bioRxiv Synthetic Biology
@biorxiv-synthbio.bsky.social
Energy-guided combinatorial co-optimization of antibody affinity and stability https://www.biorxiv.org/content/10.1101/2025.11.26.690765v1
November 27, 2025 at 4:02 AM
Energy-guided combinatorial co-optimization of antibody affinity and stability https://www.biorxiv.org/content/10.1101/2025.11.26.690765v1
Decoding Gene Responsiveness to Synthetic Chromatin Reader-Actuators with Multi-Modal Epigenomic Profiling https://www.biorxiv.org/content/10.1101/2025.11.26.690833v1
November 27, 2025 at 3:02 AM
Decoding Gene Responsiveness to Synthetic Chromatin Reader-Actuators with Multi-Modal Epigenomic Profiling https://www.biorxiv.org/content/10.1101/2025.11.26.690833v1
Tuning Yeast Glycosylation Proximal to the FLS2-flg22 Binding Interface enables Functional Yeast Surface Display under Induced ER Stress https://www.biorxiv.org/content/10.1101/2025.11.25.690463v1
November 27, 2025 at 3:02 AM
Tuning Yeast Glycosylation Proximal to the FLS2-flg22 Binding Interface enables Functional Yeast Surface Display under Induced ER Stress https://www.biorxiv.org/content/10.1101/2025.11.25.690463v1
Engineering a Bright Near-Infrared Fluorescent Protein by Screening a Comprehensive Phenotypic Landscape https://www.biorxiv.org/content/10.1101/2025.11.25.690577v1
November 26, 2025 at 12:02 PM
Engineering a Bright Near-Infrared Fluorescent Protein by Screening a Comprehensive Phenotypic Landscape https://www.biorxiv.org/content/10.1101/2025.11.25.690577v1
Synthetic niches enable co-culture bioprocessing but are prone to mutational escape https://www.biorxiv.org/content/10.1101/2025.11.24.690348v1
November 26, 2025 at 2:02 AM
Synthetic niches enable co-culture bioprocessing but are prone to mutational escape https://www.biorxiv.org/content/10.1101/2025.11.24.690348v1
A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting https://www.biorxiv.org/content/10.1101/2025.11.24.690164v1
November 25, 2025 at 3:02 AM
A programmable mRNA platform for miRNA detection via miRNA-mRNA2 triplex-mediated ribosomal frameshifting https://www.biorxiv.org/content/10.1101/2025.11.24.690164v1
Creating an energy efficient central metabolism for boosting biosynthesis without compromising cell growth of yeast https://www.biorxiv.org/content/10.1101/2025.11.22.689960v1
November 25, 2025 at 2:02 AM
Creating an energy efficient central metabolism for boosting biosynthesis without compromising cell growth of yeast https://www.biorxiv.org/content/10.1101/2025.11.22.689960v1
Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian Cells https://www.biorxiv.org/content/10.1101/2025.11.21.688514v1
November 24, 2025 at 2:03 AM
Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian Cells https://www.biorxiv.org/content/10.1101/2025.11.21.688514v1
Development and characterisation of a promoter library for Sulfolobus acidocaldarius https://www.biorxiv.org/content/10.1101/2025.11.20.689296v1
November 21, 2025 at 8:04 PM
Development and characterisation of a promoter library for Sulfolobus acidocaldarius https://www.biorxiv.org/content/10.1101/2025.11.20.689296v1
A Modular Toolkit For Theophylline-Dependent Synthetic Auxotrophs Via Riboswitch-Gated Essential Genes https://www.biorxiv.org/content/10.1101/2025.11.20.689564v1
November 21, 2025 at 10:03 AM
A Modular Toolkit For Theophylline-Dependent Synthetic Auxotrophs Via Riboswitch-Gated Essential Genes https://www.biorxiv.org/content/10.1101/2025.11.20.689564v1
STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion https://www.biorxiv.org/content/10.1101/2025.11.20.689577v1
November 21, 2025 at 8:05 AM
STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion https://www.biorxiv.org/content/10.1101/2025.11.20.689577v1
PANCS-spec-Binders: A system for rapidly discovering isoform- or epitope-specific binders https://www.biorxiv.org/content/10.1101/2025.11.19.689279v1
November 19, 2025 at 6:02 PM
PANCS-spec-Binders: A system for rapidly discovering isoform- or epitope-specific binders https://www.biorxiv.org/content/10.1101/2025.11.19.689279v1
BiosInt: Biosensor-based smart design of pathway dynamic regulation for industrial biomanufacturing https://www.biorxiv.org/content/10.1101/2025.11.17.688676v1
November 18, 2025 at 2:02 AM
BiosInt: Biosensor-based smart design of pathway dynamic regulation for industrial biomanufacturing https://www.biorxiv.org/content/10.1101/2025.11.17.688676v1
Optimization of a T7 RNA polymerase expression system for high-yield protein production in Cupriavidus necator H16 https://www.biorxiv.org/content/10.1101/2025.11.17.688765v1
November 17, 2025 at 10:02 PM
Optimization of a T7 RNA polymerase expression system for high-yield protein production in Cupriavidus necator H16 https://www.biorxiv.org/content/10.1101/2025.11.17.688765v1
pH-responsive synthetic cells for controlled protein synthesis and release https://www.biorxiv.org/content/10.1101/2025.11.16.688650v1
November 17, 2025 at 2:04 AM
pH-responsive synthetic cells for controlled protein synthesis and release https://www.biorxiv.org/content/10.1101/2025.11.16.688650v1
Reprogrammed SimCells for Antimicrobial Therapy https://www.biorxiv.org/content/10.1101/2025.11.15.688600v1
November 16, 2025 at 3:02 AM
Reprogrammed SimCells for Antimicrobial Therapy https://www.biorxiv.org/content/10.1101/2025.11.15.688600v1
Tuning a Genetic Circuit with Double Negative Feedforward Loops to Approximate Square Waves https://www.biorxiv.org/content/10.1101/2025.11.13.688370v1
November 15, 2025 at 2:02 AM
Tuning a Genetic Circuit with Double Negative Feedforward Loops to Approximate Square Waves https://www.biorxiv.org/content/10.1101/2025.11.13.688370v1
Single-component optogenetic control enables human portrait formation in cells https://www.biorxiv.org/content/10.1101/2025.11.13.688218v1
November 14, 2025 at 4:02 AM
Single-component optogenetic control enables human portrait formation in cells https://www.biorxiv.org/content/10.1101/2025.11.13.688218v1
Conjugation-mediated DNA delivery to the filamentous fungus Ustilago maydis https://www.biorxiv.org/content/10.1101/2025.11.13.688287v1
November 14, 2025 at 3:05 AM
Conjugation-mediated DNA delivery to the filamentous fungus Ustilago maydis https://www.biorxiv.org/content/10.1101/2025.11.13.688287v1
E1: Retrieval-Augmented Protein Encoder Models https://www.biorxiv.org/content/10.1101/2025.11.12.688125v1
November 14, 2025 at 3:05 AM
E1: Retrieval-Augmented Protein Encoder Models https://www.biorxiv.org/content/10.1101/2025.11.12.688125v1
Integrated microdroplet workflow for high-throughput cell-free transcription in double emulsion picoreactors https://www.biorxiv.org/content/10.1101/2025.11.13.688266v1
November 14, 2025 at 2:02 AM
Integrated microdroplet workflow for high-throughput cell-free transcription in double emulsion picoreactors https://www.biorxiv.org/content/10.1101/2025.11.13.688266v1
A funnel-type pipeline for accelerating discovery of tailored designer xylanosomes for efficient arabinoxylan valorization https://www.biorxiv.org/content/10.1101/2025.11.12.687223v1
November 13, 2025 at 4:10 AM
A funnel-type pipeline for accelerating discovery of tailored designer xylanosomes for efficient arabinoxylan valorization https://www.biorxiv.org/content/10.1101/2025.11.12.687223v1
Modular in vivo engineering of the reductive methylaspartate cycles for synthetic CO2 fixation https://www.biorxiv.org/content/10.1101/2025.11.12.688011v1
November 13, 2025 at 3:04 AM
Modular in vivo engineering of the reductive methylaspartate cycles for synthetic CO2 fixation https://www.biorxiv.org/content/10.1101/2025.11.12.688011v1
Harnessing Plasmid Crosstalk in Transcription Factor Mediated Cell-Free Biosensors https://www.biorxiv.org/content/10.1101/2025.11.11.687754v1
November 12, 2025 at 3:07 AM
Harnessing Plasmid Crosstalk in Transcription Factor Mediated Cell-Free Biosensors https://www.biorxiv.org/content/10.1101/2025.11.11.687754v1
Discovery and Functional Characterization of Salinity-Responsive Promoters in Pseudomonas putida KT2440 https://www.biorxiv.org/content/10.1101/2025.11.11.687801v1
November 12, 2025 at 3:07 AM
Discovery and Functional Characterization of Salinity-Responsive Promoters in Pseudomonas putida KT2440 https://www.biorxiv.org/content/10.1101/2025.11.11.687801v1