Charles Bayly-Jones
@charlesbj.bsky.social
Investigating protein nanomachines and their dynamics.
ARC DECRA Fellow at Monash University 🇦🇺.
Structural biologist. Author of WIGGLE. He/Him. 🏳️🌈
ARC DECRA Fellow at Monash University 🇦🇺.
Structural biologist. Author of WIGGLE. He/Him. 🏳️🌈
Earlier this year, I was incredibly honoured to receive the Premier’s Award for Health and Medical Research in the Basic Science category.
This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉
Photography and video: @vicgovau.bsky.social
www.youtube.com/watch?v=9_Ht...
This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉
Photography and video: @vicgovau.bsky.social
www.youtube.com/watch?v=9_Ht...
August 5, 2025 at 9:02 AM
Earlier this year, I was incredibly honoured to receive the Premier’s Award for Health and Medical Research in the Basic Science category.
This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉
Photography and video: @vicgovau.bsky.social
www.youtube.com/watch?v=9_Ht...
This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉
Photography and video: @vicgovau.bsky.social
www.youtube.com/watch?v=9_Ht...
Teeny tiny by day, bigly by night...
March 13, 2025 at 9:34 AM
Teeny tiny by day, bigly by night...
Saved a bee. 😎 That's the post.
March 12, 2025 at 9:12 PM
Saved a bee. 😎 That's the post.
Hot days (and grid atlases) are for a cold knock off beer... 🍻
February 26, 2025 at 6:03 AM
Hot days (and grid atlases) are for a cold knock off beer... 🍻
I've decided to start posting more mundane stuff to try and dilute some of the doom scrolling. Enjoying a bruschetta snack, nice view, and cucumber and yuzu G&T. Cheers.
February 24, 2025 at 8:59 AM
I've decided to start posting more mundane stuff to try and dilute some of the doom scrolling. Enjoying a bruschetta snack, nice view, and cucumber and yuzu G&T. Cheers.
Bier, Brot, und Wurst. 😍 Prost! Happy holidays.
December 31, 2024 at 1:21 AM
Bier, Brot, und Wurst. 😍 Prost! Happy holidays.
I told myself that I needed a large enough monitor to look at side chains within the whole complex... I might still need to get something bigger. 😅
December 7, 2024 at 3:41 AM
I told myself that I needed a large enough monitor to look at side chains within the whole complex... I might still need to get something bigger. 😅
The PDBs for our TSC structure are now available!
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
December 7, 2024 at 3:33 AM
The PDBs for our TSC structure are now available!
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
Finally TSC is extraordinarily flexible and is a massively difficult structural biology target. We had to use all the tricks we know to get this one... Parts of TSC can move by up to 10 nm!!!
November 20, 2024 at 9:48 PM
Finally TSC is extraordinarily flexible and is a massively difficult structural biology target. We had to use all the tricks we know to get this one... Parts of TSC can move by up to 10 nm!!!
Importantly, we discover that TSC recognises mono-phosphorylated phosphatidylinositols. These are known to regulate the mTORC1 pathway as signalling cues for growth.
November 20, 2024 at 9:48 PM
Importantly, we discover that TSC recognises mono-phosphorylated phosphatidylinositols. These are known to regulate the mTORC1 pathway as signalling cues for growth.
Our structure also highlights mutational hotspots, revealing new ways in which TSC mutations can drive disease or dysregulation of this pathway.
November 20, 2024 at 9:48 PM
Our structure also highlights mutational hotspots, revealing new ways in which TSC mutations can drive disease or dysregulation of this pathway.
We propose a docking mechanism that we expect is involved in TSC recruitment to the lysosomal membrane.
November 20, 2024 at 9:48 PM
We propose a docking mechanism that we expect is involved in TSC recruitment to the lysosomal membrane.
TSC is conserved back to yeast and is the major regulator of the mTORC1 pathway. We combined protein crystallography, cryo-electron microscopy, cross-linking mass spectrometry, and bioinformatic analysis to obtain the most complete picture of TSC to date.
November 20, 2024 at 9:48 PM
TSC is conserved back to yeast and is the major regulator of the mTORC1 pathway. We combined protein crystallography, cryo-electron microscopy, cross-linking mass spectrometry, and bioinformatic analysis to obtain the most complete picture of TSC to date.
🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances.
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
November 20, 2024 at 9:48 PM
🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances.
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
Just finished running 10km for the Melbourne #NF1 #colourrun, raising money for neurofibromatosis. www.ctf.org.au/donate
November 17, 2024 at 12:10 AM
Just finished running 10km for the Melbourne #NF1 #colourrun, raising money for neurofibromatosis. www.ctf.org.au/donate
Surreal to have our research highlighted by The Age! Piece by @angus_dalton
November 16, 2024 at 8:51 AM
Surreal to have our research highlighted by The Age! Piece by @angus_dalton
What a great couple of days in Brisbane, jam-packed with quality local Oz science and amazing keynotes from O/S colleagues @bronwynalucas, @KovtunOleksiy, and @SjorsScheres, plus many excellent ECR and PhD talks. Top notch! Thanks @AriottiNick, chairs, and organisers. #cryoz23
November 16, 2024 at 9:14 AM
What a great couple of days in Brisbane, jam-packed with quality local Oz science and amazing keynotes from O/S colleagues @bronwynalucas, @KovtunOleksiy, and @SjorsScheres, plus many excellent ECR and PhD talks. Top notch! Thanks @AriottiNick, chairs, and organisers. #cryoz23
Interesting new study on P-Rex1 from @tesmer_john & @Jen_Cash_11 groups. A great exemplar of how HDX can be a powerful tool in the integrative structural biology arsenal. Quite a bit of great biochemsitry as well. Well done.
https://www.biorxiv.org/content/10.1101/2023.09.15.557836v1
https://www.biorxiv.org/content/10.1101/2023.09.15.557836v1
November 16, 2024 at 9:38 AM
Interesting new study on P-Rex1 from @tesmer_john & @Jen_Cash_11 groups. A great exemplar of how HDX can be a powerful tool in the integrative structural biology arsenal. Quite a bit of great biochemsitry as well. Well done.
https://www.biorxiv.org/content/10.1101/2023.09.15.557836v1
https://www.biorxiv.org/content/10.1101/2023.09.15.557836v1
Absolutely amazing talk on high speed and high resolution #AFM from Simon @ScheuringLab #lorneproteins. Always a pleasure to see.
November 16, 2024 at 10:01 AM
Absolutely amazing talk on high speed and high resolution #AFM from Simon @ScheuringLab #lorneproteins. Always a pleasure to see.
@BradleySpicer presenting his beautiful structures of insecticidal nano pores 😍
November 16, 2024 at 10:10 AM
@BradleySpicer presenting his beautiful structures of insecticidal nano pores 😍
@LuptonCJ presenting our @NatureSMB work on neurofibromin at #lorneproteins. An engaging and entertaining lightning session. Australian EMCRs are killing it 😎
November 16, 2024 at 10:10 AM
@LuptonCJ presenting our @NatureSMB work on neurofibromin at #lorneproteins. An engaging and entertaining lightning session. Australian EMCRs are killing it 😎
November 16, 2024 at 10:26 AM
@LuptonCJ was too excited to take a fancy picture... 😅
November 16, 2024 at 10:42 AM
@LuptonCJ was too excited to take a fancy picture... 😅