Bart Deplancke
@bartdeplancke.bsky.social
Professor in Systems Biology & Genetics @EPFL, opinions my own; Single Cell Omics / Gene Regulation / Transcription Factor / Stem Cells / Regulatory Variation / ML / Imaging / Adipose Biology / Microfluidics
https://www.epfl.ch/labs/deplanckelab
https://www.epfl.ch/labs/deplanckelab
🧵2/ Across 384 TFs and ~40,000 cells, we found:
– Nonlinear, dose-sensitive reprogramming responses
– TFs triggering different fates at low vs high dose
– Same dose, different outcome = hidden complexity
– TF pairs flipping between synergy & antagonism based on dose ratio
– Nonlinear, dose-sensitive reprogramming responses
– TFs triggering different fates at low vs high dose
– Same dose, different outcome = hidden complexity
– TF pairs flipping between synergy & antagonism based on dose ratio
October 6, 2025 at 6:57 AM
🧵2/ Across 384 TFs and ~40,000 cells, we found:
– Nonlinear, dose-sensitive reprogramming responses
– TFs triggering different fates at low vs high dose
– Same dose, different outcome = hidden complexity
– TF pairs flipping between synergy & antagonism based on dose ratio
– Nonlinear, dose-sensitive reprogramming responses
– TFs triggering different fates at low vs high dose
– Same dose, different outcome = hidden complexity
– TF pairs flipping between synergy & antagonism based on dose ratio
Fantastic work by Camille Lambert, Guido van Mierlo, Orane Guillaume-Gentil and Johannes Bues. For a related review on 'The evolution of DNA sequencing with microfluidics', pls also see: www.nature.com/articles/s41...
The evolution of DNA sequencing with microfluidics - Nature Reviews Genetics
The adoption of microfluidics was fundamental to the development of cost-effective, high-throughput DNA sequencing. As the field progresses towards multi-omics, Lambert et al. reflect on the key conce...
www.nature.com
June 2, 2025 at 9:43 AM
Fantastic work by Camille Lambert, Guido van Mierlo, Orane Guillaume-Gentil and Johannes Bues. For a related review on 'The evolution of DNA sequencing with microfluidics', pls also see: www.nature.com/articles/s41...
Sounds very exciting, very much looking forward!
March 2, 2025 at 2:08 PM
Sounds very exciting, very much looking forward!
Happy to be part of the feed Erik, thanks for the initiative. scholar.google.ch/citations?us...
Bart Deplancke
Professor in Systems Biology and Genetics at EPFL - Cited by 18,422 - genetics - transcription - systems biology - single cell
scholar.google.ch
January 24, 2025 at 6:44 AM
Happy to be part of the feed Erik, thanks for the initiative. scholar.google.ch/citations?us...
Not that I know of, but it is for sure a good idea. Someone simply needs to start it! 💪
January 11, 2025 at 5:44 PM
Not that I know of, but it is for sure a good idea. Someone simply needs to start it! 💪
Fully agree with Carlos! Having peers at a similar career stage has been invaluable—building lasting relationships, inspiring great science, and acting as soundboards for new ideas. These connections still help navigate the daily grind of being a PI. So excited to see the JEDI Phoenix rise again! 🚀✨
January 11, 2025 at 9:37 AM
Fully agree with Carlos! Having peers at a similar career stage has been invaluable—building lasting relationships, inspiring great science, and acting as soundboards for new ideas. These connections still help navigate the daily grind of being a PI. So excited to see the JEDI Phoenix rise again! 🚀✨