsky.social ! www.biorxiv.org/content/10.1...
Covalent Degraders of Immune Regulatory Transcription Factors IRF8 and IRF5
Transcription factors are among the most challenging targets for drug discovery due to their lack of classical binding pockets and high degree of intrinsic disorder, despite the therapeutic importance...
www.biorxiv.org
August 4, 2025 at 3:05 PM
We’re happy to highlight our newest
@biorxivpreprint.bsky.social by postdoc Thang Cong Do and Octant on the discovery of a direct-acting, covalent destabilizing degrader of immune & cancer transcription factors IRF8 & IRF5! Also thanks to @themarkfdn.bsky.social ! www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social by postdoc Thang Cong Do and Octant on the discovery of a direct-acting, covalent destabilizing degrader of immune & cancer transcription factors IRF8 & IRF5! Also thanks to @themarkfdn.bsky.social ! www.biorxiv.org/content/10.1...
This paper now out in ACS Central Science!! pubs.acs.org/doi/10.1021/...
June 27, 2025 at 5:35 AM
This paper now out in ACS Central Science!! pubs.acs.org/doi/10.1021/...
Awesome to be back in Cambridge for #ChemBiointhePub ahead of the Bioorganic Chemistry GRC!
June 13, 2025 at 4:31 AM
Awesome to be back in Cambridge for #ChemBiointhePub ahead of the Bioorganic Chemistry GRC!
Our latest paper w/ @pottslab.bsky.social & @amgen.bsky.social in @jacs.acspublications.org by co-first authors @cmzammit.bsky.social & Cory Nadel on discovery of covalent destabilizing degrader of AR & AR-V7 in prostate cancer. Thanks also to @themarkfdn.bsky.social ! pubs.acs.org/doi/10.1021/...
June 10, 2025 at 4:26 AM
Our latest paper w/ @pottslab.bsky.social & @amgen.bsky.social in @jacs.acspublications.org by co-first authors @cmzammit.bsky.social & Cory Nadel on discovery of covalent destabilizing degrader of AR & AR-V7 in prostate cancer. Thanks also to @themarkfdn.bsky.social ! pubs.acs.org/doi/10.1021/...
Reposted by Dan Nomura
Excited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen.
#MTI #Amgen #Biotech #UCB
#MTI #Amgen #Biotech #UCB
June 8, 2025 at 12:27 AM
Reposted by Dan Nomura
Bioorganic GRC is set! I got tired of the lack of swag so made a couple of unofficial tees. Order one if you want to support the conference (or simply enjoy strange looks in grocery stores).
Spirit: chembio-shop.fourthwall.com/products/grc...
World Tour: chembio-shop.fourthwall.com/products/spi...
Spirit: chembio-shop.fourthwall.com/products/grc...
World Tour: chembio-shop.fourthwall.com/products/spi...
Spirit
Preliminary score: ND
chembio-shop.fourthwall.com
June 3, 2025 at 3:16 AM
Bioorganic GRC is set! I got tired of the lack of swag so made a couple of unofficial tees. Order one if you want to support the conference (or simply enjoy strange looks in grocery stores).
Spirit: chembio-shop.fourthwall.com/products/grc...
World Tour: chembio-shop.fourthwall.com/products/spi...
Spirit: chembio-shop.fourthwall.com/products/grc...
World Tour: chembio-shop.fourthwall.com/products/spi...
Reposted by Dan Nomura
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced
forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 6:02 PM
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Congrats to chem bio grad students Ellie King, Lauren Orr, and Vienna Thomas on graduating with their PhD's!
May 19, 2025 at 8:49 PM
Congrats to chem bio grad students Ellie King, Lauren Orr, and Vienna Thomas on graduating with their PhD's!
Reposted by Dan Nomura
- Mutations mimicking glues by @brianliau.bsky.social al and Ning Zheng
- Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social
- And finish it of with a discussion on general mode-of-action.
- Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social
- And finish it of with a discussion on general mode-of-action.
May 8, 2025 at 9:27 AM
- Mutations mimicking glues by @brianliau.bsky.social al and Ning Zheng
- Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social
- And finish it of with a discussion on general mode-of-action.
- Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social
- And finish it of with a discussion on general mode-of-action.
Reposted by Dan Nomura
Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular basis of SIFI activity in the integrated stress response - Nature
Nature - Molecular basis of SIFI activity in the integrated stress response
www.nature.com
May 7, 2025 at 10:27 AM
Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dan Nomura
New-preprint alert! We use chemoproteomic profiling to show MYST KAT inhibitors exhibit hierarchical target engagement (KAT6A/B > KAT7 >> KAT8). Reminiscent of Type I kinase inhibitors, the selectivity of these small molecules varies based on concentration.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 4, 2025 at 2:22 PM
New-preprint alert! We use chemoproteomic profiling to show MYST KAT inhibitors exhibit hierarchical target engagement (KAT6A/B > KAT7 >> KAT8). Reminiscent of Type I kinase inhibitors, the selectivity of these small molecules varies based on concentration.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...
www.biorxiv.org
April 26, 2025 at 1:14 PM
Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dan Nomura
On my way to #aacr25. I’ll be chairing Part 3 of “Chemistry to the Clinic” tomorrow (4/26 at 2:30) with talks from @dannomura.bsky.social and @xiaoyuzhang.bsky.social. Weather report calls for lots of chemoproteomics, molecular glues, and tough targets. Please join us!
April 26, 2025 at 12:01 AM
On my way to #aacr25. I’ll be chairing Part 3 of “Chemistry to the Clinic” tomorrow (4/26 at 2:30) with talks from @dannomura.bsky.social and @xiaoyuzhang.bsky.social. Weather report calls for lots of chemoproteomics, molecular glues, and tough targets. Please join us!
Excited to moderate a panel at the @theaacr.bsky.social CICR townhall at #2025AACR on "Charting the Course: Innovating Cancer Drug Discovery in a Challenging Landscape" alongside Shiva Malek, Gwenn Hansen, Ryan Schoenfeld, and Joseph Pearlberg!
April 26, 2025 at 2:30 AM
Excited to moderate a panel at the @theaacr.bsky.social CICR townhall at #2025AACR on "Charting the Course: Innovating Cancer Drug Discovery in a Challenging Landscape" alongside Shiva Malek, Gwenn Hansen, Ryan Schoenfeld, and Joseph Pearlberg!
Back in Chicago for #2025AACR! I’ll be giving a talk on our latest work tomorrow in the Educational Session on Advances in Ligand Discovery to Enable Previously Intractable Targets on Sat Apr 26th 2:30-4:00pm in S406 McCormick South alongside @michael-erb.bsky.social & @xiaoyuzhang.bsky.social !
April 26, 2025 at 2:23 AM
Back in Chicago for #2025AACR! I’ll be giving a talk on our latest work tomorrow in the Educational Session on Advances in Ligand Discovery to Enable Previously Intractable Targets on Sat Apr 26th 2:30-4:00pm in S406 McCormick South alongside @michael-erb.bsky.social & @xiaoyuzhang.bsky.social !
Amazing talk yesterday by @rushika-perera.bsky.social for our Molecular Therapeutics seminar series!
April 25, 2025 at 6:02 PM
Amazing talk yesterday by @rushika-perera.bsky.social for our Molecular Therapeutics seminar series!
Had such an awesome time at @themarkfdn.bsky.social symposium today!!
Great afternoon of talks by @dannomura.bsky.social, Jeff Rathmell, Jun Wang, and Cathy Wu on reimagining druggability, the impact of obesity on immunotherapy response, antigen presentation inhibitors, & neoantigen discovery. That’s a wrap on #MarkSymposium 2025 – thanks for following along!
April 3, 2025 at 10:03 PM
Had such an awesome time at @themarkfdn.bsky.social symposium today!!
Amazing Quality Control Life Processes conference in Frankfurt organized by @idikic.bsky.social !! Great science, great friends!
March 27, 2025 at 12:28 PM
Amazing Quality Control Life Processes conference in Frankfurt organized by @idikic.bsky.social !! Great science, great friends!