Baylink Lab
@baylinklab.bsky.social
🦠Enthusiastic microthanatologists (i.e. the study of how to kill microbes) & lovers of redox biology and bacterial chemotaxis🧫
Washington State University - Esch LEAD Professor - Inclusion of Rural Individuals in Science (IRIS)
www.baylink-lab.com
Washington State University - Esch LEAD Professor - Inclusion of Rural Individuals in Science (IRIS)
www.baylink-lab.com
You can also stop reviewing for that journal and not publish there yourself.
Of course there will be real scientific disagreements that an editor will need to make a judgement call for the appropriate course of action. Yours doesn’t sound like such a case.
Of course there will be real scientific disagreements that an editor will need to make a judgement call for the appropriate course of action. Yours doesn’t sound like such a case.
September 28, 2025 at 9:28 PM
You can also stop reviewing for that journal and not publish there yourself.
Of course there will be real scientific disagreements that an editor will need to make a judgement call for the appropriate course of action. Yours doesn’t sound like such a case.
Of course there will be real scientific disagreements that an editor will need to make a judgement call for the appropriate course of action. Yours doesn’t sound like such a case.
Good question. It is a cycle. Ticks feed on an infected animal and acquire the bacteria (from ingesting the blood), and then pass it on to other animals/humans.
September 25, 2025 at 12:36 AM
Good question. It is a cycle. Ticks feed on an infected animal and acquire the bacteria (from ingesting the blood), and then pass it on to other animals/humans.
Absolutely! In general, motile bacteria can literally swim circles around phagocytes...
September 24, 2025 at 5:54 PM
Absolutely! In general, motile bacteria can literally swim circles around phagocytes...
I am sure it is complicated and situation dependent, but this study covers some of those topics:
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation
Author summary Lyme disease, caused by the spirochete Borrelia burgdorferi (Bb), is a long-term infection whose inflammatory manifestations are primarily due to an exuberant immune response to the pat...
journals.plos.org
September 24, 2025 at 2:19 PM
I am sure it is complicated and situation dependent, but this study covers some of those topics:
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Unfortunately (as I am sure you know) many people are affected - a great reason for us to keep investigating potential new and more effective treatments.
September 23, 2025 at 11:50 PM
Unfortunately (as I am sure you know) many people are affected - a great reason for us to keep investigating potential new and more effective treatments.
The video captures frames every 1 s over a few minutes. The attached image shows a 'max' projection over 30 minutes that illustrates the path of their movement similar to a time-lapse.
September 23, 2025 at 11:42 PM
The video captures frames every 1 s over a few minutes. The attached image shows a 'max' projection over 30 minutes that illustrates the path of their movement similar to a time-lapse.
Reposted by Baylink Lab
Link to new article in Nature:
Extreme armour in the world’s oldest ankylosaur
🧪🦖🦕
www.nature.com/articles/s41...
Extreme armour in the world’s oldest ankylosaur
🧪🦖🦕
www.nature.com/articles/s41...
Extreme armour in the world’s oldest ankylosaur - Nature
The ankylosaurian dinosaur Spicomellus afer possessed a tail weapon and uniquely elaborate dermal armour.
www.nature.com
August 28, 2025 at 5:10 AM
Link to new article in Nature:
Extreme armour in the world’s oldest ankylosaur
🧪🦖🦕
www.nature.com/articles/s41...
Extreme armour in the world’s oldest ankylosaur
🧪🦖🦕
www.nature.com/articles/s41...
I’m Arden, and my lab is trying to develop new antibiotics to treat bacterial infections!
The lab is based at Washington State University in Pullman - Go Cougs!
The lab is based at Washington State University in Pullman - Go Cougs!
August 21, 2025 at 3:07 AM
I’m Arden, and my lab is trying to develop new antibiotics to treat bacterial infections!
The lab is based at Washington State University in Pullman - Go Cougs!
The lab is based at Washington State University in Pullman - Go Cougs!
Lots of new-to-protein-structure folks are using AF3, which is great! However, non-experts might be inclined to feed AF3 incorrect information, such as modeling a monomer when the biologically-relevant state is a dimer. We found this can decrease model accuracy due to missing tertiary interactions.
August 12, 2025 at 4:35 PM
Lots of new-to-protein-structure folks are using AF3, which is great! However, non-experts might be inclined to feed AF3 incorrect information, such as modeling a monomer when the biologically-relevant state is a dimer. We found this can decrease model accuracy due to missing tertiary interactions.
Antibiotic resistance and immunogenicity are impacted by small variations in protein sequence but it isn't feasible to experimentally determine structures for the many thousands of variants that exist in nature. In this particular system AF3 generated extremely accurate models for variant sites.
August 12, 2025 at 4:30 PM
Antibiotic resistance and immunogenicity are impacted by small variations in protein sequence but it isn't feasible to experimentally determine structures for the many thousands of variants that exist in nature. In this particular system AF3 generated extremely accurate models for variant sites.
We had a crystal structure of Helicobacter catalase collecting dust, so decided to turn it into an Alphafold test case for modeling natural protein variants, i.e. proteins with small sequence differences.
Study published here: journals.asm.org/eprint/J45UR...
Study published here: journals.asm.org/eprint/J45UR...
AlphaFold 3 accurately models natural variants of Helicobacter pylori catalase KatA | Microbiology Spectrum
Experimental structure determination is rarely performed for natural protein variants
possessing only minor amino acid differences from published structures, even though
small substitutions can signif...
journals.asm.org
August 12, 2025 at 4:25 PM
We had a crystal structure of Helicobacter catalase collecting dust, so decided to turn it into an Alphafold test case for modeling natural protein variants, i.e. proteins with small sequence differences.
Study published here: journals.asm.org/eprint/J45UR...
Study published here: journals.asm.org/eprint/J45UR...
Well now Im learning new things about indole! When we work with the bottle in dry format it is a bit pungent but not so bad as 💩
July 15, 2025 at 10:52 PM
Well now Im learning new things about indole! When we work with the bottle in dry format it is a bit pungent but not so bad as 💩
Some behind-the-scenes insight on the research for non-experts. And FYI, the 'stinky' indole for poo we studied here is actually a major ingredient in lots of perfumes. Turns out it smells better at low concentrations!
news.wsu.edu/press-releas...
news.wsu.edu/press-releas...
Disease-causing bacteria can deal with stink as long as they get a meal
New WSU research shows gut pathogens like Salmonella will brave a toxic chemical to reach nutrients, offering insights for treating infections.
news.wsu.edu
July 15, 2025 at 8:58 PM
Some behind-the-scenes insight on the research for non-experts. And FYI, the 'stinky' indole for poo we studied here is actually a major ingredient in lots of perfumes. Turns out it smells better at low concentrations!
news.wsu.edu/press-releas...
news.wsu.edu/press-releas...