🚨 New paper in @jclinical-invest.bsky.social!

Kidney lymphatics are a promising target in transplant rejection

🗺️ In rejection, lymphatics expand and adversely remodel

⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system

www.jci.org/articles/vie...

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We found that the kidney microvasculature in humans with PKD has a unique molecular fingerprint. In mice, abnormalities of the kidney microvasculature occurred early (like the striking results in this image). Importantly, these changes occurred before irreversible damage set in (4/5)

Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal!

doi.org/10.1242/dmm....

We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)