Bertoglio lab (FMC/UFSC)
@bertogliolab.bsky.social
Catch the latest updates on aversive learning & memory, anxiety, fear, stress, and effects of psychedelics and cannabinoids from our rodent lab in Florianopolis, Brazil, and others!
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Canabidiol, ansiedade e memórias aversivas: uma revisão das evidências pré-clínicas
| Revista Fitos
revistafitos.far.fiocruz.br
Excited to contribute to this piece on CBD effects on anxiety and fear memory, together with Marina Portes, @isabel-werle.bsky.social, Luciane Soares and Fernanda Guterres
revistafitos.far.fiocruz.br/index.php/re...
revistafitos.far.fiocruz.br/index.php/re...
Inhibition of FABP5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the limbic circuitry
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Inhibition of fatty acid binding protein 5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the...
The endocannabinoid (eCB) system modulates many biological processes, including adult neurogenesis, emotional behaviour and stress-related signaling p…
www.sciencedirect.com
November 25, 2025 at 12:14 PM
Inhibition of FABP5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the limbic circuitry
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Fear and loathing in the laboratory: An experimental comparison of pavlovian fear and disgust learning
doi.org/10.1037/emo0...
doi.org/10.1037/emo0...
APA PsycNet
doi.org
November 25, 2025 at 10:10 AM
Fear and loathing in the laboratory: An experimental comparison of pavlovian fear and disgust learning
doi.org/10.1037/emo0...
doi.org/10.1037/emo0...
DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation
doi.org/10.5498/wjp....
doi.org/10.5498/wjp....
doi.org
November 25, 2025 at 10:08 AM
DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation
doi.org/10.5498/wjp....
doi.org/10.5498/wjp....
VTA GABA neurons integrate positive and negative valence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ventral tegmental area GABA neurons integrate positive and negative valence - Nature Communications
The role of ventral tegmental area GABA neurons in behavior is unclear. Here, authors show that VTA GABA but not dopamine neurons integrate positive and negative valence to encode motivational conflic...
www.nature.com
November 25, 2025 at 10:03 AM
VTA GABA neurons integrate positive and negative valence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition - Translational Psychiatry
Translational Psychiatry - Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition
www.nature.com
November 25, 2025 at 9:56 AM
Stress-Buffer-Hypothesis: blood endocannabinoids in healthy males under standardized psychosocial stress induction and resting condition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A mouse brain atlas based on dendritic microenvironments
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A mouse brain atlas based on dendritic microenvironments - Nature Neuroscience
The authors developed a mouse brain atlas using local dendritic morphological patterns from 101,136 neurons. This representation not only improves anatomical precision but also uncovers associations b...
www.nature.com
November 25, 2025 at 9:54 AM
A mouse brain atlas based on dendritic microenvironments
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ultrastructural membrane dynamics of mouse and human cortical synapses
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Ultrastructural membrane dynamics of mouse and human cortical synapses
Eddings et al. illustrate that synaptic membrane trafficking can be studied with millisecond
resolution in resected human brain tissues using the technique “zap-and-freeze” time-resolved
electron micr...
www.cell.com
November 25, 2025 at 9:52 AM
Ultrastructural membrane dynamics of mouse and human cortical synapses
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats - Psychopharmacology
Rationale Animal models of cannabinoid self-administration are critical for advancing our understanding of the neurobiology of cannabis use and for developing medications for Cannabis Use Disorder. Us...
link.springer.com
November 25, 2025 at 9:49 AM
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Long-term dynamic profiles of cognitive kinases induced by different learning protocols
learnmem.cshlp.org/content/32/1...
learnmem.cshlp.org/content/32/1...
Long-term dynamic profiles of cognitive kinases induced by different learning protocols
Peer-reviewed scientific journal publishing basic neuroscience research in the areas of neuronal plasticity, learning and memory
learnmem.cshlp.org
November 25, 2025 at 9:47 AM
Long-term dynamic profiles of cognitive kinases induced by different learning protocols
learnmem.cshlp.org/content/32/1...
learnmem.cshlp.org/content/32/1...
Intrinsic excitability changes in amygdala neurons following observational fear conditioning in mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Intrinsic excitability changes in amygdala neurons following observational fear conditioning in mice
Observational fear conditioning (OFC) is used to study the social transmission of aversive information within a social context. In a typical experimen…
www.sciencedirect.com
November 25, 2025 at 9:46 AM
Intrinsic excitability changes in amygdala neurons following observational fear conditioning in mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Sex differences and the influence of sex hormones on fear extinction and exposure therapy across the lifespan
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Sex differences and the influence of sex hormones on fear extinction and exposure therapy across the lifespan: A systematic review of studies in rodents and humans
Fear extinction is a laboratory model that informs the mechanisms of exposure therapy for anxiety disorders. Although knowledge on fear extinction is …
www.sciencedirect.com
November 25, 2025 at 9:45 AM
Sex differences and the influence of sex hormones on fear extinction and exposure therapy across the lifespan
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa-Opioid and 5-HT2A /2C Receptor Agonists in Mice
doi.org/10.1002/npr2...
doi.org/10.1002/npr2...
Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa‐Opioid and 5‐HT2A/2C Receptor Agonists in Mice
This study developed a simple way to test new psychoactive substances (NPS) in mice. Two drugs, U50,488H and DOI caused aversive and abnormal behaviors in mice, likely linked to their hallucinogenic ...
doi.org
November 24, 2025 at 10:23 AM
Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa-Opioid and 5-HT2A /2C Receptor Agonists in Mice
doi.org/10.1002/npr2...
doi.org/10.1002/npr2...
Sex and stress govern the function and innervation of a basolateral amygdala to nucleus accumbens corticotropin releasing hormone/GABA expressing projection
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Sex and stress govern the function and innervation of a basolateral amygdala to nucleus accumbens corticotropin releasing hormone/GABA expressing projection
Motivated behaviors are executed by refined brain circuits. Early life adversity (ELA) is a risk for human affective disorders involving dysregulated reward behaviors. In mice, ELA causes anhedonia-li...
www.jneurosci.org
November 24, 2025 at 10:11 AM
Sex and stress govern the function and innervation of a basolateral amygdala to nucleus accumbens corticotropin releasing hormone/GABA expressing projection
www.jneurosci.org/content/earl...
www.jneurosci.org/content/earl...
Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning
link.springer.com/article/10.1...
link.springer.com/article/10.1...
link.springer.com
November 24, 2025 at 10:10 AM
Single prolonged stress in mice: interactions between alcohol drinking, negative affect, and fear learning
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Randomized trial of THC vs placebo to augment the effects of prolonged exposure therapy on fear extinction learning in PTSD: Study rationale and protocol
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
Redirecting
doi.org
November 23, 2025 at 10:12 AM
Randomized trial of THC vs placebo to augment the effects of prolonged exposure therapy on fear extinction learning in PTSD: Study rationale and protocol
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression: A post-hoc analysis of a randomized, waitlist-controlled trial
Cognitive difficulties within treatment-resistant unipolar and bipolar depression (TRD; TRBD) often do not improve with conventional pharmacotherapies…
www.sciencedirect.com
November 23, 2025 at 10:09 AM
Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A hyperexcited basolateral amygdala complex state determines the hippocampal structural plasticity associated with the reconsolidation of a fear memory
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A hyperexcited basolateral amygdala complex state determines the hippocampal structural plasticity associated with the reconsolidation of a fear memory
An inadequate response to traumatic experiences due to a loss of plasticity in memory processing could determine the onset of disorders such as post-t…
www.sciencedirect.com
November 23, 2025 at 10:07 AM
A hyperexcited basolateral amygdala complex state determines the hippocampal structural plasticity associated with the reconsolidation of a fear memory
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty - Molecular Psychiatry
Molecular Psychiatry - The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty
www.nature.com
November 23, 2025 at 10:06 AM
The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing - Molecular Psychiatry
Molecular Psychiatry - Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing
www.nature.com
November 23, 2025 at 10:05 AM
Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psilocybin alters visual contextual computations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psilocybin alters visual contextual computations - Nature Communications
This study finds psilocybin alters visual contextual brain processes and perception, suggesting a generic mechanism through which psychedelics influence brain function and subjective experience.
www.nature.com
November 23, 2025 at 10:04 AM
Psilocybin alters visual contextual computations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neural variability in the medial prefrontal cortex contributes to efficient adaptive behavior
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neural variability in the medial prefrontal cortex contributes to efficient adaptive behavior - Nature Communications
Neural variability is a ubiquitous brain feature, but its functional role remains unclear. Here the authors show that neural variability observed in the human prefrontal cortex through fMRI accounts f...
www.nature.com
November 23, 2025 at 10:03 AM
Neural variability in the medial prefrontal cortex contributes to efficient adaptive behavior
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states - Nature Communications
The rat prefrontal cortex has been implicated in cued food-seeking behaviour. Here, the authors identify two parallel prefrontal pathways: one that suppresses food seeking during potential threat...
www.nature.com
November 23, 2025 at 10:02 AM
Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Preclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Preclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction - Translational Psychiatry
Translational Psychiatry - Preclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction
www.nature.com
November 23, 2025 at 9:59 AM
Preclinical evidence for a novel pharmacotherapeutic approach for treating benzodiazepine addiction
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Common neural dysfunction in psychiatric disorders
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies - Translational Psychiatry
Translational Psychiatry - Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies
www.nature.com
November 23, 2025 at 9:57 AM
Common neural dysfunction in psychiatric disorders
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oligodendrocyte lineage cells dysfunction in depression
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism - Translational Psychiatry
Translational Psychiatry - Oligodendrocyte lineage cells dysfunction in depression: early life stress, adolescent vulnerability and the emerging role of lipid metabolism
www.nature.com
November 23, 2025 at 9:57 AM
Oligodendrocyte lineage cells dysfunction in depression
www.nature.com/articles/s41...
www.nature.com/articles/s41...