This work highlights how interactions between MGEs can produce unique effects where both benefit from their nested existence. Furthermore, we have extended TnpB’s mechanism that sheds light on why TnpB is so successful.

So we did a similar experiment with conjugative plasmids and found that IS605 provides offensive and defensive benefits to conjugative plasmids, acting like a primitive anti-self defense mechanism to spread plasmids between cells.

But in the context of plasmids this results in a newly inserted IS605 to reprogram TnpB to target, and destroy, all IS- plasmids within the cell. With no competition only IS+ plasmids will replicate, biasing their inheritance.

😳😮

www.dhmo.org/facts.html

I had been elated to attend a scientific talk from a legend. It was fucking weird to see him objectifying these women. No mention of their scientific contributions, only their role as romantic interests. He even joked about how they knew not to work late nights in the lab because he might show up. 🤮

Yay Zam! Very happy to see your work recognized like this.

Are there good challengers yet?