Cell Stem Cell
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Cell Stem Cell publishes research and reviews at the forefront of stem cell biology, bioengineering, and regenerative medicine. Posts by Cell Stem Cell editors.
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Our latest issue is out! Highlights include reports on the immune response to allogeneic cell therapies in clinical trials with iPS-DA neurons and primary hypoimmune CAR-T cells, a PDAC organoid biobank that IDed use of statins in a clinical trial, & more! www.cell.com/cell-stem-ce...
Online Now! Space-associated stem cell hallmarks of aging and resilience in astronauts #stemcells
Space-associated stem cell hallmarks of aging and resilience in astronauts
Hematopoietic stem and progenitor cell functionally organized multi-omics aging and resilience (HSPC-FOMA-R) analyses of 9 astronauts before, during, and after ISS missions revealed hallmarks of accelerated aging, including reduced self-renewal and telomere maintenance, mitochondrial dysfunction, and genomic instability with clonal mutations together with cytokine and retrotransposon deregulation.
dlvr.it
November 25, 2025 at 12:36 AM
Online Now! Space-associated stem cell hallmarks of aging and resilience in astronauts #stemcells
Online Now! Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells #stemcells
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif et al. show that lysosomes in aged HSCs are hyperacidic and dysfunctional, and that lysosomal alterations are central to HSCs’ decline with age. cGAS-STING signaling, driven by misprocessed mtDNA, mediates inflammation in old HSCs. Notably, inhibition of v-ATPases restores lysosomal integrity, reduces inflammation, and improves aged HSCs’ function.
dlvr.it
November 24, 2025 at 8:09 PM
Online Now! Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells #stemcells
Online Now! Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids #stemcells
Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids
Li et al. present a 3D in vitro bone marrow model that faithfully captures phenotypic, structural, and functional features of human endosteal bone marrow niches, enabling the study of pathophysiological interactions between hematopoietic stem and progenitor cells and their microenvironment in fully human settings.
dlvr.it
November 18, 2025 at 8:09 PM
Online Now! Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids #stemcells
Online Now! Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages #stemcells
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages
Zeng and colleagues identify Clu+ cardiomyocytes as key regenerative drivers that orchestrate a cardio-immune circuit to resolve inflammation and promote CM proliferation, highlighting CLU as a therapeutic target and offering translational insights for myocardial infarction repair in adults.
dlvr.it
November 11, 2025 at 12:36 AM
Online Now! Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages #stemcells
Boosting dopamine: Following the lineage toward Parkinson’s repair
Boosting dopamine: Following the lineage toward Parkinson’s repair
Low yields of dopamine neurons in human stem cell-derived neural grafts limit their potential for treating Parkinson’s disease. Zhang et al. develop a new three-dimensional differentiation method, informed and refined through careful clonal linage tracing of donor cells post-transplantation, to improve dopamine neuron purity of grafts, eliminating unwanted, off-target populations.
dlvr.it
November 10, 2025 at 8:09 PM
Boosting dopamine: Following the lineage toward Parkinson’s repair
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial
The number of RPE transplantation clinical trials for dry AMD is increasing quickly, with groups using different stem cell sources, delivery approaches, and immune suppression. We discuss the recent success in a phase 1/2a clinical trial evaluating allogeneic RPE stem cell-derived RPE cells isolated from the RPE layer of human cadaveric eyes.
dlvr.it
November 10, 2025 at 3:11 PM
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
Tang and colleagues dissect cellular contributions and interplay among fibroblasts, epithelial progenitors, immune components, and vasculature in both regenerative and fibrotic responses to tissue injury. They also examine therapeutic strategies that navigate the complexities of immune mediators, fibrogenic myofibroblasts, and excess ECM with small-molecule targeting and various cell-based approaches.
dlvr.it
November 10, 2025 at 12:45 PM
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells
Zhu and colleagues reported that METTL3 inhibition in naive hESCs upregulated 8C-associated transcripts, including LTRs, and promoted chromatin opening. Reducing m6A on primate-specific L1PA mimicked this transcriptome transition, influencing LTR binding and protein preferences for L1-mediated chromatin recruitment, particularly suppressing EP300 binding to ERV1 and enhancing KAP1 binding to ERVL-MaLR.
dlvr.it
November 8, 2025 at 12:36 AM
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate cardiac development and conduction and, under chronic inflammation, recapitulate atrial fibrillation features, offering a powerful model to study immune-cardiac interactions and arrhythmia mechanisms.
dlvr.it
November 7, 2025 at 8:09 PM
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy
Chen and colleagues present a 3D differentiation method for the efficient and robust generation of mDAP-enriched donor cells from hPSCs. They mapped the clonal lineages between donor cells and their derivatives within grafts following transplantation, which facilitates further refinement of the differentiation method and the elimination of off-target lineage cells.
dlvr.it
November 7, 2025 at 3:10 PM
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming
Zeng et al. identify EZHIP as a critical epigenetic reprogramming factor in mouse early embryos, which promotes global erasure, intergenerational inheritance, and re-establishment of H3K27me3. They demonstrate that without EZHIP restriction, hyperactive PRC2 deposits promiscuous H3K27me3 across the genome, which paradoxically causes loss of H3K27me3-mediated imprinting memories and gene repression.
dlvr.it
November 7, 2025 at 12:46 PM
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming
Vitamin C conveys geroprotection on primate ovaries
Vitamin C conveys geroprotection on primate ovaries
Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles. These geroprotective effects are partially mediated through NRF2 pathway activation, supporting vitamin C as a translatable nutritional strategy to combat reproductive aging.
dlvr.it
November 7, 2025 at 3:08 AM
Vitamin C conveys geroprotection on primate ovaries
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models
Brivanlou and colleagues used optogenetics to spatially control BMP4 expression in human stem cell models across different mechanical regimes. By combining these experiments with mathematical modeling, they dissected how biochemical signals and mechanical forces integrate to initiate symmetry breaking at the onset of gastrulation.
dlvr.it
November 7, 2025 at 12:37 AM
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models
Hypoxia promotes airway differentiation in the human lung epithelium
Hypoxia promotes airway differentiation in the human lung epithelium
Dong and colleagues uncover low oxygen-directed differentiation of human lung progenitors to airway rather than alveolar fate and show how the process is controlled by hypoxia-inducible factors. Hypoxia also converts differentiated alveolar cells into airway-like cells. Hypoxia is therefore both a developmental cue and a pathological factor in human lungs.
dlvr.it
November 6, 2025 at 10:15 PM
Hypoxia promotes airway differentiation in the human lung epithelium
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential
(Cell Stem Cell 29, 1669–1684.e1–e6; December 1, 2022)
dlvr.it
November 6, 2025 at 8:09 PM
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential
Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular degeneration: Low-dose clinical outcomes
Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular degeneration: Low-dose clinical outcomes
Retinal pigment epithelium (RPE) cell loss in dry age-related macular degeneration leads to progressive vision decline. Stern and others implanted adult RPE stem cell-derived RPE progeny at a 4-week progenitor stage of differentiation (RPESC-RPE-4W). First-in-human cohort 1 met primary safety endpoints, with greater visual improvement observed in worse-seeing eyes.
dlvr.it
November 6, 2025 at 5:00 PM
Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular degeneration: Low-dose clinical outcomes
Online Now! A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders #stemcells
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders
Wang and colleagues present a phenotypic brain organoid atlas for neurodevelopmental disorders, revealing disease-specific cellular and molecular alterations that illuminate NDD pathogenesis. Integrating patient brain organoids, imaging, and exome sequencing, this resource provides a powerful platform to advance research and therapeutic discovery.
dlvr.it
November 4, 2025 at 12:36 AM
Online Now! A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders #stemcells
Online Now! Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity #stemcells
Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
The tumor stroma contains heterogenous cell types with senescent phenotypes. Lee et al. characterize a cancer-associated fibroblast (CAF) subtype characterized by p16INK4a expression and myofibroblastic differentiation that drives tumor plasticity and progression. p16INK4a+ CAF is druggable and presents a therapeutic target for highly aggressive lung adenocarcinoma.
dlvr.it
November 3, 2025 at 8:09 PM
Online Now! Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity #stemcells
Online Now! Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids #stemcells
Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids
The nucleus basalis of Meynert (nbM) regulates cortical function and cognition. Liu and colleagues report a method for creating human nbM organoids (hnbMOs) containing cholinergic projection neurons that form functional connections with the cortex. This work provides a model to investigate nbM circuits and cholinergic dysfunction in neurological disorders.
dlvr.it
November 3, 2025 at 3:10 PM
Online Now! Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids #stemcells
Online Now! N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells #stemcells
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells
Zhu and colleagues reported that METTL3 inhibition in naive hESCs upregulated 8C-associated transcripts, including LTRs, and promoted chromatin opening. Reducing m6A on primate-specific L1PA mimicked this transcriptome transition, influencing LTR binding and protein preferences for L1-mediated chromatin recruitment, particularly suppressing EP300 binding to ERV1 and enhancing KAP1 binding to ERVL-MaLR.
dlvr.it
October 29, 2025 at 7:09 PM
Online Now! N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells #stemcells
Online Now! 3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy #stemcells
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy
Chen and colleagues present a 3D differentiation method for the efficient and robust generation of mDAP-enriched donor cells from hPSCs. They mapped the clonal lineages between donor cells and their derivatives within grafts following transplantation, which facilitates further refinement of the differentiation method and the elimination of off-target lineage cells.
dlvr.it
October 27, 2025 at 11:36 PM
Online Now! 3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy #stemcells
Online Now! Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling #stemcells
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate cardiac development and conduction and, under chronic inflammation, recapitulate atrial fibrillation features, offering a powerful model to study immune-cardiac interactions and arrhythmia mechanisms.
dlvr.it
October 27, 2025 at 7:09 PM
Online Now! Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling #stemcells
Online Now! EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming #stemcells
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming
Zeng et al. identify EZHIP as a critical epigenetic reprogramming factor in mouse early embryos, which promotes global erasure, intergenerational inheritance, and re-establishment of H3K27me3. They demonstrate that without EZHIP restriction, hyperactive PRC2 deposits promiscuous H3K27me3 across the genome, which paradoxically causes loss of H3K27me3-mediated imprinting memories and gene repression.
dlvr.it
October 20, 2025 at 7:10 PM
Online Now! EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming #stemcells
Less than 3 weeks before scientists and clinicians convene in Los Angeles, CA for @CellSymposia #CSStemCells2025. Check out the scientific program and register today: http://dlvr.it/TNkn4M
October 17, 2025 at 3:51 PM
Less than 3 weeks before scientists and clinicians convene in Los Angeles, CA for @CellSymposia #CSStemCells2025. Check out the scientific program and register today: http://dlvr.it/TNkn4M
Online Now! Vitamin C conveys geroprotection on primate ovaries #stemcells
Vitamin C conveys geroprotection on primate ovaries
Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles. These geroprotective effects are partially mediated through NRF2 pathway activation, supporting vitamin C as a translatable nutritional strategy to combat reproductive aging.
dlvr.it
October 14, 2025 at 7:09 PM
Online Now! Vitamin C conveys geroprotection on primate ovaries #stemcells