Chris Kyriazis
@ckyriazis.bsky.social
Postdoc at the San Diego Zoo Wildlife Alliance interested in population genetics & conservation genomics https://chriskyriazis.weebly.com/
very cool! congrats Ethan
November 21, 2025 at 8:24 PM
very cool! congrats Ethan
We think this simple ID_risk statistic could have a lot of practical utility in providing a simple and reliable means for identifying populations where ID is likely to be strong, which doesnt suffer from many of the same issues that genetic load proxies do (e.g., doi.org/10.1101/2025...) n/n
Genetic load proxies do not predict fitness better than inbreeding does in a wild population
A key goal in conservation is managing endangered populations in order to maximise individual and population fitness. Genetic management that reduces inbreeding and increases genetic diversity has bee...
www.biorxiv.org
August 4, 2025 at 5:10 PM
We think this simple ID_risk statistic could have a lot of practical utility in providing a simple and reliable means for identifying populations where ID is likely to be strong, which doesnt suffer from many of the same issues that genetic load proxies do (e.g., doi.org/10.1101/2025...) n/n
We set out to explore the empirical behavior of the ID_risk statistic, and what we found I think is pretty cool! Specifically, it’s interesting to see that IR wolves and FL panthers have by far the highest ID_risk, which makes sense given the high severity of inbreeding depression in these pops 8/n
August 4, 2025 at 5:10 PM
We set out to explore the empirical behavior of the ID_risk statistic, and what we found I think is pretty cool! Specifically, it’s interesting to see that IR wolves and FL panthers have by far the highest ID_risk, which makes sense given the high severity of inbreeding depression in these pops 8/n
Our idea was perhaps we can devise a composite statistic for predicting risk of inbreeding depression in a population (ID_risk) simply by multiplying FROH and non-ROH het. As either of these quantities increase, so too should the threat of ID, so maybe there’s value in considering them together. 7/n
August 4, 2025 at 5:10 PM
Our idea was perhaps we can devise a composite statistic for predicting risk of inbreeding depression in a population (ID_risk) simply by multiplying FROH and non-ROH het. As either of these quantities increase, so too should the threat of ID, so maybe there’s value in considering them together. 7/n
Another component that seemed relevant is the impact of heterozygosity in non-ROH regions, which should correlate with the inbreeding/masked load in a species. This is because more genome-wide hets = more recessive deleterious mutations as hets that can lead to inbreeding depression 6/n
August 4, 2025 at 5:10 PM
Another component that seemed relevant is the impact of heterozygosity in non-ROH regions, which should correlate with the inbreeding/masked load in a species. This is because more genome-wide hets = more recessive deleterious mutations as hets that can lead to inbreeding depression 6/n
This got me thinking…are we now at the point where it’s fair to assume a priori that, if long ROH are abundant in a population, it is likely suffering from inbreeding depression? Here, we argue that may now be the case. 5/n www.sciencedirect.com/science/arti...
Long runs of homozygosity are reliable genomic markers of inbreeding depression
A long-standing goal in ecological, evolutionary, and conservation genetics is to identify genomic correlates of fitness and inbreeding depression. Ov…
www.sciencedirect.com
August 4, 2025 at 5:10 PM
This got me thinking…are we now at the point where it’s fair to assume a priori that, if long ROH are abundant in a population, it is likely suffering from inbreeding depression? Here, we argue that may now be the case. 5/n www.sciencedirect.com/science/arti...
Paper after paper in species including wolves, dogs, humans, killer whales, etc all seem to tell a similar story. With this in mind, it was no surprise when we found a strong correlation between long ROH and survival/reproduction in ‘akikiki here: www.cell.com/current-biol...
4/n
4/n
August 4, 2025 at 5:10 PM
Paper after paper in species including wolves, dogs, humans, killer whales, etc all seem to tell a similar story. With this in mind, it was no surprise when we found a strong correlation between long ROH and survival/reproduction in ‘akikiki here: www.cell.com/current-biol...
4/n
4/n
Maybe my favorite is this paper on Soay sheep where they quantify these effects using SNP and mortality data for ~6000 sheep. For instance, they show that a 1% increase in long ROH reduces first year survival by 12.4%, whereas short ROH have no discernible impact. 3/n doi.org/10.1002/evl3...
August 4, 2025 at 5:10 PM
Maybe my favorite is this paper on Soay sheep where they quantify these effects using SNP and mortality data for ~6000 sheep. For instance, they show that a 1% increase in long ROH reduces first year survival by 12.4%, whereas short ROH have no discernible impact. 3/n doi.org/10.1002/evl3...
The starting point for this paper is the growing body of research showing the large influence of long ROH on fitness and relatively minimal effects of short ROH. This literature is super exciting both because all these papers seem to tell the same story and agree with what we expect from theory! 2/n
August 4, 2025 at 5:10 PM
The starting point for this paper is the growing body of research showing the large influence of long ROH on fitness and relatively minimal effects of short ROH. This literature is super exciting both because all these papers seem to tell the same story and agree with what we expect from theory! 2/n