Danielle Bianchi
@daaninthelab.bsky.social
PhD student in the Brummelkamp lab at the Netherlands Cancer Institute.
Passionate about science and sarcasm. 🏳️🌈
Passionate about science and sarcasm. 🏳️🌈
Pinned
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
www.science.org
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Reposted by Danielle Bianchi
Scientists at the NKI have made a remarkable discovery: a new protein duo that can turn genes on and off. They have named this duo Zincore. Together, these proteins help other proteins bind more firmly to the DNA, allowing them to perform their functions more effectively www.nki.nl/news-events/...
July 10, 2025 at 1:38 PM
Scientists at the NKI have made a remarkable discovery: a new protein duo that can turn genes on and off. They have named this duo Zincore. Together, these proteins help other proteins bind more firmly to the DNA, allowing them to perform their functions more effectively www.nki.nl/news-events/...
Reposted by Danielle Bianchi
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
July 9, 2025 at 10:43 PM
🚀 My first Cryo-EM structures are OUT on the PDB!
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌
🔁Thank you for sharing!❤️
Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...
⬇️ 2nd video
Reposted by Danielle Bianchi
📢 Ready for this? A new way to think about Gene Regulation!
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
July 8, 2025 at 11:18 AM
📢 Ready for this? A new way to think about Gene Regulation!
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬
💪Proud to be part of this work led by @daaninthelab.bsky.social
Read more: science.org/doi/10.1126/science.adv2861
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...
www.science.org
July 4, 2025 at 11:00 AM
In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11