@canaanlab.bsky.social
TB and related mycobacteria, Mycobacterial lipids, infection, development of new drugs, diagnosis and more
Once again a great collaboration with @ibmm-balard.bsky.social @map-proteomique.bsky.social and other !!!
Today is a great day!
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...
👉 onlinelibrary.wiley.com/doi/10.1002/...
Our article accepted on March 19, 2025 is published in Wiley mLife journal.
Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social
Céline Crauste from @ibmm-balard.bsky.social, and more...
👉 onlinelibrary.wiley.com/doi/10.1002/...
The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae
Gram-negative bacteria are particularly prone to developing antimicrobial resistance (AMR), as evidenced by the WHO's ESKAPEE list of high-priority pathogens. One strategy that has increased is the u...
onlinelibrary.wiley.com
June 25, 2025 at 1:58 PM
Once again a great collaboration with @ibmm-balard.bsky.social @map-proteomique.bsky.social and other !!!
Reposted
Honored to award the title of Dr. honoris causa of the University of Toulouse to Dr. Manjula Reddy (CCMB, Hyderabad).
A world-renowned microbiologist, Dr. Reddy has made major contributions to our understanding of bacterial cell division. 🇫🇷🇮🇳
A world-renowned microbiologist, Dr. Reddy has made major contributions to our understanding of bacterial cell division. 🇫🇷🇮🇳
June 17, 2025 at 6:44 PM
Honored to award the title of Dr. honoris causa of the University of Toulouse to Dr. Manjula Reddy (CCMB, Hyderabad).
A world-renowned microbiologist, Dr. Reddy has made major contributions to our understanding of bacterial cell division. 🇫🇷🇮🇳
A world-renowned microbiologist, Dr. Reddy has made major contributions to our understanding of bacterial cell division. 🇫🇷🇮🇳
Reposted
It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊
pubs.acs.org/doi/10.1021/...
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊
pubs.acs.org/doi/10.1021/...
Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes
Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...
pubs.acs.org
May 29, 2025 at 1:11 PM
It is my real pleasure to share our ASAP article published in ACS Infect Dis.
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊
pubs.acs.org/doi/10.1021/...
Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social
@lkremer1.bsky.social
@ibmm-balard.bsky.social
@map-proteomique.bsky.social
and more...
Enjoy 😊
pubs.acs.org/doi/10.1021/...
Reposted
We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social
⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus
The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...
pubs.rsc.org
April 29, 2025 at 4:59 PM
We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social
Reposted
⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus
The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...
pubs.rsc.org
April 25, 2025 at 7:19 PM
⚠️ Breaking News ⚠️
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
Another great collaborative work with Victoria Magrioti,
@canaanlab.bsky.social @map-proteomique.bsky.social
now just published in @rscmedchem.rsc.org
pubs.rsc.org/en/content/a...
A new story on antimicrobial peptides published with great collaborators !!
Happy to share our new article in Current Research in Microbial Sciences @canaanlab.bsky.social
Nice work with Priscille Brodin, Aurelie Tasiemski, Celine Boidin-Wichlacz @pasteurlille.bsky.social, and more, on the use of antimicrobial peptides against Mtb.
www.sciencedirect.com/science/arti...
Nice work with Priscille Brodin, Aurelie Tasiemski, Celine Boidin-Wichlacz @pasteurlille.bsky.social, and more, on the use of antimicrobial peptides against Mtb.
www.sciencedirect.com/science/arti...
Potency of all-D amino acid antimicrobial peptides derived from the bovine rumen microbiome on tuberculous and non-tuberculous mycobacteria
Despite the availability of antibiotics, tuberculosis (TB), caused by Mycobacterium tuberculosis, was once again declared the world's leading cause of…
www.sciencedirect.com
April 22, 2025 at 8:03 PM
A new story on antimicrobial peptides published with great collaborators !!
Reposted
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
jobs.ncl.ac.uk
April 9, 2025 at 12:29 PM
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Reposted
Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social
Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
February 27, 2025 at 1:56 PM
Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social
Great job !!👏👏👏👏to all authors !
Happy to let you know that our most recent paper describing the discovery, structure and biological functions of a new glycolipid in M. abscessus is now out ! This has only be possible thanks to a wonderful collaboration with the teams of JL Herrmann and Y Guerardel.
rdcu.be/egVwe
rdcu.be/egVwe
April 10, 2025 at 3:41 PM
Great job !!👏👏👏👏to all authors !
Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social
Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
February 27, 2025 at 1:56 PM
Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social
Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...
A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio
This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identifying the proteins involved in the formation of ...
journals.asm.org
February 25, 2025 at 6:20 PM
Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...
Nice work congratulations Alexandre and co authors 👏👏👏
A very special one. My dear friends @healycl.bsky.social and @alexandregouzy.bsky.social published a paper with our common mentor @saehrt.bsky.social. On top of that, this is Alex’ first corresponding authorship!! And, of course, excellent bacterial physiology science.
Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
December 9, 2024 at 7:07 AM
Nice work congratulations Alexandre and co authors 👏👏👏
You are perfectly right !!! Authors please do not use this nomenclature anymore !!!!
When the title of a paper makes it painfully clear that no expert in the field was involved in its review...
Bravo #MolecularMicroEditors 👏
#PeerReview #MicroSky
onlinelibrary.wiley.com/doi/abs/10.1...
Bravo #MolecularMicroEditors 👏
#PeerReview #MicroSky
onlinelibrary.wiley.com/doi/abs/10.1...
ClpS Directs Degradation of N‐Degron Substrates With Primary Destabilizing Residues in Mycolicibacterium smegmatis
Many bacteria possess an N-degron pathway that links the proteolytic stability of proteins to the identity of their N-terminal residue. Here, we report that Mycolicibacterium smegmatis possesses a ph...
onlinelibrary.wiley.com
December 9, 2024 at 7:06 AM
You are perfectly right !!! Authors please do not use this nomenclature anymore !!!!
Reposted
Happy that @map-proteomique.bsky.social has participated oh this nice story from @canaanlab.bsky.social in collaboration with @lkremer1.bsky.social @pierresantucci.bsky.social @jefcavalier.bsky.social link.springer.com/article/10.1...
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science
Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...
link.springer.com
December 4, 2024 at 5:55 PM
Happy that @map-proteomique.bsky.social has participated oh this nice story from @canaanlab.bsky.social in collaboration with @lkremer1.bsky.social @pierresantucci.bsky.social @jefcavalier.bsky.social link.springer.com/article/10.1...
Reposted
After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives
@pierresantucci.bsky.social
@canaanlab.bsky.social
and more
febs.onlinelibrary.wiley.com/doi/10.1002/...
@pierresantucci.bsky.social
@canaanlab.bsky.social
and more
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti-inflammatory drug aspirin (ASP), are anti-TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacter...
febs.onlinelibrary.wiley.com
December 4, 2024 at 7:32 AM
After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives
@pierresantucci.bsky.social
@canaanlab.bsky.social
and more
febs.onlinelibrary.wiley.com/doi/10.1002/...
@pierresantucci.bsky.social
@canaanlab.bsky.social
and more
febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted
Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out!
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science
Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...
jbiomedsci.biomedcentral.com
December 3, 2024 at 9:15 AM
Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out!
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
Happy to share scientific @pierresantucci.bsky.social paper useful to facilitate screening of CrispRi mutants @Febs letters
Doi: 10.1002/1873-3468.15071
Doi: 10.1002/1873-3468.15071
December 2, 2024 at 3:26 PM
Happy to share scientific @pierresantucci.bsky.social paper useful to facilitate screening of CrispRi mutants @Febs letters
Doi: 10.1002/1873-3468.15071
Doi: 10.1002/1873-3468.15071
Reposted
Interesting paper showing different M tuberculosis strains induce varying levels of IL-1beta via inflammasome activation.
Curious to understand how that relates to infection clearance & disease severity.
#TBSky #IDSky #ImmunoSky #Immunometabolism
Curious to understand how that relates to infection clearance & disease severity.
#TBSky #IDSky #ImmunoSky #Immunometabolism
Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring
The glycolytic pathway is required for maximum IL-1β production by macrophages infected with live distinct M. tuberculosis isolates, but mitochondria metab
academic.oup.com
November 25, 2024 at 9:28 PM
Interesting paper showing different M tuberculosis strains induce varying levels of IL-1beta via inflammasome activation.
Curious to understand how that relates to infection clearance & disease severity.
#TBSky #IDSky #ImmunoSky #Immunometabolism
Curious to understand how that relates to infection clearance & disease severity.
#TBSky #IDSky #ImmunoSky #Immunometabolism