ComplexPortal
@complexportal.bsky.social
The Complex Portal is an encyclopaedic resource of macromolecular complexes from a number of key model organisms.
http://www.ebi.ac.uk/complexportal
Also follow➡️@intact-ebi.bsky.social
http://www.ebi.ac.uk/complexportal
Also follow➡️@intact-ebi.bsky.social
Reposted by ComplexPortal
Reposted by ComplexPortal
Follow the link to uncover:
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
November 6, 2025 at 12:38 PM
Follow the link to uncover:
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
🧩 what the complex does in the cell
🔄 pathways it participates in (Reactome)
🧬 and curated disease links (EFO, MONDO, OMIM).
PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
🔬 Noticed the new look PDBe?
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
November 6, 2025 at 12:38 PM
🔬 Noticed the new look PDBe?
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal!
Example: PDB 6OOY → TNFA complex (CPX-8826).
Reposted by ComplexPortal
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
November 5, 2025 at 12:10 PM
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
Don’t just publish - be found! 🔍
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
October 19, 2025 at 1:25 PM
Don’t just publish - be found! 🔍
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
October 12, 2025 at 1:44 PM
🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
Reposted by ComplexPortal
See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
October 1, 2025 at 8:27 AM
Reposted by ComplexPortal
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
October 1, 2025 at 9:31 AM
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
Reposted by ComplexPortal
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
October 1, 2025 at 8:27 AM
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
October 1, 2025 at 8:27 AM
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
Reposted by ComplexPortal
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
September 22, 2025 at 10:31 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
Reposted by ComplexPortal
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
September 22, 2025 at 9:35 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
September 22, 2025 at 10:31 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
Reposted by ComplexPortal
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
September 22, 2025 at 8:59 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
Reposted by ComplexPortal
IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)
September 12, 2025 at 9:08 AM
IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)
Reposted by ComplexPortal
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
September 8, 2025 at 1:11 PM
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
Reposted by ComplexPortal
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
September 8, 2025 at 10:15 AM
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🧠 Ever wonder how your tongue detects umami or sweetness?
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
August 28, 2025 at 2:24 PM
🧠 Ever wonder how your tongue detects umami or sweetness?
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)
Complex Portal
EMBL-EBI
www.ebi.ac.uk
August 28, 2025 at 1:16 PM
Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)
🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
July 17, 2025 at 9:50 AM
🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins.
🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)
Intronic repeats play big roles evolution, gene regulation & disease. They're linked to disorders like Haemophilia & cancer. Cells keep them in check through RNAi-driven heterochromatin formation. See the S. pombe CLR4 complex (CPX-9241) & learn about its involvement in transcriptional silencing.
July 2, 2025 at 4:05 PM
Intronic repeats play big roles evolution, gene regulation & disease. They're linked to disorders like Haemophilia & cancer. Cells keep them in check through RNAi-driven heterochromatin formation. See the S. pombe CLR4 complex (CPX-9241) & learn about its involvement in transcriptional silencing.
Reposted by ComplexPortal
Do you use EMBL-EBI data resources? We would really appreciate your feedback!
Our Interim Director Jo McEntyre explains how you can help us demonstrate the value of our data resources: www.ebi.ac.uk/about/news/a...
Survey closes on 16 July: www.surveymonkey.com/r/QGFMBH8?ch...
Thank you!
Our Interim Director Jo McEntyre explains how you can help us demonstrate the value of our data resources: www.ebi.ac.uk/about/news/a...
Survey closes on 16 July: www.surveymonkey.com/r/QGFMBH8?ch...
Thank you!
User survey to understand the value of open data resources
EMBL-EBI user survey opens – please complete it before 16 July
www.ebi.ac.uk
June 30, 2025 at 10:42 AM
Do you use EMBL-EBI data resources? We would really appreciate your feedback!
Our Interim Director Jo McEntyre explains how you can help us demonstrate the value of our data resources: www.ebi.ac.uk/about/news/a...
Survey closes on 16 July: www.surveymonkey.com/r/QGFMBH8?ch...
Thank you!
Our Interim Director Jo McEntyre explains how you can help us demonstrate the value of our data resources: www.ebi.ac.uk/about/news/a...
Survey closes on 16 July: www.surveymonkey.com/r/QGFMBH8?ch...
Thank you!
Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
June 27, 2025 at 2:23 PM
Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC).
➡️ Register now:
tinyurl.com/bdy6wttv
Reposted by ComplexPortal
What do Nobel laureates, early-career researchers, and pioneering scientists have in common?
🧬 They all attend EMBL Events!
Want in? Whether you're into molecules, cells, or data – there's something for you!
🚀 Subscribe now and stay in the loop:
👉 http://eepurl.com/dv95w9
🧬 They all attend EMBL Events!
Want in? Whether you're into molecules, cells, or data – there's something for you!
🚀 Subscribe now and stay in the loop:
👉 http://eepurl.com/dv95w9
June 25, 2025 at 7:35 AM
What do Nobel laureates, early-career researchers, and pioneering scientists have in common?
🧬 They all attend EMBL Events!
Want in? Whether you're into molecules, cells, or data – there's something for you!
🚀 Subscribe now and stay in the loop:
👉 http://eepurl.com/dv95w9
🧬 They all attend EMBL Events!
Want in? Whether you're into molecules, cells, or data – there's something for you!
🚀 Subscribe now and stay in the loop:
👉 http://eepurl.com/dv95w9
This month features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search the CP using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #MolBiol, #ubiquitin
June 3, 2025 at 9:28 AM
This month features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search the CP using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #MolBiol, #ubiquitin