Björn Schumacher
@bjornschumacher.bsky.social
I'm a scientist 👨⚕️, author 📕and chair for genome stability in aging and disease at the University of Cologne. https://igsad.de
Metabolism and proteostasis are key mechanisms for slowing aging and transcription-coupled DNA repair restores a stable trancriptome during the rejuvenation process. Congratulations to Khrystyna Totska, João Barata, Walter Sandt and @meyerdh.bsky.social David Meyer for the great work
October 17, 2025 at 2:06 PM
Metabolism and proteostasis are key mechanisms for slowing aging and transcription-coupled DNA repair restores a stable trancriptome during the rejuvenation process. Congratulations to Khrystyna Totska, João Barata, Walter Sandt and @meyerdh.bsky.social David Meyer for the great work
The Dauer diapause is the most amazing natural adaptation of C. elegans that allows survival amid adverse environmental conditions. Despite being active the animals can rejuvenate during dauer exit and grow into fully functioning adults.
October 17, 2025 at 2:06 PM
The Dauer diapause is the most amazing natural adaptation of C. elegans that allows survival amid adverse environmental conditions. Despite being active the animals can rejuvenate during dauer exit and grow into fully functioning adults.
mproving the stability of the genome thus reducing mutation accumulation and enhancing the maintenance of functional genomes. Great collaboration with Arturo Bujarrabal,
@garinis.bsky.social, , Jan Vijg @cecad.bsky.social @uniklinikkoeln.bsky.social @unicologne.bsky.social
@garinis.bsky.social, , Jan Vijg @cecad.bsky.social @uniklinikkoeln.bsky.social @unicologne.bsky.social
September 30, 2025 at 3:24 PM
mproving the stability of the genome thus reducing mutation accumulation and enhancing the maintenance of functional genomes. Great collaboration with Arturo Bujarrabal,
@garinis.bsky.social, , Jan Vijg @cecad.bsky.social @uniklinikkoeln.bsky.social @unicologne.bsky.social
@garinis.bsky.social, , Jan Vijg @cecad.bsky.social @uniklinikkoeln.bsky.social @unicologne.bsky.social
The first master regulator of DNA repair capacities that could be therapeutically targeted is the DREAM complex as we show here: www.nature.com/articles/s41...
The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology
In this work, the authors show that the DREAM complex suppresses the expression of numerous DNA-repair proteins in somatic cells. Suppression of the DREAM complex, either by altering individual compon...
www.nature.com
September 20, 2025 at 5:25 AM
The first master regulator of DNA repair capacities that could be therapeutically targeted is the DREAM complex as we show here: www.nature.com/articles/s41...
For more on the central role of DNA damage in the aging process read here our review article in Nature @natureportfolio.nature.com www.nature.com/articles/s41...
The central role of DNA damage in the ageing process - Nature
This Review examines the evidence showing that DNA damage is associated with ageing phenotypes, suggesting that it may have a central role as the cause of ageing.
www.nature.com
September 20, 2025 at 5:20 AM
For more on the central role of DNA damage in the aging process read here our review article in Nature @natureportfolio.nature.com www.nature.com/articles/s41...
For more on how the onslaught of DNA damage that drives the aging process could be therapeutically mitigated read our article on boosting DNA repair capacities here: www.nature.com/articles/s41...
Targeting DNA damage in ageing: towards supercharging DNA repair - Nature Reviews Drug Discovery
DNA damage to the somatic genome has been identified as a major cause of ageing. This Perspective provides an overview of current understanding of the role of genome instability in the ageing process ...
www.nature.com
September 20, 2025 at 5:02 AM
For more on how the onslaught of DNA damage that drives the aging process could be therapeutically mitigated read our article on boosting DNA repair capacities here: www.nature.com/articles/s41...
For more on how molecular noise can measure biological age read our stochastic clock paper here: www.nature.com/articles/s43...
Aging clocks based on accumulating stochastic variation - Nature Aging
Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...
www.nature.com
September 20, 2025 at 5:02 AM
For more on how molecular noise can measure biological age read our stochastic clock paper here: www.nature.com/articles/s43...