Marie Carlén
@carlenlab.bsky.social
Systems neuroscientist at Karolinska Institutet studying the prefrontal cortex
Reposted by Marie Carlén
Happy birthday to us! 🥳
In 2003, we launched with just four employees in a small, rented laboratory working together towards a big goal - map the entire mammalian brain in a way the world had never seen.
🧠📈 #OpenScienceWeek
In 2003, we launched with just four employees in a small, rented laboratory working together towards a big goal - map the entire mammalian brain in a way the world had never seen.
🧠📈 #OpenScienceWeek
September 16, 2025 at 9:03 PM
Happy birthday to us! 🥳
In 2003, we launched with just four employees in a small, rented laboratory working together towards a big goal - map the entire mammalian brain in a way the world had never seen.
🧠📈 #OpenScienceWeek
In 2003, we launched with just four employees in a small, rented laboratory working together towards a big goal - map the entire mammalian brain in a way the world had never seen.
🧠📈 #OpenScienceWeek
Reposted by Marie Carlén
This is what can be achieved today due to longstanding federal support of academic basic science alongside close partnership of universities, private industry and NIH intramural initiatives. An ecosystem worth not just saving but doubling down on!
innovativegenomics.org/news/first-p...
innovativegenomics.org/news/first-p...
First Patient Treated with Personalized CRISPR Therapy, Developed in Just Six Months
The first on-demand CRISPR therapy for an infant with a rare metabolic disease developed by the IGI and collaborators around the world.
innovativegenomics.org
May 15, 2025 at 5:40 PM
This is what can be achieved today due to longstanding federal support of academic basic science alongside close partnership of universities, private industry and NIH intramural initiatives. An ecosystem worth not just saving but doubling down on!
innovativegenomics.org/news/first-p...
innovativegenomics.org/news/first-p...
We are hiring a research assistant! Come join our ongoing project investigating the PFC-striatum pathway in cognitive flexibility. Head-fixed behavior, Neuropixels, optogenetics, and viral circuit tracing etc ki.varbi.com/en/what:job/.... Please spread.
Research Assistant in Neuroscience
Do you want to contribute to top quality medical research? The position regards experimental research in the laboratory of Professor Marie Carlén in the Department of Neuroscience. Utilizing a sy
ki.varbi.com
February 24, 2025 at 4:42 AM
We are hiring a research assistant! Come join our ongoing project investigating the PFC-striatum pathway in cognitive flexibility. Head-fixed behavior, Neuropixels, optogenetics, and viral circuit tracing etc ki.varbi.com/en/what:job/.... Please spread.
Reposted by Marie Carlén
first thing to share here!
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Progressive degeneration of dopamine neurons (DANs) defines Parkinson's disease (PD). However, the identity and function of the most vulnerable DAN populations in prodromal PD remain undefined. Here, ...
www.biorxiv.org
December 22, 2024 at 10:43 PM
first thing to share here!
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
My first on BlueSky! 5 yrs in the making, a new view on the mouse PFC, based on activity
Our new study is out on BioRXiv!
tinyurl.com/pfcmap
We (@carlenlab.bsky.social lab) mapped the mouse PFC using single-unit activity! We recorded ~23,000 neurons across cortical/subcortical regions and profiled spont. firing patterns to reveal what separates the PFC from other brain regions.
1/n
tinyurl.com/pfcmap
We (@carlenlab.bsky.social lab) mapped the mouse PFC using single-unit activity! We recorded ~23,000 neurons across cortical/subcortical regions and profiled spont. firing patterns to reveal what separates the PFC from other brain regions.
1/n
A Prefrontal Cortex Map based on Single Neuron Activity
The intrinsic organization underlying the central cognitive role of the prefrontal cortex (PFC) is poorly understood. The work to date has been dominated by cytoarchitecture as a canvas for studies on...
www.biorxiv.org
November 25, 2024 at 3:07 PM
My first on BlueSky! 5 yrs in the making, a new view on the mouse PFC, based on activity