Cascales Lab
@cascaleslab.bsky.social
How to specifically select a protein from one side of the membrane and to transport it on the other side ? That's what we love to understand. #T6SS #T9SS
Location: CNRS - Aix-Marseille Université, France
https://www.cascaleslab.fr
Location: CNRS - Aix-Marseille Université, France
https://www.cascaleslab.fr
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae
Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...
www.nature.com
November 15, 2025 at 3:55 PM
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Applications closing tonight (midnight French time) !!!
Still a few hours to apply !!
Still a few hours to apply !!
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 30, 2025 at 1:17 PM
Applications closing tonight (midnight French time) !!!
Still a few hours to apply !!
Still a few hours to apply !!
Reposted by Cascales Lab
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Cascales Lab
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com
PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com
www.findaphd.com
October 22, 2025 at 8:29 AM
PhD project available in my lab. Email me with CV if interested
www.findaphd.com/phds/project...
#microsky #bioimaging
www.findaphd.com/phds/project...
#microsky #bioimaging
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Cascales Lab
Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!
October 4, 2025 at 7:55 AM
Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!
Reposted by Cascales Lab
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...
doi.org
September 29, 2025 at 5:51 AM
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems !
Stay tuned !!
Stay tuned !!
September 28, 2025 at 9:25 AM
We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems !
Stay tuned !!
Stay tuned !!
Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
September 28, 2025 at 9:24 AM
Open position !!
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Either at the Engineer or post-doctoral level, to work on filamentous phages. Collaboration between Laetitia Houot's group and Thierry Doan @thicoz.bsky.social.
To apply at the E level:
emploi.cnrs.fr/Offres/CDD/U...
To apply at the post-doc level:
emploi.cnrs.fr/Offres/CDD/U...
Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins
Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition
and host interactions by delivering diverse cytotoxic domains through specialized
secretion systems. Here, we ...
www.jbc.org
September 28, 2025 at 9:20 AM
Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social
www.jbc.org/article/S002...
We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested:
emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Ingénieur d'Etude en Microbiologie (H/F)
emploi.cnrs.fr
July 8, 2025 at 2:55 PM
We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested:
emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr/Offres/CDD/U...
Le LISM (lism.imm.cnrs.fr) propose une mobilité en NOEMI pour travailler sur des assemblages de l'enveloppe bactérienne. Profil microbiologie, biologie moléculaire, avec une envie de faire de la biochimie, de la microscopie ou de la biologie cellulaire ! Rejoignez une unité dynamique !!
Welcome - LISM
The research topics of the LISM today remain centered on biological membranes and in particular membranes of Gram-negative bacteria. Since […]
lism.imm.cnrs.fr
May 3, 2025 at 5:30 PM
Le LISM (lism.imm.cnrs.fr) propose une mobilité en NOEMI pour travailler sur des assemblages de l'enveloppe bactérienne. Profil microbiologie, biologie moléculaire, avec une envie de faire de la biochimie, de la microscopie ou de la biologie cellulaire ! Rejoignez une unité dynamique !!
Reposted by Cascales Lab
Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
April 28, 2025 at 4:41 PM
Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For those interested on the bacterial envelope and on secretion system: a 2-day symposium in Marseille ! Second edition of the Secretion Days !
👉Don’t forget👈
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 15 via the following link:
🔗 docs.google.com/forms/d/e/1F...
📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊
🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social
🆓 Free, spot are limited !
📥 Registration is open until May 15 via the following link:
🔗 docs.google.com/forms/d/e/1F...
Journées Sécrétion 2025
Contact: [email protected]
docs.google.com
April 28, 2025 at 1:54 PM
For those interested on the bacterial envelope and on secretion system: a 2-day symposium in Marseille ! Second edition of the Secretion Days !
You are a young researcher working on the bacterial cell envelope ? Don't miss this opportunity !!
The Journées Sécrétion are back!
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
2nd and 3rd October in Marseille
Keynote lecture by: @archaellum.bsky.social
Registration is open until May 15: forms.gle/2qxHntTktoxw...
Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
March 18, 2025 at 12:25 PM
You are a young researcher working on the bacterial cell envelope ? Don't miss this opportunity !!
Great talk on RNA modifications in bacteria by Zeynep Baharoglu @zeynepbaharoglu.bsky.social at the weekly IMM seminar today !
March 7, 2025 at 11:20 AM
Great talk on RNA modifications in bacteria by Zeynep Baharoglu @zeynepbaharoglu.bsky.social at the weekly IMM seminar today !
Reposted by Cascales Lab
Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...
A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio
This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identifying the proteins involved in the formation of ...
journals.asm.org
February 25, 2025 at 6:20 PM
Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...
We have an open PhD position to work on bacterial secretion systems. Please RT, write us or apply through the CNRS job portal:
t.co/HxX23Od1oa
https://emploi.cnrs.fr/Offres/Doctorant/UMR7255-ERICAS-004/Default.aspx?lang=EN
t.co
January 18, 2025 at 11:56 AM
We have an open PhD position to work on bacterial secretion systems. Please RT, write us or apply through the CNRS job portal:
t.co/HxX23Od1oa
Happy to start a new social life on BlueSky !
Love from Marseille !
Love from Marseille !
January 18, 2025 at 11:53 AM
Happy to start a new social life on BlueSky !
Love from Marseille !
Love from Marseille !