Lab turns two today ❤️ so happy

I am excited to share our first Pt replica EM images. It took us a little while, but now we have establish the unroofing, drying and Pt coating workflow 🎉 Great work by our postdoc Luis Wong Dilworth! The image below shows the cytosolic membrane leaflet of a fibroblast 👇

Hello new followers 🖖 I like looking at the plasma membrane by high res microscopy. Here, you see a platinum replica EM of a fibroblast plasma membrane with clathrin dome (in the center) and caveolae (small invaginations on the side)

Lipid droplets for everyone! #fluorescencefriday

Here are some more images of clathrin

Caveolae‘s big brother : clathrin! Here we can see beautiful clathrin lattices deforming the plasma membrane lipids to a dome. Some of them will end up as spheres that can be internalized into the cell (this process is called endocytosis)

Caveolae are small plasma membrane invaginations (50-100 nm) found in many cell types. Here you can see the typical shape and coat structure of caveolae - in particular the cavin protein stripe coat is visible. (We are looking from the inside of a cell to the plasma membrane)

Hello Blue sky, I like caveolae and lipid droplets