Cell Reports
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Genomic insights into karyotype evolution and adaptive mechanisms in Polygonaceae species
Genomic insights into karyotype evolution and adaptive mechanisms in Polygonaceae species
Liu et al. report chromosome-level genomes of 11 species across 10 Polygonaceae genera (including four previously published genomes), which encompass diverse habitats. Integrating genomic and transcriptomic analyses, this study provides insights into the evolutionary adaptation strategies of Polygonaceae to thrive in various habitats.
dlvr.it
November 23, 2025 at 8:50 PM
Genomic insights into karyotype evolution and adaptive mechanisms in Polygonaceae species
DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy
DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy
Li et al. reveal how the spike proteins of Getah virus, an arthropod-borne alphavirus, are modified by fatty acid attachment. They identify the acyltransferase DHHC11 as a key host enzyme required for efficient infection across multiple alphavirus species, presenting a promising broad-spectrum antiviral target for emerging alphavirus threats.
dlvr.it
November 23, 2025 at 3:38 PM
DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
Singh et al. show that TMZ treatment in glioblastoma induces ATR- and PNPT1-dependent degradation of miR-181d. Loss of miR-181d de-represses PNPT1, establishing a feedforward loop that amplifies TMZ-induced miR-181d degradation. This circuit enhances MGMT expression and cell-to-cell variability, highlighting a mechanism driving resistance to alkylating chemotherapy.
dlvr.it
November 23, 2025 at 1:36 PM
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
Endothelial IL-36 receptor activation promotes vascular stability to limit pathological microvessel permeability in the CNS
Endothelial IL-36 receptor activation promotes vascular stability to limit pathological microvessel permeability in the CNS
Only a small number of barrier-enhancing factors have been discovered to specifically increase barrier integrity, enhance vessel stability, and make vessels resistant to fluid leakage. Here, Fahey et al. present DEVDIL-36β as a cytokine promoter of vascular integrity in the CNS, with barrier-enhancing properties through upregulation of junctional components.
dlvr.it
November 23, 2025 at 12:23 AM
Endothelial IL-36 receptor activation promotes vascular stability to limit pathological microvessel permeability in the CNS
CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesia
CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesia
Miller et al. use fMRI to demonstrate that human hippocampal CA2/3 subfield damage results in retrograde autobiographical amnesia and destabilized frontal autobiographical mnemonic representations. Mnemonic stability in the right inferior frontal gyrus predicts retrograde episodic memory performance.
dlvr.it
November 22, 2025 at 8:50 PM
CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesia
Patient-derived organoids to study glycosylation dynamics during gastric disease
Patient-derived organoids to study glycosylation dynamics during gastric disease
Santos-Ferreira et al. established a gastric organoid biobank from normal, adjacent, and tumor tissues to assess glycosylation fidelity. Organoids recapitulate tissue-specific glycosylation, preserve tumor heterogeneity, and dynamically regulate Lewis antigen expression, thereby shaping H. pylori binding. This work establishes gastric organoids as robust ex vivo models of in vivo tissue glycosylation.
dlvr.it
November 22, 2025 at 3:39 PM
Patient-derived organoids to study glycosylation dynamics during gastric disease
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling
Zhan et al. show that blood vessels serve as a migratory scaffold directing retinal microglial precursor infiltration into the developing retina. Vascular Lamb1 signaling orchestrates this precise migration, indicating a key mechanism guiding retinal microglial colonization during development.
dlvr.it
November 22, 2025 at 1:36 PM
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling
Inducing ferroptosis to impede metastasis by inhibiting the calcium channel TRPC6
Inducing ferroptosis to impede metastasis by inhibiting the calcium channel TRPC6
Dimitrov et al. report that the calcium channel TRPC6 enables TNBC cells to evade ferroptosis by repressing c-Myc to sustain glutathione levels. This channel has a causal role in metastasis, and its targeted inhibition impedes metastasis by inducing ferroptosis.
dlvr.it
November 22, 2025 at 12:23 AM
Inducing ferroptosis to impede metastasis by inhibiting the calcium channel TRPC6
Diverse defense systems and prophages in human-associated Bifidobacterium species reveal coevolutionary “arms race” dynamics
Diverse defense systems and prophages in human-associated Bifidobacterium species reveal coevolutionary “arms race” dynamics
Despite bifidobacteria playing essential roles in human and infant health, large-scale studies of their interactions with phages are scarce. Docherty et al. uncover a diverse repertoire of antiviral defenses, including phage-specific CRISPR-Cas and prophage counter-defenses. The observed coevolutionary dynamics shape genomic diversity and may have potential biomedical and commercial relevance.
dlvr.it
November 21, 2025 at 8:50 PM
Diverse defense systems and prophages in human-associated Bifidobacterium species reveal coevolutionary “arms race” dynamics
ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation
ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation
Li et al. report that ID1 sustains STING activation and innate immunity by blocking PRMT5-STING binding, thereby preventing PRMT5-mediated methylation at Arg281 of STING. The PRMT5 inhibitor EPZ015666 enhances STING activation by suppressing PRMT5, providing a therapeutic candidate for antiviral treatment.
dlvr.it
November 21, 2025 at 3:38 PM
ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation
Mori and colleagues show that the integrated stress response (ISR) cascade triggered in the postsynaptic muscle of the Drosophila larval neuromuscular junction (NMJ) by acute amino acid restriction maintains baseline presynaptic release. This ATF4-independent, non-canonical ISR cascade enhances translation of Still life (Sif) and promotes neurotransmitter output at the NMJ.
dlvr.it
November 21, 2025 at 1:35 PM
A retrograde, non-canonical integrated stress response cascade maintains synaptic strength under amino acid deprivation
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis
How traumatic brain injury (TBI) mechanistically contributes to neurodegenerative disease remains poorly understood. Marco et al. find that therapeutic viral vector-based delivery of VEGFC recuperates meningeal lymphatic drainage deficits post-TBI and protects against severe development of tauopathy, neurodegeneration, and cognitive decline in the PS19 mouse model of tauopathy.
dlvr.it
November 21, 2025 at 12:23 AM
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis
Fat knows its limits: Creatine kinases keep adipocytes in check
Fat knows its limits: Creatine kinases keep adipocytes in check
The prevalence of obesity has led to significant interest in identifying the molecular mediators of adipose tissue expansion. In a recent issue of Cell Reports, Renzi and colleagues reveal a new mechanism by which creatine kinase B (CKB) regulates de novo lipogenesis in white adipocytes.
dlvr.it
November 20, 2025 at 8:51 PM
Fat knows its limits: Creatine kinases keep adipocytes in check
The pan-cancer mutational landscape of MLL3 and its impact on prognosis and immunochemotherapy
The pan-cancer mutational landscape of MLL3 and its impact on prognosis and immunochemotherapy
MLL3 is frequently mutated across cancers. Liu et al. reveal that these mutations are associated with enhanced immune infiltration, predicting improved survival and immunochemotherapy response in endometrial and colon cancers, while Mll3 ablation in mouse models confirms its role in promoting anti-tumor immunity.
dlvr.it
November 20, 2025 at 3:38 PM
The pan-cancer mutational landscape of MLL3 and its impact on prognosis and immunochemotherapy
Genetic mapping and predictive modeling of paralog synthetic lethality
Genetic mapping and predictive modeling of paralog synthetic lethality
Synthetic lethal paralogs have long been known, yet most paralog interactions are untested. Flister et al. report a screen of 36,648 known human paralog pairs. These data combined with a meta-analysis of 462 pairs across 49 cell models revealed insights into the molecular underpinnings of context-dependent synthetic lethality.
dlvr.it
November 20, 2025 at 1:36 PM
Genetic mapping and predictive modeling of paralog synthetic lethality
Together with our partners at Zhejiang University, Liangzhu Laboratory, we're thrilled to announce the Cell Symposium: Taking programmed cell death from mechanisms to interventions, taking place in Hangzhou, China, October 22–24, 2026
http://dlvr.it/TPMsG3
#CSCellDeath26
http://dlvr.it/TPMsG3
#CSCellDeath26
November 20, 2025 at 12:31 PM
Together with our partners at Zhejiang University, Liangzhu Laboratory, we're thrilled to announce the Cell Symposium: Taking programmed cell death from mechanisms to interventions, taking place in Hangzhou, China, October 22–24, 2026
http://dlvr.it/TPMsG3
#CSCellDeath26
http://dlvr.it/TPMsG3
#CSCellDeath26
Situating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping
Situating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping
(Cell Reports 44, 115207; January 28, 2025)
dlvr.it
November 20, 2025 at 12:23 AM
Situating the salience and parietal memory networks in the context of multiple parallel distributed networks using precision functional mapping
Nuclear-lamin-guided plastic positioning and folding of the human genome
Nuclear-lamin-guided plastic positioning and folding of the human genome
Wang et al. systematically depicted the lamins-guided 3D epigenome in human stem cells and demonstrated that lamins not only serve as key regulators of chromatin-NL tethering and large-scale genome organization but also are essential for the spatial positioning and clustering of nuclear speckle through direct interactions within the nuclear interior.
dlvr.it
November 19, 2025 at 8:50 PM
Nuclear-lamin-guided plastic positioning and folding of the human genome
Monocyte-derived cells promote transient insult-induced brain injury by enhancing CD8+ T cell response
Monocyte-derived cells promote transient insult-induced brain injury by enhancing CD8+ T cell response
Zuo et al. show monocyte-derived cells as key contributors to transient insult-induced brain injury. These cells infiltrate lesions, exhibit antigen-presenting features, and promote CD8+ T cell response, potentially through co-stimulatory signaling. Depleting them or blocking their interaction with CD8+ T cells alleviates cognitive impairment, suggesting a potential target for therapy.
dlvr.it
November 19, 2025 at 3:38 PM
Monocyte-derived cells promote transient insult-induced brain injury by enhancing CD8+ T cell response
REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner
REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner
Campelo et al. show that REM sleep induces region-specific changes in cortical excitability, with NMDARs playing a crucial role. Diazepam-induced sleep differs from natural sleep by disrupting normal inhibitory circuits, suggesting that hypnotic drugs may compromise sleep-dependent brain functions.
dlvr.it
November 19, 2025 at 1:36 PM
REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner
Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication
Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication
(Cell Reports 18, 3033–3042; March 28, 2017)
dlvr.it
November 19, 2025 at 12:23 AM
Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication
Creatine kinase B regulates glycolysis and de novo lipogenesis pathways to control lipid accumulation during adipogenesis
Creatine kinase B regulates glycolysis and de novo lipogenesis pathways to control lipid accumulation during adipogenesis
Renzi et al. identify creatine kinase B (CKB) as a metabolic sensor during white adipocyte differentiation. By modulating AKT, CKB fine-tunes insulin signaling and glycolysis to restrain ChREBP activation, thereby controlling de novo lipogenesis. This work links creatine metabolism to nutrient-responsive transcriptional regulation of lipid accumulation.
dlvr.it
November 18, 2025 at 8:51 PM
Creatine kinase B regulates glycolysis and de novo lipogenesis pathways to control lipid accumulation during adipogenesis
Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer
Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer
Li et al. reveal that a high-fat diet promotes prostate cancer progression and resistance to CDK4/6 inhibitors. By linking RB1 phosphorylation, ETS1 reactivation, and phosphatidylcholine metabolism, the findings highlight a diet-metabolism-transcription axis that underlies therapeutic resistance.
dlvr.it
November 18, 2025 at 3:39 PM
Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer
Molecular and functional asymmetry in Cckar-expressing vagal sensory neurons
Molecular and functional asymmetry in Cckar-expressing vagal sensory neurons
Welch et al. identify a molecularly distinct population of gut-innervating vagal sensory neurons that are enriched in the right nodose ganglion. These neurons, which co-express Cckar and Chrna3, give rise to right-side biased signaling by cholecystokinin 1 receptors and may contribute to lateralized transduction of interoceptive rewards.
dlvr.it
November 18, 2025 at 1:36 PM
Molecular and functional asymmetry in Cckar-expressing vagal sensory neurons
Fusaric acid detoxification mediates interspecies interactions for sustainable Fusarium wilt disease management
Fusaric acid detoxification mediates interspecies interactions for sustainable Fusarium wilt disease management
Cao et al. show that Trichoderma harzianum detoxifies fusaric acid into the non-toxic metabolite 10OH-FSA, thereby suppressing disease and fostering beneficial microbial networks. This work reveals toxin neutralization as an ecological strategy for sustainable control of soil-borne plant diseases.
dlvr.it
November 18, 2025 at 12:23 AM
Fusaric acid detoxification mediates interspecies interactions for sustainable Fusarium wilt disease management