Rebecca Gladstone
@becctococcus.bsky.social
Bioinformatician, microbial genomics, 🤓 💙 Pneumo, E. coli, capsules, AMR, vaccine evaluation and general adventure seeker living in Norway.
Pinned
Group 2 and 3 ABC-transporter dependant capsular K-loci contribute significantly to variation in the invasive potential of Escherichia coli
The major opportunistic pathogen Escherichia coli is the largest cause of antimicrobial resistance (AMR) associated infections and deaths globally. Considerable antigenic diversity has been documented...
medrxiv.org
How invasive are different E .coli capsules and how many are there? Find out here and use the group 2 and 3 database to type your own!
medrxiv.org/cgi/content/...
medrxiv.org/cgi/content/...
Reposted by Rebecca Gladstone
New preprint: we looked into production of the bacterial toxin colibactin and found that MDR E. coli from the global north have co-evolved with endemic colibactin producers, acquiring colibactin resistance genes before undergoing clonal expansions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Co-evolution between colibactin production and resistance is linked to clonal expansions in Escherichia coli
Specific strains of Escherichia coli employ the polyketide synthase island to produce a metabolite called colibactin that is implicated in colorectal tumorigenesis via its genotoxic effect on human DN...
www.biorxiv.org
November 18, 2025 at 6:41 AM
New preprint: we looked into production of the bacterial toxin colibactin and found that MDR E. coli from the global north have co-evolved with endemic colibactin producers, acquiring colibactin resistance genes before undergoing clonal expansions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rebecca Gladstone
Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...
doi.org
October 6, 2025 at 10:42 AM
Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
Reposted by Rebecca Gladstone
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes
Background Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...
www.biorxiv.org
August 29, 2025 at 2:05 PM
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
Being able to data plasmid acquisition, and to see the diversity of plasmids being gained and lost from lineages, was really eye opening! It was a pleasure to contribute my tiny bit to this huge paper and the data has so much more to give! @arredondo.bsky.social @gerrythill.bsky.social et al.
Read ‘Plasmid-driven strategies for clone success in Escherichia coli.’ From @sangerinstitute.bsky.social @uitnorgesarktiske.bsky.social, the University of Oslo, and others, in @naturecomms.bsky.social, here ⤵️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Plasmid-driven strategies for clone success in Escherichia coli - Nature Communications
Plasmids can encode multiple traits that contribute to the emergence and dissemination of their bacterial hosts. Here the authors use Nanopore long-read technology to sequence the complete genomes of ...
www.nature.com
April 3, 2025 at 11:34 AM
Being able to data plasmid acquisition, and to see the diversity of plasmids being gained and lost from lineages, was really eye opening! It was a pleasure to contribute my tiny bit to this huge paper and the data has so much more to give! @arredondo.bsky.social @gerrythill.bsky.social et al.
Reposted by Rebecca Gladstone
I'm putting together a Microbial Bioinformatics starter pack to help get everyone connected in our community. Let me know if there are any bluesky users to be added and share so that twitter refugees can tune back in to the fantastic world microbes go.bsky.app/3ezLo7e
January 10, 2025 at 9:38 AM
I'm putting together a Microbial Bioinformatics starter pack to help get everyone connected in our community. Let me know if there are any bluesky users to be added and share so that twitter refugees can tune back in to the fantastic world microbes go.bsky.app/3ezLo7e
Reposted by Rebecca Gladstone
We are hiring remote bioinformaticians at @theiagen . If you have a passion for microbial bioinformatics or public health, send your CV to [email protected] . You can be based nearly anywhere but need to be available to work US business hours.
December 5, 2024 at 2:46 PM
We are hiring remote bioinformaticians at @theiagen . If you have a passion for microbial bioinformatics or public health, send your CV to [email protected] . You can be based nearly anywhere but need to be available to work US business hours.
Reposted by Rebecca Gladstone
RTs much appreciated... would love to reach both AMR and biomath folks!
"Evolutionary accumulation modelling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance"
arxiv.org/abs/2411.00219
We think EvAM methods have some potential in AMR. 🧵
"Evolutionary accumulation modelling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance"
arxiv.org/abs/2411.00219
We think EvAM methods have some potential in AMR. 🧵
November 29, 2024 at 7:03 AM
RTs much appreciated... would love to reach both AMR and biomath folks!
"Evolutionary accumulation modelling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance"
arxiv.org/abs/2411.00219
We think EvAM methods have some potential in AMR. 🧵
"Evolutionary accumulation modelling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance"
arxiv.org/abs/2411.00219
We think EvAM methods have some potential in AMR. 🧵
Reposted by Rebecca Gladstone
Interesting and useful post from Altmetric.
TDLR:
🎉 BlueSky is an awesome place to share research.
❌ Don’t use link shorteners (unless it’s the DOI one)
✅ Keep the link in the post (don’t remove it once you have the auto-preview)
#AcademicSky #PhDSky
TDLR:
🎉 BlueSky is an awesome place to share research.
❌ Don’t use link shorteners (unless it’s the DOI one)
✅ Keep the link in the post (don’t remove it once you have the auto-preview)
#AcademicSky #PhDSky
BLUESKY MEGA-THREAD
Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:
We are now tracking research attention as it happens on Bluesky!
We have been picking up posts on the site since late Oct.
Our team is on Bluesky all day answering questions.
Let's get into it!
Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:
We are now tracking research attention as it happens on Bluesky!
We have been picking up posts on the site since late Oct.
Our team is on Bluesky all day answering questions.
Let's get into it!
December 5, 2024 at 7:42 AM
Interesting and useful post from Altmetric.
TDLR:
🎉 BlueSky is an awesome place to share research.
❌ Don’t use link shorteners (unless it’s the DOI one)
✅ Keep the link in the post (don’t remove it once you have the auto-preview)
#AcademicSky #PhDSky
TDLR:
🎉 BlueSky is an awesome place to share research.
❌ Don’t use link shorteners (unless it’s the DOI one)
✅ Keep the link in the post (don’t remove it once you have the auto-preview)
#AcademicSky #PhDSky
Reposted by Rebecca Gladstone
New paper:
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli
Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…
www.sciencedirect.com
December 5, 2024 at 9:04 AM
New paper:
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
How invasive are different E .coli capsules and how many are there? Find out here and use the group 2 and 3 database to type your own!
medrxiv.org/cgi/content/...
medrxiv.org/cgi/content/...
Group 2 and 3 ABC-transporter dependant capsular K-loci contribute significantly to variation in the invasive potential of Escherichia coli
The major opportunistic pathogen Escherichia coli is the largest cause of antimicrobial resistance (AMR) associated infections and deaths globally. Considerable antigenic diversity has been documented...
medrxiv.org
November 27, 2024 at 2:44 AM
How invasive are different E .coli capsules and how many are there? Find out here and use the group 2 and 3 database to type your own!
medrxiv.org/cgi/content/...
medrxiv.org/cgi/content/...