Brilliant work led by @luisherhuertas.bsky.social

— thanks to @stowersinstitute.bsky.social and @cabd-upo-csic.bsky.social

At the same time, we made thousands of synonymous mutations in endogenous yeast genes and measured their growth. We used careful statistics and controls. Only 3%, 204 of 6874, had a fitness effect! This goes against a controversial recent result that most synonymous mutations had fitness effects.