This is a great idea! I really enjoy the JI Pillar articles

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.

It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

gavage with Listeria leads to rapid (within 4 hour dissemination to the liver) but feeding takes 48 hours and appears to pass through the MLN. We thought this was a technical limitation of gavage but perhaps it's different with Yersinia.

Thanks for sharing and best of luck with submission!

Okay, that sounds great. So, how do you think this works? The ole direct access to the hepatic portal vein? Shouldn't that require pass through though? We've been struggling with these questions in the Listeria system for some time. But...

Very cool study! Curious if you looked at foodborne infection instead of gavage using this approach to compare splenic/liver vs intestinal founders?

Will do. Just switched over from the other place a few weeks back.