Barbara Clough
@babs-c.bsky.social
Research Fellow in Chen Lab UoB, enjoying host-pathogen interaction, bacterial lipid remodelling, cell biology and imaging.
Reposted by Barbara Clough
Exciting work from neighbor Jörn Coers at Duke identifying a new class of host defense GTPases. Out of a genetic screen they identify the human Giant GTPase GVIN1 (previously annotated as a human pseudogene) in coatomer-based restriction of Burkholderia motility. 1808 aas long!
Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis
Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activated by the cytokine interferon-ga...
www.biorxiv.org
April 14, 2025 at 4:14 PM
Exciting work from neighbor Jörn Coers at Duke identifying a new class of host defense GTPases. Out of a genetic screen they identify the human Giant GTPase GVIN1 (previously annotated as a human pseudogene) in coatomer-based restriction of Burkholderia motility. 1808 aas long!
Reposted by Barbara Clough
Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions!
👉 go.nature.com/43k1a0H
👉 go.nature.com/43k1a0H
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 6:36 AM
Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions!
👉 go.nature.com/43k1a0H
👉 go.nature.com/43k1a0H
Reposted by Barbara Clough
Delighted to share our last pre print -this one close to my heart- We set to define the rules of lipid A associated with virulence by interrogating the genus Yersinia. www.biorxiv.org/content/10.1...
Interrogating the genus Yersinia to define the rules of lipopolysaccharide lipid A structure associated with pathogenicity.
Pathogen recognition by the immune system relies on germline-encoded pathogen recognition receptors which identify conserved pathogen-associated molecular patterns (PAMPs) such as the lipid A section ...
www.biorxiv.org
March 4, 2025 at 9:19 AM
Delighted to share our last pre print -this one close to my heart- We set to define the rules of lipid A associated with virulence by interrogating the genus Yersinia. www.biorxiv.org/content/10.1...
Reposted by Barbara Clough
I'm excited to share our latest research on Enterobacter's infection biology in the Journal of Infectious Diseases (tinyurl.com/bcxmn8nc), showing that antimicrobial-resistant Enterobacter species can persist in human macrophages without replication, causing minimal cytotoxicity.
Clinical isolates of antimicrobial resistant Enterobacter species can persist in human macrophages without replication and overt cellular cytotoxicity
This study underscores the capacity of antibiotic-resistant Enterobacter clinical isolates to persist in macrophages without significantly alerting the inn
tinyurl.com
March 3, 2025 at 3:22 PM
I'm excited to share our latest research on Enterobacter's infection biology in the Journal of Infectious Diseases (tinyurl.com/bcxmn8nc), showing that antimicrobial-resistant Enterobacter species can persist in human macrophages without replication, causing minimal cytotoxicity.
Reposted by Barbara Clough
🎉 Our March issue is live! Read it here:
nature.com/nrmicro/volumes/23/issues/3
🌍 Human impacts on subsurface microbial communities
🦠 Akkermansia muciniphila
🦟 Next-generation treatment options for P. falciparum malaria
🔍 Examining the healthy human microbiome concept
nature.com/nrmicro/volumes/23/issues/3
🌍 Human impacts on subsurface microbial communities
🦠 Akkermansia muciniphila
🦟 Next-generation treatment options for P. falciparum malaria
🔍 Examining the healthy human microbiome concept
February 20, 2025 at 3:53 AM
🎉 Our March issue is live! Read it here:
nature.com/nrmicro/volumes/23/issues/3
🌍 Human impacts on subsurface microbial communities
🦠 Akkermansia muciniphila
🦟 Next-generation treatment options for P. falciparum malaria
🔍 Examining the healthy human microbiome concept
nature.com/nrmicro/volumes/23/issues/3
🌍 Human impacts on subsurface microbial communities
🦠 Akkermansia muciniphila
🦟 Next-generation treatment options for P. falciparum malaria
🔍 Examining the healthy human microbiome concept
Reposted by Barbara Clough
Host and pathogen aficionados:
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Cell biology of host-pathogen interactions
Microbial infections lead to drastic changes in the architecture and metabolism of the host cell. The inaugural FEBS EMBO Cell Biology of Host-Pathogen Interaction Advanced Course explores the mechan…
meetings.embo.org
February 23, 2025 at 12:17 AM
Host and pathogen aficionados:
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Reposted by Barbara Clough
Are you interested in bacterial pathogen physiology 🧫 and their interactions with our tissues during infections?
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
February 21, 2025 at 9:18 PM
Are you interested in bacterial pathogen physiology 🧫 and their interactions with our tissues during infections?
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
Reposted by Barbara Clough
Our spring round of PhD recruitment is now open!
We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science.
Find out more and apply by midday, 19 March:
www.crick.ac.uk/careers-stud...
We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science.
Find out more and apply by midday, 19 March:
www.crick.ac.uk/careers-stud...
PhD student recruitment
2025 PhD recruitment is now open!
www.crick.ac.uk
February 20, 2025 at 4:48 PM
Our spring round of PhD recruitment is now open!
We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science.
Find out more and apply by midday, 19 March:
www.crick.ac.uk/careers-stud...
We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science.
Find out more and apply by midday, 19 March:
www.crick.ac.uk/careers-stud...
Reposted by Barbara Clough
Researchers have isolated an ultrasmall bacterium belonging to a large phylogenetic group that includes various lineages of uncultivated bacteria — the CPR. Read the press release on the research, published in #IJSEM, here https://microb.io/4hBcCt6 🔬
A novel bacteria parasitizing archaea
13 February 2025
microb.io
February 14, 2025 at 3:00 PM
Researchers have isolated an ultrasmall bacterium belonging to a large phylogenetic group that includes various lineages of uncultivated bacteria — the CPR. Read the press release on the research, published in #IJSEM, here https://microb.io/4hBcCt6 🔬