bioRxiv SysBio
@biorxiv-sysbio.bsky.social
Illuminating the Role of Asymmetric Mitochondrial Fission on Beta-Cell Health https://www.biorxiv.org/content/10.1101/2025.11.25.690461v1
November 28, 2025 at 9:02 PM
Illuminating the Role of Asymmetric Mitochondrial Fission on Beta-Cell Health https://www.biorxiv.org/content/10.1101/2025.11.25.690461v1
Simulation based-inference of epidemiological and phylodynamic models via Neural Posterior Estimation https://www.biorxiv.org/content/10.1101/2025.11.25.690436v1
November 28, 2025 at 8:03 PM
Simulation based-inference of epidemiological and phylodynamic models via Neural Posterior Estimation https://www.biorxiv.org/content/10.1101/2025.11.25.690436v1
A chronic state biostimuli-responsive therapeutic model system: applications to skin tissue repair and regeneration https://www.biorxiv.org/content/10.1101/2025.11.24.690306v1
November 28, 2025 at 6:02 PM
A chronic state biostimuli-responsive therapeutic model system: applications to skin tissue repair and regeneration https://www.biorxiv.org/content/10.1101/2025.11.24.690306v1
Thermal boundaries and underlying systems biology mechanisms in two waterbloom cyanobacteria https://www.biorxiv.org/content/10.1101/2025.11.24.690146v1
November 26, 2025 at 7:02 PM
Thermal boundaries and underlying systems biology mechanisms in two waterbloom cyanobacteria https://www.biorxiv.org/content/10.1101/2025.11.24.690146v1
Stochastic Gene Expression under Sequestration: Noise Reduction and Emergent Distributions https://www.biorxiv.org/content/10.1101/2025.11.24.690157v1
November 26, 2025 at 7:02 PM
Stochastic Gene Expression under Sequestration: Noise Reduction and Emergent Distributions https://www.biorxiv.org/content/10.1101/2025.11.24.690157v1
Interconnected axes of phenotypic plasticity drive coordinated cellular behaviour and worse clinical outcomes in breast cancer https://www.biorxiv.org/content/10.1101/2025.11.23.688595v1
November 26, 2025 at 3:02 PM
Interconnected axes of phenotypic plasticity drive coordinated cellular behaviour and worse clinical outcomes in breast cancer https://www.biorxiv.org/content/10.1101/2025.11.23.688595v1
Somatic mutations impose an entropic upper bound on human lifespan https://www.biorxiv.org/content/10.1101/2025.11.23.689982v1
November 26, 2025 at 3:02 AM
Somatic mutations impose an entropic upper bound on human lifespan https://www.biorxiv.org/content/10.1101/2025.11.23.689982v1
MODY mutations in transcription factors HNF1A and HNF1B affect the production of interferon signaling proteins: evidence at the proteome level https://www.biorxiv.org/content/10.1101/2025.11.24.690114v1
November 26, 2025 at 2:02 AM
MODY mutations in transcription factors HNF1A and HNF1B affect the production of interferon signaling proteins: evidence at the proteome level https://www.biorxiv.org/content/10.1101/2025.11.24.690114v1
Metabolic imbalance limits fermentation in microbes engineered for high-titer ethanol production https://www.biorxiv.org/content/10.1101/2025.11.21.689677v1
November 24, 2025 at 4:03 PM
Metabolic imbalance limits fermentation in microbes engineered for high-titer ethanol production https://www.biorxiv.org/content/10.1101/2025.11.21.689677v1
Sex differences in gene regulation and its impact on cancer incidence https://www.biorxiv.org/content/10.1101/2025.11.21.689715v1
November 23, 2025 at 1:02 AM
Sex differences in gene regulation and its impact on cancer incidence https://www.biorxiv.org/content/10.1101/2025.11.21.689715v1
Cell Trajectory Inference based on Optimal Transport and a mechanistic stochastic gene expression model https://www.biorxiv.org/content/10.1101/2025.11.21.689689v1
November 22, 2025 at 1:04 PM
Cell Trajectory Inference based on Optimal Transport and a mechanistic stochastic gene expression model https://www.biorxiv.org/content/10.1101/2025.11.21.689689v1
Spatio-Temporal Multi-Omics Profiling of Mechanisms and Biomarkers in Inhaled Drug-Induced Lung Toxicity https://www.biorxiv.org/content/10.1101/2025.11.20.689571v1
November 21, 2025 at 10:13 PM
Spatio-Temporal Multi-Omics Profiling of Mechanisms and Biomarkers in Inhaled Drug-Induced Lung Toxicity https://www.biorxiv.org/content/10.1101/2025.11.20.689571v1
Thermo-Flux: generation and analysis of comprehensive thermodynamic-stoichiometric metabolic network models https://www.biorxiv.org/content/10.1101/2025.11.20.689566v1
November 21, 2025 at 10:13 PM
Thermo-Flux: generation and analysis of comprehensive thermodynamic-stoichiometric metabolic network models https://www.biorxiv.org/content/10.1101/2025.11.20.689566v1
The emerging role of receptor trafficking insignalosome formation and sustained long-termWnt/β-catenin signaling https://www.biorxiv.org/content/10.1101/2025.11.20.689481v1
November 21, 2025 at 2:02 AM
The emerging role of receptor trafficking insignalosome formation and sustained long-termWnt/β-catenin signaling https://www.biorxiv.org/content/10.1101/2025.11.20.689481v1
A Practical Resource for Multi-Omics Data Integration in Microbial Systems https://www.biorxiv.org/content/10.1101/2025.11.19.689359v1
November 20, 2025 at 5:02 AM
A Practical Resource for Multi-Omics Data Integration in Microbial Systems https://www.biorxiv.org/content/10.1101/2025.11.19.689359v1
Spatiotemporal-multimodal integration reveals BCG-induced skin-blood crosstalk https://www.biorxiv.org/content/10.1101/2025.11.19.689184v1
November 19, 2025 at 5:03 PM
Spatiotemporal-multimodal integration reveals BCG-induced skin-blood crosstalk https://www.biorxiv.org/content/10.1101/2025.11.19.689184v1
High-Quality Predicted Pathway Annotations Greatly Improve Pathway Enrichment Analysis of Metabolomics Datasets https://www.biorxiv.org/content/10.1101/2025.11.18.689105v1
November 19, 2025 at 5:02 PM
High-Quality Predicted Pathway Annotations Greatly Improve Pathway Enrichment Analysis of Metabolomics Datasets https://www.biorxiv.org/content/10.1101/2025.11.18.689105v1
Consensus Co-Expression Analysis Identifies A Common Set Of Co-Expressed Genes Associated With Diabetic Peripheral Neuropathy And Chemotherapy-Induced Peripheral Neuropathy https://www.biorxiv.org/content/10.1101/2025.11.18.689101v1
November 19, 2025 at 4:07 AM
Consensus Co-Expression Analysis Identifies A Common Set Of Co-Expressed Genes Associated With Diabetic Peripheral Neuropathy And Chemotherapy-Induced Peripheral Neuropathy https://www.biorxiv.org/content/10.1101/2025.11.18.689101v1
Computational Inference of Metabolic Programs: A Case Study Analyzing the Effect of BRCA1 Loss https://www.biorxiv.org/content/10.1101/2025.11.18.689039v1
November 19, 2025 at 2:03 AM
Computational Inference of Metabolic Programs: A Case Study Analyzing the Effect of BRCA1 Loss https://www.biorxiv.org/content/10.1101/2025.11.18.689039v1
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 18, 2025 at 11:03 PM
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
Optimizing Cancer Vaccinations Using a Physiologically Based Pharmacokinetic (PBPK) Model https://www.biorxiv.org/content/10.1101/2025.11.17.688910v1
November 18, 2025 at 5:03 PM
Optimizing Cancer Vaccinations Using a Physiologically Based Pharmacokinetic (PBPK) Model https://www.biorxiv.org/content/10.1101/2025.11.17.688910v1
Flux modelling analysis reveals the metabolic impact of cryptic plasmids and environmental conditions in probiotic Escherichia coli Nissle 1917 https://www.biorxiv.org/content/10.1101/2025.11.17.688048v1
November 18, 2025 at 4:09 PM
Flux modelling analysis reveals the metabolic impact of cryptic plasmids and environmental conditions in probiotic Escherichia coli Nissle 1917 https://www.biorxiv.org/content/10.1101/2025.11.17.688048v1
Autoencoder Denoising for Network-Based Spatial Transcriptomics Data with Applications for Cell Signaling Estimation https://www.biorxiv.org/content/10.1101/2025.11.17.688924v1
November 18, 2025 at 4:23 AM
Autoencoder Denoising for Network-Based Spatial Transcriptomics Data with Applications for Cell Signaling Estimation https://www.biorxiv.org/content/10.1101/2025.11.17.688924v1
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways https://www.biorxiv.org/content/10.1101/2025.11.17.687821v1
November 18, 2025 at 3:03 AM
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways https://www.biorxiv.org/content/10.1101/2025.11.17.687821v1
Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants https://www.biorxiv.org/content/10.1101/2025.11.15.688605v1
November 18, 2025 at 3:03 AM
Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants https://www.biorxiv.org/content/10.1101/2025.11.15.688605v1