Burkard Lab
@burkardlab.bsky.social
Burkard Lab | Holden Comprehensive Cancer Center | University of Iowa
Studying chromosomal instability, mitotic regulation & cancer evolution
Directed by Dr. Mark E. Burkard
Studying chromosomal instability, mitotic regulation & cancer evolution
Directed by Dr. Mark E. Burkard
Pinned
Burkard Lab
@burkardlab.bsky.social
· Sep 12
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
Reposted by Burkard Lab
We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 [email protected]
📅 Apply by 3/1/26
📧 [email protected]
Postdoc Opportunities
Open postdoc positions are listed in the interactive table below. The table is best viewed in landscape mode if on a mobile device. Use the search box to narrow your search. Click on the column header...
pob.wisc.edu
September 17, 2025 at 6:35 PM
We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 [email protected]
📅 Apply by 3/1/26
📧 [email protected]
Reposted by Burkard Lab
Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology
One step 4× and 12× 3D-ExM enables robust super-resolution microscopy of nanoscale cellular structures | Journal of Cell Biology | Rockefeller University Press
The 4× and 12× 3D-ExM methods were optimized for super-resolution expansion microscopy, offering a one-step expansion process without the need for speciali
rupress.org
September 14, 2025 at 7:20 PM
Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology
Reposted by Burkard Lab
Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
The reckoning of chromosomal instability: past, present, future - Chromosome Research
Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we re...
link.springer.com
September 14, 2025 at 7:29 PM
Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
Reposted by Burkard Lab
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 14, 2025 at 7:36 PM
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Burkard Lab
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
September 12, 2025 at 9:24 PM
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 [email protected]
📅 Apply by 3/1/26
📧 [email protected]
Postdoc Opportunities
Open postdoc positions are listed in the interactive table below. The table is best viewed in landscape mode if on a mobile device. Use the search box to narrow your search. Click on the column header...
pob.wisc.edu
September 17, 2025 at 6:35 PM
We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 [email protected]
📅 Apply by 3/1/26
📧 [email protected]
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 14, 2025 at 7:36 PM
Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
The reckoning of chromosomal instability: past, present, future - Chromosome Research
Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we re...
link.springer.com
September 14, 2025 at 7:29 PM
Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology
Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology
One step 4× and 12× 3D-ExM enables robust super-resolution microscopy of nanoscale cellular structures | Journal of Cell Biology | Rockefeller University Press
The 4× and 12× 3D-ExM methods were optimized for super-resolution expansion microscopy, offering a one-step expansion process without the need for speciali
rupress.org
September 14, 2025 at 7:20 PM
Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology
New from the Burkard Lab: Polo-like kinase 1 maintains transcription & chromosomal accessibility during mitosis.We show PLK1 is vital not just for mitotic machinery but for keeping promoter/TSS regions accessible & transcription active. Check it out www.molbiolcell.org/doi/10.1091/... #mitosis #plk1
Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis | Molecular Biology of the Cell
Transcription persists at low levels in mitotic cells and plays essential roles in mitotic fidelity and chromosomal dynamics. However, the detailed regulatory network of mitotic transcription remains ...
www.molbiolcell.org
September 14, 2025 at 7:17 PM
New from the Burkard Lab: Polo-like kinase 1 maintains transcription & chromosomal accessibility during mitosis.We show PLK1 is vital not just for mitotic machinery but for keeping promoter/TSS regions accessible & transcription active. Check it out www.molbiolcell.org/doi/10.1091/... #mitosis #plk1
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
September 12, 2025 at 9:24 PM
👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!