🧵 Work with Kosuke Seki, Amy Guo, Eleanor Zhu, Mark Kelly, and Tanja Kortemme

🧵 Our "Top0" design (0% seq. id. to Top7) is soluble, monomeric, folded, and the HSQC spectrum reveals that "Top0" likely maintains a fold identical to Top7!

🧵 We design and test novel proteins for de novo backbones. Most significantly, we evaluate a 0% sequence identity design for the famous Top7 fold

🧵 Frame2seq is an IPA-based encoder-only model that achieves state-of-the-art native sequence recovery