Jeff Calhoun
@calhoujd.bsky.social
Research Assistant Professor with Gemma Carvill (@CarvillLab on Twitter). Focus: epilepsy genetics. Twin. Ace cat dad. Occasional writer. I am only an egg. He/him.
Pinned
Jeff Calhoun
@calhoujd.bsky.social
· May 25
CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...
@coachnelly.bsky.social caught Oki Oki FC vod today. Awesome to see your progress, keep it up!
October 11, 2025 at 12:50 AM
@coachnelly.bsky.social caught Oki Oki FC vod today. Awesome to see your progress, keep it up!
Reposted by Jeff Calhoun
📣New today!
📄Landscapes of missense variant impact for human superoxide dismutase 1
🧑🤝🧑 @axakova.bsky.social @fritzroth.bsky.social & co
📄Landscapes of missense variant impact for human superoxide dismutase 1
🧑🤝🧑 @axakova.bsky.social @fritzroth.bsky.social & co
Landscapes of missense variant impact for human superoxide dismutase 1
SOD1 variants cause the motor neuron disease amyotrophic lateral sclerosis. Axakova
et al. functionally assay ∼86% of all possible SOD1 missense variants, producing a
variant-effect map resource that ...
www.cell.com
September 15, 2025 at 4:07 PM
📣New today!
📄Landscapes of missense variant impact for human superoxide dismutase 1
🧑🤝🧑 @axakova.bsky.social @fritzroth.bsky.social & co
📄Landscapes of missense variant impact for human superoxide dismutase 1
🧑🤝🧑 @axakova.bsky.social @fritzroth.bsky.social & co
Reposted by Jeff Calhoun
Just a reminder to check for your name in this list of books that OpenAI trained from. If your name is there, they probably owe you several thousand dollars.
OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.
OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.
Search LibGen, the Pirated-Books Database That Meta Used to Train AI
Millions of books and scientific papers are captured in the collection’s current iteration.
www.theatlantic.com
September 6, 2025 at 6:31 AM
Just a reminder to check for your name in this list of books that OpenAI trained from. If your name is there, they probably owe you several thousand dollars.
OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.
OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.
Reposted by Jeff Calhoun
#PAXWest 2025 is a gaming paradise spread across three buildings! Here’s a quick look at how to get around and enter each building.
For more maps & entry details visit PAXwest25.com/Maps
For more maps & entry details visit PAXwest25.com/Maps
August 26, 2025 at 7:00 PM
#PAXWest 2025 is a gaming paradise spread across three buildings! Here’s a quick look at how to get around and enter each building.
For more maps & entry details visit PAXwest25.com/Maps
For more maps & entry details visit PAXwest25.com/Maps
I don't work with fruit flies but even I know how important FlyBase is. Such sad news. 😞
August 14, 2025 at 12:14 PM
I don't work with fruit flies but even I know how important FlyBase is. Such sad news. 😞
Reposted by Jeff Calhoun
EpiPred: A gene-specific machine learning model for classifying missense variants in the epilepsy-related gene STXBP1 https://www.biorxiv.org/content/10.1101/2025.08.09.669488v1
August 11, 2025 at 7:32 AM
EpiPred: A gene-specific machine learning model for classifying missense variants in the epilepsy-related gene STXBP1 https://www.biorxiv.org/content/10.1101/2025.08.09.669488v1
Reposted by Jeff Calhoun
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
1/9
1/9
July 7, 2025 at 2:44 AM
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
1/9
1/9
Reposted by Jeff Calhoun
I couldn't sleep last night and skimmed through the names on the #BethesdaDeclaration support letter page.
First, the good news.
(1) There were 18,000+ names and it took me 3 hours.
1/n
First, the good news.
(1) There were 18,000+ names and it took me 3 hours.
1/n
June 12, 2025 at 5:28 PM
I couldn't sleep last night and skimmed through the names on the #BethesdaDeclaration support letter page.
First, the good news.
(1) There were 18,000+ names and it took me 3 hours.
1/n
First, the good news.
(1) There were 18,000+ names and it took me 3 hours.
1/n
Reposted by Jeff Calhoun
Thank you to all who joined us in person or online for #VariantEffect25 🌟
📺 Symposium talks are now available on our Youtube channel www.youtube.com/@cmap_cegs8443
📺 Symposium talks are now available on our Youtube channel www.youtube.com/@cmap_cegs8443
June 6, 2025 at 3:37 PM
Thank you to all who joined us in person or online for #VariantEffect25 🌟
📺 Symposium talks are now available on our Youtube channel www.youtube.com/@cmap_cegs8443
📺 Symposium talks are now available on our Youtube channel www.youtube.com/@cmap_cegs8443
Reposted by Jeff Calhoun
See our new paper in @ajhgnews.bsky.social :
Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists
Explores blocks to implementing MAVE data into clinical variant interpretation @varianteffect.bsky.social
authors.elsevier.com/a/1lDFkgeXDyy6
Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists
Explores blocks to implementing MAVE data into clinical variant interpretation @varianteffect.bsky.social
authors.elsevier.com/a/1lDFkgeXDyy6
June 6, 2025 at 8:34 AM
See our new paper in @ajhgnews.bsky.social :
Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists
Explores blocks to implementing MAVE data into clinical variant interpretation @varianteffect.bsky.social
authors.elsevier.com/a/1lDFkgeXDyy6
Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists
Explores blocks to implementing MAVE data into clinical variant interpretation @varianteffect.bsky.social
authors.elsevier.com/a/1lDFkgeXDyy6
@kathleen.loadingreadyrun.com Hi Kathleen, on recent TTC Q&A you mentioned sharing a curated lofi beats playlist with @coachnelly.bsky.social any chance you’d share here on blusky too? thanks!! 🙏
June 3, 2025 at 11:47 AM
@kathleen.loadingreadyrun.com Hi Kathleen, on recent TTC Q&A you mentioned sharing a curated lofi beats playlist with @coachnelly.bsky.social any chance you’d share here on blusky too? thanks!! 🙏
Hey @plasmidsaurus.bsky.social, have you heard of DinoCon? 🦖🦕
Things #DinoCon are REALLY coming along as ticket sales have gone into overdrive. Schedule out; most presenters and speakers have now been announced. The biggest and best dinosaur-themed meeting the UK has EVER seen, join us at the University of Exeter, Aug 16th and 17th. Book now: www.dinocon.co.uk
DinoCon
www.dinocon.co.uk
June 3, 2025 at 10:37 AM
Hey @plasmidsaurus.bsky.social, have you heard of DinoCon? 🦖🦕
Reposted by Jeff Calhoun
How bad will it be? Catastrophic.
Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.
But, this is the WH's *proposed* budget.
Speak up now before it is too late.
(inflation adjusted $-s below)
Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.
But, this is the WH's *proposed* budget.
Speak up now before it is too late.
(inflation adjusted $-s below)
May 31, 2025 at 2:50 AM
Reposted by Jeff Calhoun
Very excited about latest report from @igorulitsky.bsky.social's lab
using an ASO to upregulate CHD2 expression!
using an ASO to upregulate CHD2 expression!
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression
Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...
biorxiv.org
May 30, 2025 at 4:03 PM
Very excited about latest report from @igorulitsky.bsky.social's lab
using an ASO to upregulate CHD2 expression!
using an ASO to upregulate CHD2 expression!
Reposted by Jeff Calhoun
CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...
May 25, 2025 at 2:57 PM
CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...
CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...
May 25, 2025 at 2:57 PM
CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...
@tychobrahe.bsky.social Have you been keeping tabs on Monster Train 2? Curious to hear your thoughts at some point!
May 21, 2025 at 5:31 PM
@tychobrahe.bsky.social Have you been keeping tabs on Monster Train 2? Curious to hear your thoughts at some point!
Sometimes I clone with 5+ year expired NEB enzymes just to feel something.
a cartoon character says let 's in front of a green wall
ALT: a cartoon character says let 's in front of a green wall
media.tenor.com
May 20, 2025 at 11:31 AM
Sometimes I clone with 5+ year expired NEB enzymes just to feel something.
Reposted by Jeff Calhoun
We are continuing to look into grant terminations at the NIH, and we want to hear from you.
Please reach out to us with your experiences: www.propublica.org/getinvolved/...
Please reach out to us with your experiences: www.propublica.org/getinvolved/...
Did You Work on a Terminated NIH Grant? ProPublica Wants to Hear From You.
The National Institutes of Health is canceling grants that are seen as conflicting with the Trump administration’s priorities. We want to hear from researchers who have been affected.
www.propublica.org
May 7, 2025 at 10:18 PM
We are continuing to look into grant terminations at the NIH, and we want to hear from you.
Please reach out to us with your experiences: www.propublica.org/getinvolved/...
Please reach out to us with your experiences: www.propublica.org/getinvolved/...
Reposted by Jeff Calhoun
Bravo to ASCB, FASEB, and others for standing up for MOSAIC and other wrongfully terminated programs! 🙌🏾
Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration.
www.ascb.org/society-news...
www.ascb.org/society-news...
Leading Life Science Organizations: Unlawful Grant Terminations Pose Grave Threat to America’s Innovation Pipeline - ASCB
Amicus Brief Filed in Support of Suit Calling for Immediate Funding Restoration WASHINGTON, DC – Four leading life science organizations, including the ASCB, filed an amicus brief today asking the cou...
www.ascb.org
May 2, 2025 at 9:12 PM
Bravo to ASCB, FASEB, and others for standing up for MOSAIC and other wrongfully terminated programs! 🙌🏾
Reposted by Jeff Calhoun
Cannot emphasize this too strongly.
So: In 2017, Congress made this happen:
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
May 2, 2025 at 9:25 PM
Cannot emphasize this too strongly.
Reposted by Jeff Calhoun
Reposted by Jeff Calhoun
Tax Day - round 3 - NIH 🩻🧠🧬
🧬 The average U.S. taxpayer contributes $105/year to NIH, helping fund:
• Cancer & rare disease breakthroughs
• Pandemic preparedness
• Children’s health
• Medical tech innovation
• Mental health science & more
NIH powers the science behind the healthcare we rely on.
🧬 The average U.S. taxpayer contributes $105/year to NIH, helping fund:
• Cancer & rare disease breakthroughs
• Pandemic preparedness
• Children’s health
• Medical tech innovation
• Mental health science & more
NIH powers the science behind the healthcare we rely on.
April 15, 2025 at 9:36 PM
Tax Day - round 3 - NIH 🩻🧠🧬
🧬 The average U.S. taxpayer contributes $105/year to NIH, helping fund:
• Cancer & rare disease breakthroughs
• Pandemic preparedness
• Children’s health
• Medical tech innovation
• Mental health science & more
NIH powers the science behind the healthcare we rely on.
🧬 The average U.S. taxpayer contributes $105/year to NIH, helping fund:
• Cancer & rare disease breakthroughs
• Pandemic preparedness
• Children’s health
• Medical tech innovation
• Mental health science & more
NIH powers the science behind the healthcare we rely on.
Reposted by Jeff Calhoun
As NIH and university funding in the US is dismantled and as this admin revokes international student visas for no reason…we need to make a stand. Thanks @ardemp.bskyverified.social for being vocal about what’s at stake! www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 4:36 PM
As NIH and university funding in the US is dismantled and as this admin revokes international student visas for no reason…we need to make a stand. Thanks @ardemp.bskyverified.social for being vocal about what’s at stake! www.cnn.com/2025/04/09/h...
Reposted by Jeff Calhoun
“To me, slashing funding and people from science in the United States is like burning your seed corn. It’s not even eating your seed corn. It’s just destroying it,”
www.theguardian.com/science/2025...
www.theguardian.com/science/2025...
Biologist whose innovation saved the life of British teenager wins $3m Breakthrough prize
Prof David Liu is among the winners of 2025’s ‘Oscars of science’, with honours also going to researchers for landmark work on multiple sclerosis, particle physics and ‘skinny jabs’
www.theguardian.com
April 6, 2025 at 6:19 AM
“To me, slashing funding and people from science in the United States is like burning your seed corn. It’s not even eating your seed corn. It’s just destroying it,”
www.theguardian.com/science/2025...
www.theguardian.com/science/2025...