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At boundaries, ensembles of neurons transiently ramp up or down. These shifts are partly consistent across events of the same type - but also show trial-specific variability, creating *unique neural signatures* that could help encode episodic memories.
At boundaries, ensembles of neurons transiently ramp up or down. These shifts are partly consistent across events of the same type - but also show trial-specific variability, creating *unique neural signatures* that could help encode episodic memories.
Drift is driven by individual neurons that show diverse, slow firing patterns: some ramp, others have multiple peaks. This diversity boosts the dimensionality of the network and enables continuous, non-repeating drift.
Drift is driven by individual neurons that show diverse, slow firing patterns: some ramp, others have multiple peaks. This diversity boosts the dimensionality of the network and enables continuous, non-repeating drift.
Events unfold over different timescales. The LEC handles this by moving in *orthogonal directions* in neural state space - allowing it to track multiple timescales simultaneously without mixing them up. Downstream regions can flexibly read out what they need.
Events unfold over different timescales. The LEC handles this by moving in *orthogonal directions* in neural state space - allowing it to track multiple timescales simultaneously without mixing them up. Downstream regions can flexibly read out what they need.
When the animal encounters a meaningful change, such as a new space, object, or reward, the trajectory *abruptly speeds up*, then settles back into the baseline drift. This happens across many timescales (1 sec to several min) and doesn't require learning.
When the animal encounters a meaningful change, such as a new space, object, or reward, the trajectory *abruptly speeds up*, then settles back into the baseline drift. This happens across many timescales (1 sec to several min) and doesn't require learning.
Population activity in the lateral entorhinal cortex (LEC) slowly drifts over time, regardless of task or state, and even during sleep! It's an intrinsic feature of the network, not driven by what the animal is doing or perceiving.
Population activity in the lateral entorhinal cortex (LEC) slowly drifts over time, regardless of task or state, and even during sleep! It's an intrinsic feature of the network, not driven by what the animal is doing or perceiving.