Brian Liau
@brianliau.bsky.social
Chemical biologist broadly defined
In collaboration with @mattevilab.bsky.social, we share in @naturecomms.bsky.social our work studying the mechanism of LSD1 covalent ‘formylators’. Many LSD1 inhibitors create a bulky FAD-drug adduct. Discovered by Takeda by phenotypic screening, these formylators serendipitously create formyl-FAD.
April 3, 2025 at 12:00 PM
In collaboration with @mattevilab.bsky.social, we share in @naturecomms.bsky.social our work studying the mechanism of LSD1 covalent ‘formylators’. Many LSD1 inhibitors create a bulky FAD-drug adduct. Discovered by Takeda by phenotypic screening, these formylators serendipitously create formyl-FAD.
Taken together, this paradigm of chemical-genetic convergence raises the broader prospect that we can use mutational scanning approaches to uncover glue-able and/or functional protein sites to then prioritize for small molecule development. 4/5
February 12, 2025 at 4:20 PM
Taken together, this paradigm of chemical-genetic convergence raises the broader prospect that we can use mutational scanning approaches to uncover glue-able and/or functional protein sites to then prioritize for small molecule development. 4/5
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5