It's a great series!

I think these are similar: www.emsdiasum.com/secure-seal-...

Also, we've used 3D printing to make microchambers for mammalian cell microscopy and recently have experimented with printing directly onto glass - that may be an alternative as well.

That's pretty cool!

It's unethical (& in most jurisdictions, illegal) to include people in trials who are at a high known risk for adverse events. That said, the trial size is more than large enough to capture MCAS at rates noted in COVID patient cohorts.

The work you "wish" would be done is, and has been, done. For decades (in general) and since the early 2000s for mRNA vaccines specifically. The issue isn't that this work isn't being done - it's that you're not aware of this work and therefore assumed incorrectly that no one is doing it. /end

You stated that a rare side effect has only been known about for 15 years and therefore not enough research has been done. In reality, it's been investigated for nearly 50 years to the tune of over 800 studies. /1

It's almost as though we know about these things and monitor for them specifically in trials...how strange.

And there are people who explicitly and specifically study these topics. But trying to pretend that this work hasn't been ongoing for over 30 years is both a lie and a disservice to the massive amount of work already done on the field. Shifting the goalposts doesn't change that.

As medical science advances we can often more finely divide patients into distinct diagnostic categories, but the invention of a new category does not mean that the (often decades of) work leading up to that new categorization is irrelevant or outdated.

That is incorrect. Mast Cell Activation Syndrome was first proposed as a separate condition from idiopathic anaphylaxis by Stoloff et al in 1992, with the first treatment proposals put forward in 1995 by Murray et al. Research into idiopathic anaphylaxis go back to the 1970s. /1

They do study the side effects. mRNA vaccines have been in development since the 1980's, with the first human trials occuring over 25 years ago. Much of that research was into side effects and other potential risks. There are literally hundreds of scientific studies on this topic.

I apparently got my PhD so that, after I do something particularly stupid, my wife can give me a long stare and say "good job, doctor Heit".

We can still bring in international students, but not as many as in the past (nor as many as most universities planned for). The cap includes MSc and PhD students, so visa availability is down across the board.

I'm not sure website views are a meaningful metric. Regardless, at an undergrad/grad level, Canada has reduced student visas which has reduced international student enrollment.

Not exactly. Operating funds to provide undergraduate educational programs is mostly provincial. Money that supports scientific research is almost entierly federal - by a factor of 10:1, if not more

While I've never seen the supreme court in action, I did have the unfortunate experience of serving on a provincial court jury last year. That experience didn't exactly give me faith in the robustness of our justice system, nor in the capabilities of our judges.

I'm torn, as being hurried with cheese still tops my list. It's a gouda way to go.

www.cnn.com/2024/09/25/s...