Christophe Zimmer
@chzimmer.bsky.social
Computational biophysicist @ University of Würzburg (Germany) and @ Institut Pasteur (France). Machine Biophotonics Lab (Würzburg). Imaging and Modeling Unit (Paris). Translational imaging, deep learning for biology, drug discovery.
Great collaboration with the lab of Edouard Bertrand, with important contributions from Benoît Lelandais, Marie-Cécile Robert, Michael Szalay, and Jean-Yves Tinevez. Thanks a lot to all.
www.nature.com/articles/s41...
(4/4)
www.nature.com/articles/s41...
(4/4)
Uniform dynamics of cohesin-mediated loop extrusion in living human cells - Nature Genetics
Live-cell fluorescence microscopy and polymer simulations in human HCT116 cells show similar cohesin density, residence times and extrusion speed across multiple genomic regions.
www.nature.com
November 23, 2025 at 4:35 PM
Great collaboration with the lab of Edouard Bertrand, with important contributions from Benoît Lelandais, Marie-Cécile Robert, Michael Szalay, and Jean-Yves Tinevez. Thanks a lot to all.
www.nature.com/articles/s41...
(4/4)
www.nature.com/articles/s41...
(4/4)
Our data are consistent with constant binding rate, lifetime and extrusion speed of cohesin across different regions. This argues for a model where TAD dynamics is mainly governed by CTCF sites and opens the door to predictive simulations of DNA folding across the entire human genome. (3/4)
November 23, 2025 at 4:35 PM
Our data are consistent with constant binding rate, lifetime and extrusion speed of cohesin across different regions. This argues for a model where TAD dynamics is mainly governed by CTCF sites and opens the door to predictive simulations of DNA folding across the entire human genome. (3/4)
Tracking the 3D motion of loop anchors in multiple genomic regions, we confirm that TADs are highly dynamic. Our analyses indicate that TADs constantly fold into multiple extruding loops that bring anchors briefly together ~1x per hour, effectively shrinking their genomic distance by ~0.1 kb/s.(2/4)
November 23, 2025 at 4:35 PM
Tracking the 3D motion of loop anchors in multiple genomic regions, we confirm that TADs are highly dynamic. Our analyses indicate that TADs constantly fold into multiple extruding loops that bring anchors briefly together ~1x per hour, effectively shrinking their genomic distance by ~0.1 kb/s.(2/4)