Chrystal Paulos
@chrystalpaulos.bsky.social
Tumor immunologist, Director of Translational Medicine, Cutaneous Malignancies. Assoc. Professor of Surgery/Microbiology & Immunology at Emory. Fitness is fun @PaulosLab
6/ 🔬IL-21 production by Th17 cells is essential. Block the IL-21 receptor and the B cell response crashes (Fig 7).
Reduced germinal centers. Less plasma cells. No sustained immunity. IL-21 is the handshake between these two arms.
Reduced germinal centers. Less plasma cells. No sustained immunity. IL-21 is the handshake between these two arms.
July 25, 2025 at 3:02 PM
6/ 🔬IL-21 production by Th17 cells is essential. Block the IL-21 receptor and the B cell response crashes (Fig 7).
Reduced germinal centers. Less plasma cells. No sustained immunity. IL-21 is the handshake between these two arms.
Reduced germinal centers. Less plasma cells. No sustained immunity. IL-21 is the handshake between these two arms.
5/ 🧠Here’s the kicker: If we transfer serum from cured mice into naive mice, they resist metastatic challenge. Passive transfer of protection. See the lungs in Fig 8F + quant in 8G. The antibodies *work*.
July 25, 2025 at 2:59 PM
5/ 🧠Here’s the kicker: If we transfer serum from cured mice into naive mice, they resist metastatic challenge. Passive transfer of protection. See the lungs in Fig 8F + quant in 8G. The antibodies *work*.
4/ 🧪Mice cured with Th17 therapy have tons of class-switched, tumor-binding antibodies in serum (IgG1, IgG2a, IgG2b). Shown in Fig 8A-C. Not just any antibody — it’s tumor-specific and persistent.
July 25, 2025 at 2:58 PM
4/ 🧪Mice cured with Th17 therapy have tons of class-switched, tumor-binding antibodies in serum (IgG1, IgG2a, IgG2b). Shown in Fig 8A-C. Not just any antibody — it’s tumor-specific and persistent.
2/ 🐭Want to keep tumors away for good?
Check out this weeks @cp-cancercell.bsky.social
You’ll need both T cells *and* B cells.
Th17 therapy fails in mice genetically deficient in B cells or in mice antibody depleted of B cells.
Bottom line:No host T/B cells, no cure!
See survival curves (Fig 3).
Check out this weeks @cp-cancercell.bsky.social
You’ll need both T cells *and* B cells.
Th17 therapy fails in mice genetically deficient in B cells or in mice antibody depleted of B cells.
Bottom line:No host T/B cells, no cure!
See survival curves (Fig 3).
July 25, 2025 at 2:55 PM
2/ 🐭Want to keep tumors away for good?
Check out this weeks @cp-cancercell.bsky.social
You’ll need both T cells *and* B cells.
Th17 therapy fails in mice genetically deficient in B cells or in mice antibody depleted of B cells.
Bottom line:No host T/B cells, no cure!
See survival curves (Fig 3).
Check out this weeks @cp-cancercell.bsky.social
You’ll need both T cells *and* B cells.
Th17 therapy fails in mice genetically deficient in B cells or in mice antibody depleted of B cells.
Bottom line:No host T/B cells, no cure!
See survival curves (Fig 3).
Amazing talk by Dr. Ayana Ruffin @winship on the importance of CD2 in adoptive immunotherapy of cancer. It’s a T:B thing. #2025SIS on the UVA campus.
June 6, 2025 at 7:21 PM
Amazing talk by Dr. Ayana Ruffin @winship on the importance of CD2 in adoptive immunotherapy of cancer. It’s a T:B thing. #2025SIS on the UVA campus.
Excited to present at the first Breast Center Translational Research Seminar Series @winshipcancer.emory.edu Thank Dr. Shipra Gandhi for the invite.
May 13, 2025 at 1:19 AM
Excited to present at the first Breast Center Translational Research Seminar Series @winshipcancer.emory.edu Thank Dr. Shipra Gandhi for the invite.
Excited to present our labs work on novel T cell therapies @clevelandclinic.bsky.social virtually @winshipatemory.bsky.social Thank you for the invite #LilyWang!
March 27, 2025 at 12:09 PM
Excited to present our labs work on novel T cell therapies @clevelandclinic.bsky.social virtually @winshipatemory.bsky.social Thank you for the invite #LilyWang!
💥Cheers to Megen Wittling @megen-w.bsky.social @winshipatemory.bsky.social for presenting exciting work on the distinct trafficking & activation patterns of adoptively transferred CD8 T cells that recognize non-mutated va mutated tumors.
March 27, 2025 at 1:42 AM
💥Cheers to Megen Wittling @megen-w.bsky.social @winshipatemory.bsky.social for presenting exciting work on the distinct trafficking & activation patterns of adoptively transferred CD8 T cells that recognize non-mutated va mutated tumors.
Going to talk about antitumorT cell prowess at KUMC today. Thanks to Dr. Kalyani Pyaram for inviting me to visit and talk about our labs work @winshipatemory.bsky.social
March 26, 2025 at 12:34 PM
Going to talk about antitumorT cell prowess at KUMC today. Thanks to Dr. Kalyani Pyaram for inviting me to visit and talk about our labs work @winshipatemory.bsky.social
Delighted to present at the MD Anderson annual retreat this year in Galveston Texas.
March 21, 2025 at 4:33 PM
Delighted to present at the MD Anderson annual retreat this year in Galveston Texas.
We survived the Spartan Trial Run!
March 17, 2025 at 1:10 AM
We survived the Spartan Trial Run!
Congrats to our talented grad student Megen Wittling for being award this NCI F30 grant for her work in adoptive immunotherapy today! @megen-w.bsky.social @winshipatemory.bsky.social @sitcancer.bsky.social #EmoryMSTP
February 19, 2025 at 2:31 PM
Congrats to our talented grad student Megen Wittling for being award this NCI F30 grant for her work in adoptive immunotherapy today! @megen-w.bsky.social @winshipatemory.bsky.social @sitcancer.bsky.social #EmoryMSTP
Excellent talk by Dr. Zach Buchwald @zach-buchwald.bsky.social from @winshipatemory.bsky.social on immunotherapy in special patient populations. Talks about his amazing work on brain meta and circadian rhythm in immunity!! #CIWS2025 @sitcancer.bsky.social
February 13, 2025 at 8:58 PM
Excellent talk by Dr. Zach Buchwald @zach-buchwald.bsky.social from @winshipatemory.bsky.social on immunotherapy in special patient populations. Talks about his amazing work on brain meta and circadian rhythm in immunity!! #CIWS2025 @sitcancer.bsky.social
Great talk by Dr. Gregory Lesinski @lesinskilab.bsky.social @winshipatemory.bsky.social on how to get predictive biomarkers in every clinical trial @sitcancer.bsky.social #CIWS2025
February 13, 2025 at 6:22 PM
Great talk by Dr. Gregory Lesinski @lesinskilab.bsky.social @winshipatemory.bsky.social on how to get predictive biomarkers in every clinical trial @sitcancer.bsky.social #CIWS2025
Dr. @lesinskilab.bsky.social talks about his own teams experience of translating preclinical work into a clinical trial in PDAC patients by co-blocking PD-1 and IL-6 in a recently completed clinical trial. @sitcancer @WinshipAtEmory
February 12, 2025 at 8:07 PM
Dr. @lesinskilab.bsky.social talks about his own teams experience of translating preclinical work into a clinical trial in PDAC patients by co-blocking PD-1 and IL-6 in a recently completed clinical trial. @sitcancer @WinshipAtEmory
💥 Dr. Greg Lesinski @lesinskilab.bsky.social @sitcancer.bsky.social gives an outstanding talk on harnessing combination immunotherapies in preclinical models to guide new clinical trials for patients. #CIWS2025 @sitcancer.bsky.social 💥
February 12, 2025 at 8:04 PM
💥 Dr. Greg Lesinski @lesinskilab.bsky.social @sitcancer.bsky.social gives an outstanding talk on harnessing combination immunotherapies in preclinical models to guide new clinical trials for patients. #CIWS2025 @sitcancer.bsky.social 💥
Dr. Yina Huang brings the house down with her AMAZING talk on harnessing synthetic biology to augment next generation cell therapy for cancer patients at Winter School @sitcancer.bsky.social 💥
February 12, 2025 at 7:36 PM
Dr. Yina Huang brings the house down with her AMAZING talk on harnessing synthetic biology to augment next generation cell therapy for cancer patients at Winter School @sitcancer.bsky.social 💥
B cell guru and talented cancer immunotherapist Dr. Tullia Bruno at UPitt delivers an inspiring talk at Winter School today in Austin! 💥 @sitcancer.bsky.social
February 12, 2025 at 6:01 PM
B cell guru and talented cancer immunotherapist Dr. Tullia Bruno at UPitt delivers an inspiring talk at Winter School today in Austin! 💥 @sitcancer.bsky.social
There is more to do. There is more people to help with cancer research and immunotherapy clinical trials.
February 11, 2025 at 10:55 PM
There is more to do. There is more people to help with cancer research and immunotherapy clinical trials.
Dr. Sumit Subudhi talks about a patient who picked this new therapy called anti-CTLA4 therapy over going to hospice. He was cured of melanoma! @sitcancer.bsky.social m #CIWS2025 Winter school. Cancer research advances medicine and gives more days to life!!!
February 11, 2025 at 10:31 PM
Dr. Sumit Subudhi talks about a patient who picked this new therapy called anti-CTLA4 therapy over going to hospice. He was cured of melanoma! @sitcancer.bsky.social m #CIWS2025 Winter school. Cancer research advances medicine and gives more days to life!!!
Excellent talk by trailblazer Dr. Dan Powell @pennmedicine.bsky.social on adoptive immunotherapy and CAR T cells!@l @sitcancer.bsky.social #CIWS2025 Winter school in Austin.
February 11, 2025 at 9:32 PM
Excellent talk by trailblazer Dr. Dan Powell @pennmedicine.bsky.social on adoptive immunotherapy and CAR T cells!@l @sitcancer.bsky.social #CIWS2025 Winter school in Austin.
Wonder virtual talk by the one and only Dr Greg Delgoffe @delgoffelab.bsky.social on the immunosuppression in the tumor we must understand and battle to make a difference in our patients! #CIWS2026 @sitcancer.bsky.social
February 11, 2025 at 7:48 PM
Wonder virtual talk by the one and only Dr Greg Delgoffe @delgoffelab.bsky.social on the immunosuppression in the tumor we must understand and battle to make a difference in our patients! #CIWS2026 @sitcancer.bsky.social
Great talks by Drs. Kristin Anderson @immunegirl.bsky.social and Vic Engelhard from UVA at #CIWS2025 in Austin Tx @sitcancer.bsky.social on adaptive immunity and the tumor microenvironment.
February 11, 2025 at 7:22 PM
Great talks by Drs. Kristin Anderson @immunegirl.bsky.social and Vic Engelhard from UVA at #CIWS2025 in Austin Tx @sitcancer.bsky.social on adaptive immunity and the tumor microenvironment.
The fab Dr. Yana Najjar kicks off cancer immunotherapy winter school #CIWS2025 to talk about the history of the field! Elegant and wonderful speaker. @upittpress.bsky.social
February 11, 2025 at 2:08 PM
The fab Dr. Yana Najjar kicks off cancer immunotherapy winter school #CIWS2025 to talk about the history of the field! Elegant and wonderful speaker. @upittpress.bsky.social
Inspiring talk by Dr. Gregory Lesinski @lesinskilab.bsky.social on the wins and challenges of augmenting immunotherapy against cholangiocarcinoma @winshipatemory.bsky.social @sitcancer.bsky.social @cholangiocarcinoma.bsky.social
January 28, 2025 at 5:31 PM
Inspiring talk by Dr. Gregory Lesinski @lesinskilab.bsky.social on the wins and challenges of augmenting immunotherapy against cholangiocarcinoma @winshipatemory.bsky.social @sitcancer.bsky.social @cholangiocarcinoma.bsky.social