Baptiste Libé-Philippot
@blibep.bsky.social
Neurobiologist | "Human Neuronal Evolution" Team leader @ibdm.bsky.social @cnrs.fr @univ-amu.fr 🇫🇷 | @erc.europa.eu StG 2024 🇪🇺 | @normalesup.bsky.social @pasteur.fr @cbdresearch.bsky.social Alumnus. Opinions are my own. https://neurobiologieetsociete.org/
🔬How humans can study their own brain? Answering this question necessitates multimodal and multiscale approaches, among them human brain tissue, the topic of this issue.Every biological technology and approach cannot be accessible by each of those approaches on its own.
October 2, 2025 at 7:28 AM
🔬How humans can study their own brain? Answering this question necessitates multimodal and multiscale approaches, among them human brain tissue, the topic of this issue.Every biological technology and approach cannot be accessible by each of those approaches on its own.
🧪 Nice day yesterday in Luminy, Marseille 🇫🇷 at the occasion of the Symposium "Linking neural development, human disease and evolution"!
🧠Great talks from @sophiechauvet.bsky.social Francois Féron, @angofab.bsky.social, Vincent Cantagrel, @fekrijeselimi.bsky.social @franckp.bsky.social.
🧠Great talks from @sophiechauvet.bsky.social Francois Féron, @angofab.bsky.social, Vincent Cantagrel, @fekrijeselimi.bsky.social @franckp.bsky.social.
September 30, 2025 at 11:36 AM
🧪 Nice day yesterday in Luminy, Marseille 🇫🇷 at the occasion of the Symposium "Linking neural development, human disease and evolution"!
🧠Great talks from @sophiechauvet.bsky.social Francois Féron, @angofab.bsky.social, Vincent Cantagrel, @fekrijeselimi.bsky.social @franckp.bsky.social.
🧠Great talks from @sophiechauvet.bsky.social Francois Féron, @angofab.bsky.social, Vincent Cantagrel, @fekrijeselimi.bsky.social @franckp.bsky.social.
Nice talk from Ghislaine Dehaene-Lambertz on human baby neurodevelopment at @neuromarseille.bsky.social annual days!
September 18, 2025 at 4:38 PM
Nice talk from Ghislaine Dehaene-Lambertz on human baby neurodevelopment at @neuromarseille.bsky.social annual days!
Cap Croisette et Ile Maïre, Marseille, France
September 14, 2025 at 4:31 PM
Cap Croisette et Ile Maïre, Marseille, France
We were glad to receive @debbysilver.bsky.social 🇺🇸 for a @ibdm.bsky.social keynote lecture "The choreography of brain development: From RNA biology to evolution"!
Thank you for coming in Marseille! Very nice chats on neurodevelopment, human evolution, gene regulation! Food and sea also in the menu!
Thank you for coming in Marseille! Very nice chats on neurodevelopment, human evolution, gene regulation! Food and sea also in the menu!
September 13, 2025 at 4:52 PM
We were glad to receive @debbysilver.bsky.social 🇺🇸 for a @ibdm.bsky.social keynote lecture "The choreography of brain development: From RNA biology to evolution"!
Thank you for coming in Marseille! Very nice chats on neurodevelopment, human evolution, gene regulation! Food and sea also in the menu!
Thank you for coming in Marseille! Very nice chats on neurodevelopment, human evolution, gene regulation! Food and sea also in the menu!
Amazing week at the Cerebellum Gordon Conference! Happy to discover this community to study in a collaborative way this brain objet from molecules to models of cellular connectivity and development to human behavior. And the landscape in the Diablerets 🇨🇭 is beautiful!
July 13, 2025 at 9:24 AM
Amazing week at the Cerebellum Gordon Conference! Happy to discover this community to study in a collaborative way this brain objet from molecules to models of cellular connectivity and development to human behavior. And the landscape in the Diablerets 🇨🇭 is beautiful!
Merci au magazine Cerveau & Psycho @pourlascience.bsky.social de m'avoir proposé un interview, en kiosque cet été (juillet) !
🚲 🧠 Si vous voulez savoir en quoi les cerveaux des Vertébrés se ressemblent et diffèrent comme des bicyclette électrique, VTT, et VTC, c'est ici : lnkd.in/eQSkeH52 !
🚲 🧠 Si vous voulez savoir en quoi les cerveaux des Vertébrés se ressemblent et diffèrent comme des bicyclette électrique, VTT, et VTC, c'est ici : lnkd.in/eQSkeH52 !
June 10, 2025 at 10:04 AM
Merci au magazine Cerveau & Psycho @pourlascience.bsky.social de m'avoir proposé un interview, en kiosque cet été (juillet) !
🚲 🧠 Si vous voulez savoir en quoi les cerveaux des Vertébrés se ressemblent et diffèrent comme des bicyclette électrique, VTT, et VTC, c'est ici : lnkd.in/eQSkeH52 !
🚲 🧠 Si vous voulez savoir en quoi les cerveaux des Vertébrés se ressemblent et diffèrent comme des bicyclette électrique, VTT, et VTC, c'est ici : lnkd.in/eQSkeH52 !
🧠 Glad to have participated to the #NeuroDev event of @neuromarseille.bsky.social to discuss further the future. Looking forward to see stronger connections between clinicians and basic scientists and between the different scales of neuroscience! #NeuroDev rocks in #Marseille!
April 26, 2025 at 5:03 PM
🧠 Glad to have participated to the #NeuroDev event of @neuromarseille.bsky.social to discuss further the future. Looking forward to see stronger connections between clinicians and basic scientists and between the different scales of neuroscience! #NeuroDev rocks in #Marseille!
Spring in Erlangen 🇩🇪.
I was glad to have been invited to the symposium on "Developmental processes in CNS Plasticity and Pathogenesis" @dfg.de. First talk with preliminary data of our team!
Nice discussions with organizers, speakers and students!
👋🏻
@agneseloda.bsky.social @joadelas.bsky.social
I was glad to have been invited to the symposium on "Developmental processes in CNS Plasticity and Pathogenesis" @dfg.de. First talk with preliminary data of our team!
Nice discussions with organizers, speakers and students!
👋🏻
@agneseloda.bsky.social @joadelas.bsky.social
April 12, 2025 at 1:46 PM
Spring in Erlangen 🇩🇪.
I was glad to have been invited to the symposium on "Developmental processes in CNS Plasticity and Pathogenesis" @dfg.de. First talk with preliminary data of our team!
Nice discussions with organizers, speakers and students!
👋🏻
@agneseloda.bsky.social @joadelas.bsky.social
I was glad to have been invited to the symposium on "Developmental processes in CNS Plasticity and Pathogenesis" @dfg.de. First talk with preliminary data of our team!
Nice discussions with organizers, speakers and students!
👋🏻
@agneseloda.bsky.social @joadelas.bsky.social
🧪I love Figure 4 of the @geneontology.bsky.social logy.bsky.social article published in the @nature.com issue of this week. An insight on life gene evolution that shed light on human species evolution. To add in my next teaching presentation!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 3, 2025 at 7:55 AM
🧪I love Figure 4 of the @geneontology.bsky.social logy.bsky.social article published in the @nature.com issue of this week. An insight on life gene evolution that shed light on human species evolution. To add in my next teaching presentation!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧪 Happy New Year with these cerebellar Purkinje cells, emblematic of our "Human Neuronal Evolution" research team: www.ibdm.univ-amu.fr/team/human-n...!
January 2, 2025 at 1:32 PM
🧪 Happy New Year with these cerebellar Purkinje cells, emblematic of our "Human Neuronal Evolution" research team: www.ibdm.univ-amu.fr/team/human-n...!
Passionnant entretien entre Ghassan Salamé et Brigitte Curmi au théâtre de la Criée à Marseille, dans le cadre des rencontres Averroès.
Sur le conflit en Méditerranée, avec comme position du diplomate et enseignant qui "pense la violence".
www.nouvellesrencontresaverroes.com/soiree-spect...
Sur le conflit en Méditerranée, avec comme position du diplomate et enseignant qui "pense la violence".
www.nouvellesrencontresaverroes.com/soiree-spect...
November 23, 2024 at 8:51 PM
Passionnant entretien entre Ghassan Salamé et Brigitte Curmi au théâtre de la Criée à Marseille, dans le cadre des rencontres Averroès.
Sur le conflit en Méditerranée, avec comme position du diplomate et enseignant qui "pense la violence".
www.nouvellesrencontresaverroes.com/soiree-spect...
Sur le conflit en Méditerranée, avec comme position du diplomate et enseignant qui "pense la violence".
www.nouvellesrencontresaverroes.com/soiree-spect...
Interestingly, the same mechanism is found in mice: the mutually antagonistic interaction between postsynaptic proteins SRGAP2A and SYNGAP1, that sets the tempo of synaptic maturation, is conserved in mammals. Therefore, SRGAP2B/C are human modifiers of this ancestral mechanisms.
November 18, 2024 at 5:08 PM
Interestingly, the same mechanism is found in mice: the mutually antagonistic interaction between postsynaptic proteins SRGAP2A and SYNGAP1, that sets the tempo of synaptic maturation, is conserved in mammals. Therefore, SRGAP2B/C are human modifiers of this ancestral mechanisms.
SYNGAP1 gene haploinsufficiency is responsible for up to 1% of all cases of non-syndromic ID, frequently associated with ASD. Recent work showed that it leads to disrupted synaptic neoteny. This leads to impaired synaptic plasticity.
- doi.org/10.1016/j.ne...
- doi.org/10.1016/j.ne...
November 18, 2024 at 5:08 PM
SYNGAP1 gene haploinsufficiency is responsible for up to 1% of all cases of non-syndromic ID, frequently associated with ASD. Recent work showed that it leads to disrupted synaptic neoteny. This leads to impaired synaptic plasticity.
- doi.org/10.1016/j.ne...
- doi.org/10.1016/j.ne...
How does this work? We confirmed previous studies suggesting that SRGAP2B/C inhibit SRGAP2A synaptic accumulation. But more strikingly, we discovered a mutually antagonistic interaction between postsynaptic proteins SRGAP2A and SYNGAP1 that sets the tempo of synaptic maturation.
November 18, 2024 at 5:08 PM
How does this work? We confirmed previous studies suggesting that SRGAP2B/C inhibit SRGAP2A synaptic accumulation. But more strikingly, we discovered a mutually antagonistic interaction between postsynaptic proteins SRGAP2A and SYNGAP1 that sets the tempo of synaptic maturation.
But whether and how SRGAP2B/C play a critical role in synaptic neoteny, remained to be explored. Using our xenotransplantation model, SRGAP2B/C loss-of-function induced an acceleration of the synaptic maturation. After 18 months, densities are similar to those observed in 5/10-years-old humans!
November 18, 2024 at 5:08 PM
But whether and how SRGAP2B/C play a critical role in synaptic neoteny, remained to be explored. Using our xenotransplantation model, SRGAP2B/C loss-of-function induced an acceleration of the synaptic maturation. After 18 months, densities are similar to those observed in 5/10-years-old humans!
Previous studies showed that human cortical pyramidal neurons develop along a prolonged neotenic timescale when xenotransplanted in the fast-developing mouse cortex, that we confirmed for the synaptic development itself. These results point to species-specific, cell-intrinsic, mechanisms.
November 18, 2024 at 5:08 PM
Previous studies showed that human cortical pyramidal neurons develop along a prolonged neotenic timescale when xenotransplanted in the fast-developing mouse cortex, that we confirmed for the synaptic development itself. These results point to species-specific, cell-intrinsic, mechanisms.
A salient feature of human brain development is the considerably prolonged, or neotenic, tempo of cortical neuronal maturation, taking months to years in humans, instead of days to months observed in other mammals, leading to prolonged periods of synaptic plasticity.
doi.org/10.1146/annu...
doi.org/10.1146/annu...
November 18, 2024 at 5:08 PM
A salient feature of human brain development is the considerably prolonged, or neotenic, tempo of cortical neuronal maturation, taking months to years in humans, instead of days to months observed in other mammals, leading to prolonged periods of synaptic plasticity.
doi.org/10.1146/annu...
doi.org/10.1146/annu...
Blue Sky in the Calanque of Sugiton, Marseille.
November 16, 2024 at 4:46 PM
Blue Sky in the Calanque of Sugiton, Marseille.