Dave Blake
banner
blakestah.bsky.social
Dave Blake
@blakestah.bsky.social
Med School Professor. Brain Physiology researcher. Biomedical Engineer. Biomedical device work. I stimulate mammalian brains to improve cognition. OMHIWDMB.
So, consider a high amplitude dimension of the data that, once normalized, no longer fits in the top PCs. SVD would rank it highly, while PCA would not.
November 26, 2025 at 8:12 PM
So, SVD does not throw away the amplitude of each orthogonal contribution to the space.

PCA does.

There are times SVD will be much more useful than PCA for this reason.
November 26, 2025 at 5:44 PM
I am not even sure it is a hypothesis.

I mean, it is a certainty that neural activity coding for a behavior is not using the full subspace of coding available.

It is interesting how many dimensions are in use.

But these are almost mathematically guaranteed.

Can you state the hypothesis?
November 26, 2025 at 3:17 PM
On the other hand, googling "Brain Command Center" returns this

"... the prefrontal cortex acting as its "CEO" for higher-level thinking, and the hypothalamus serving as the "smart control center" for automatic bodily functions."
November 19, 2025 at 7:30 PM
It is inevitable that such controversies emerge from neuroscience. We are discovering less and less new each decade about how the brain works, and those working on questions central to understanding higher cognition (a noble task) sometimes form increasingly dubious hypotheses about what is new.
November 19, 2025 at 3:32 PM
They really underestimate the man-hours needed to renegotiate aims on 10-15k projects per year. Hours will need to be spent on each proposal by highly specialized experts.

What folly.
November 19, 2025 at 12:23 PM
I do not believe the text of the proposition supports that statement. The prop was motivated by Texas, but does not depend on it.
November 18, 2025 at 8:18 PM
Reposted by Dave Blake
I guess for some people, junior scientists are like eggs. If you have a dozen, you can break most of them because you only need a couple to produce an omelet.
November 17, 2025 at 7:57 PM
So sorry!
November 15, 2025 at 10:29 PM
The Office of the Clerk indicates the discharge petition has 218 signatures.

clerk.house.gov/DischargePet...
Discharge Petition No. 9, Bill Number: H.Res. 581, 119th Congress
SPONSOR: Thomas Massie DESCRIPTION: Pursuant to clause 2 of rule XV, I, Thomas Massie, move to discharge the Committee on Rules from the consideration of the resolution entitled, a resolution providi...
clerk.house.gov
November 12, 2025 at 9:37 PM
100%
November 10, 2025 at 8:16 PM
And on top of all that, there is one nation that is throwing everything they have at NHP research, and doing so at a SMALL fraction of the cost of doing the work in the USA.

We are not there yet, but it is inevitable that labs in the USA will not be able to stay competitive in this arena.

3/3
November 10, 2025 at 8:12 PM
And with the NIH administration, it would not be so far fetched for them to do something terminal, like, for example, withdraw core support from the 7 National Primate centers (more than one of which is already under attack from state/local government). Of course, there used to be more than 7.
2/
November 10, 2025 at 8:12 PM
The list of institutions supporting NHP research has been notably shrinking over the last 10 years. Including UCSF, for example!

The costs have skyrocketed.

And NHP grant proposals are getting irrational animal welfare concerns from non-NHP users who are unfamiliar with processes.
1/
November 10, 2025 at 8:12 PM
The ice is so thin right now....and could so easily be broken irreparably.
November 10, 2025 at 6:29 PM
The term I heard was "least publishable unit", which in the lab in which it wad used was often the acronym LPU.

The LPU was central to that lab's approach.
November 7, 2025 at 10:56 AM
It was a Novo Nordisk executive, representing a company that offers weight loss drugs. His name is Gordon Findlay, and I really hope he feels better!
November 6, 2025 at 9:49 PM