Reposted by Vincent B
📣 I am excited to announce that I have joined the MBB department at Karolinska Institutet in Stockholm as an assistant professor.
See below for more details!
#wearehiring
See below for more details!
#wearehiring
October 21, 2025 at 4:24 PM
📣 I am excited to announce that I have joined the MBB department at Karolinska Institutet in Stockholm as an assistant professor.
See below for more details!
#wearehiring
See below for more details!
#wearehiring
Reposted by Vincent B
Are you a postdoc looking for a new challenge and do you match the profile? Apply to join us! Especially, if you have experience with addressing the mechanisms underlying telomere maintenance, DNA replication or DNA repair. www.werkenbijavl.nl/vacatures/po...
Postdoc - Telomere and Genome Maintenance | Werken bij AVL
The research group of Jacqueline Jacobs at the division of Oncogenomics aims to identify new factors and molecular mechanisms that are critical in telomere and genome maintenance through appropriate D...
www.werkenbijavl.nl
October 6, 2025 at 1:25 PM
Are you a postdoc looking for a new challenge and do you match the profile? Apply to join us! Especially, if you have experience with addressing the mechanisms underlying telomere maintenance, DNA replication or DNA repair. www.werkenbijavl.nl/vacatures/po...
Reposted by Vincent B
🧬 Hubrecht researchers have developed a method that can detect DNA methylation and histone modifications simultaneously in single cells. They can now for the first time study how their interaction influences gene activity. https://www.nature.com/articles/s41592-025-02847-4
@jervdberg.bsky.social
@jervdberg.bsky.social
September 25, 2025 at 9:04 AM
🧬 Hubrecht researchers have developed a method that can detect DNA methylation and histone modifications simultaneously in single cells. They can now for the first time study how their interaction influences gene activity. https://www.nature.com/articles/s41592-025-02847-4
@jervdberg.bsky.social
@jervdberg.bsky.social
Reposted by Vincent B
New method 🚀: scEpi2-seq lets us read DNA methylation+histone marks in the same single cell. Found that methylation “memory” after replication depends on chromatin+histones, and TF promoters repressed by H3K27me3 carry distinct methylation. So stoked to share this as first+co-corresponding author 🎉
September 25, 2025 at 9:02 AM
New method 🚀: scEpi2-seq lets us read DNA methylation+histone marks in the same single cell. Found that methylation “memory” after replication depends on chromatin+histones, and TF promoters repressed by H3K27me3 carry distinct methylation. So stoked to share this as first+co-corresponding author 🎉
Reposted by Vincent B
Come visit my poster #3195 tomorrow, so I can tell you about the method we recently developed to study DNA replication dynamics and replication stress in hematopoietic tissues!
September 24, 2025 at 1:32 PM
Come visit my poster #3195 tomorrow, so I can tell you about the method we recently developed to study DNA replication dynamics and replication stress in hematopoietic tissues!
Reposted by Vincent B
Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
September 9, 2025 at 4:05 PM
Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
Reposted by Vincent B
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
rdcu.be
September 1, 2025 at 10:04 AM
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
Reposted by Vincent B
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
RNA transcripts regulate G-quadruplex landscapes through G-loop formation
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
www.science.org
June 13, 2025 at 9:33 AM
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
Reposted by Vincent B
🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute
About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...
shorturl.at
May 20, 2025 at 10:20 AM
🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!
Reposted by Vincent B
### PhD position alert ###
Please repost!
I'm excited to announce a new *PhD position* within our group.
We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!
werkenbijprinsesmaximacentrum.nl/en/vacancy/p...
Please repost!
I'm excited to announce a new *PhD position* within our group.
We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!
werkenbijprinsesmaximacentrum.nl/en/vacancy/p...
PhD Position: Unraveling the Dark Proteome in Pediatric Cancer - Werken bij Prinses Maxima Centrum
Background For decades, vast stretches of the genome were dismissed as non-functional ‘junk’. However, our group and others have revealed that these regions harbor numerous non-canonical open reading ...
werkenbijprinsesmaximacentrum.nl
May 16, 2025 at 9:04 AM
### PhD position alert ###
Please repost!
I'm excited to announce a new *PhD position* within our group.
We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!
werkenbijprinsesmaximacentrum.nl/en/vacancy/p...
Please repost!
I'm excited to announce a new *PhD position* within our group.
We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!
werkenbijprinsesmaximacentrum.nl/en/vacancy/p...
Reposted by Vincent B
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute
About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...
shorturl.at
May 16, 2025 at 7:45 AM
🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Come work in our collaberative team of top scientists
shorturl.at/avBBy
Reposted by Vincent B
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
doi.org
May 4, 2025 at 7:39 AM
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Reposted by Vincent B
Pre-print alert!! Did you know that exploration of loss and gain of eQTL regulation in normal versus disease condition from scRNAseq can reveal pos-transcriptional regulatory mechanisms (e.g. miRNA)? Have a look at our work, led by awesome @tdwinter.bsky.social, in which we focus on human islets.
January 27, 2025 at 8:28 AM
Pre-print alert!! Did you know that exploration of loss and gain of eQTL regulation in normal versus disease condition from scRNAseq can reveal pos-transcriptional regulatory mechanisms (e.g. miRNA)? Have a look at our work, led by awesome @tdwinter.bsky.social, in which we focus on human islets.
Reposted by Vincent B
Several new technologies have enabled translation profiling in single cells. In our article in @natrevmcb.bsky.social, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵 www.nature.com/articles/s41...
Sequencing technologies to measure translation in single cells - Nature Reviews Molecular Cell Biology
Recent sequencing-based methods, including novel ribosome profiling, ribosome affinity purification and spatial translation methods, have enabled the measurement of translation at single-cell resoluti...
www.nature.com
January 23, 2025 at 8:16 PM
Several new technologies have enabled translation profiling in single cells. In our article in @natrevmcb.bsky.social, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵 www.nature.com/articles/s41...