Aubry K. Miller
@aubrykmiller.bsky.social
Group leader at the DKFZ. Using the power of organic synthesis in medicinal chemistry and chemical biology. https://www.dkfz.de/en/cancer-drug-development
Reposted by Aubry K. Miller
💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback."
Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)
Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)
When is a Monomer not a Monomer? The Top Three Ways Your Favorite Fluorescent Protein Oligomerizes in Cells
Many commonly used fluorescent proteins form dimers producing artifacts in a variety of experimental settings. Learn how to avoid these artifacts.
blog.addgene.org
July 29, 2025 at 4:04 PM
💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback."
Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)
Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)
I can't believe I missed @dereklowe.bsky.social commenting on our @natchem.nature.com a month ago at "In the Pipeline". I've dreamt for many years that Derek would choose to highlight work coming out of the lab. That feels like a real stamp of approval. Thanks, Derek! www.science.org/content/blog...
Proton Pump Inhibitors Do More Than You Think
www.science.org
May 26, 2025 at 2:05 PM
I can't believe I missed @dereklowe.bsky.social commenting on our @natchem.nature.com a month ago at "In the Pipeline". I've dreamt for many years that Derek would choose to highlight work coming out of the lab. That feels like a real stamp of approval. Thanks, Derek! www.science.org/content/blog...
Reposted by Aubry K. Miller
Our Synthetic Genomics Center "SynGen" is looking for a coordinator, located at @kit.edu Karlsruhe, but coordinating also the U Heidelberg and U Mainz sites.
We are hoping to fill this vacancy ASAP.
For further info, please visit:
www.syn-gen.de/en
www.pse.kit.edu/english/karr...
Please share 🙏
We are hoping to fill this vacancy ASAP.
For further info, please visit:
www.syn-gen.de/en
www.pse.kit.edu/english/karr...
Please share 🙏
April 10, 2025 at 7:52 AM
Our Synthetic Genomics Center "SynGen" is looking for a coordinator, located at @kit.edu Karlsruhe, but coordinating also the U Heidelberg and U Mainz sites.
We are hoping to fill this vacancy ASAP.
For further info, please visit:
www.syn-gen.de/en
www.pse.kit.edu/english/karr...
Please share 🙏
We are hoping to fill this vacancy ASAP.
For further info, please visit:
www.syn-gen.de/en
www.pse.kit.edu/english/karr...
Please share 🙏
The most recent roadmap problem from our Synthesis Club is up on our shiny new website. This quiz highlights the synthesis of clionastatin B from the group of Jinghuan Gui. www.dkfz.de/en/cancer-dr...
February 24, 2025 at 12:51 PM
The most recent roadmap problem from our Synthesis Club is up on our shiny new website. This quiz highlights the synthesis of clionastatin B from the group of Jinghuan Gui. www.dkfz.de/en/cancer-dr...
Check out our paper on proton pump inhibitor activation (PPI) in cells in Nature Chemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@redoxdkfz.bsky.social). More collabs between our groups to come! doi.org/10.1038/s415...
Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres - Nature Chemistry
Proton pump inhibitors (PPIs) are prodrugs that are activated by protonation in the highly acidic environment of the stomach lining. Now, coordination of PPIs to protein-bound zinc ions is revealed as...
www.nature.com
February 20, 2025 at 12:22 PM
Check out our paper on proton pump inhibitor activation (PPI) in cells in Nature Chemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@redoxdkfz.bsky.social). More collabs between our groups to come! doi.org/10.1038/s415...
Congrats to Niki and the whole team for this new collaboration with Sanofi.
www.linkedin.com/posts/dkfz-i...
www.linkedin.com/posts/dkfz-i...
DKFZ Innovation Management on LinkedIn: #collaboration #innovation #cancerresearch #academicindustrypartnership…
Targeting hallmarks of cancer
👏 We are pleased to announce that the project of Dr Nikolas Gunkel of the DKFZ German Cancer Research Center has been awarded a…
www.linkedin.com
February 20, 2025 at 9:04 AM
Congrats to Niki and the whole team for this new collaboration with Sanofi.
www.linkedin.com/posts/dkfz-i...
www.linkedin.com/posts/dkfz-i...
Great opportunity to work with an excellent young group leader.
Did you recently complete a ChemBio/MedChem PhD (non-UK) and are looking for the next challenge? I am seeking a prospective applicant for a Newton Fellowship with an exciting project in targeted protein dephosphorylation! Please reach out to [email protected]
royalsociety.org/grants/newto...
royalsociety.org/grants/newto...
royalsociety.org
February 17, 2025 at 10:02 AM
Great opportunity to work with an excellent young group leader.
Reposted by Aubry K. Miller
From Dorothea Fiedler's lab: Protein polyphosphorylation as a new post-translational modification www.biorxiv.org/content/10.1...
January 23, 2025 at 8:11 AM
From Dorothea Fiedler's lab: Protein polyphosphorylation as a new post-translational modification www.biorxiv.org/content/10.1...
This week’s Synthesis Club quiz featured a total synthesis that one of our recent Master’s students contributed to as an intern in the US. Anyone recognize this beauty?
January 15, 2025 at 10:19 AM
This week’s Synthesis Club quiz featured a total synthesis that one of our recent Master’s students contributed to as an intern in the US. Anyone recognize this beauty?
I had no idea Rodney Mullen, the Godfather of skateboarding, had studied Chemical Engineering. Thanks, Rodney, for putting two of my favorite things together on one slide. youtu.be/2c3aXbwM8L0?...
January 13, 2025 at 7:55 PM
I had no idea Rodney Mullen, the Godfather of skateboarding, had studied Chemical Engineering. Thanks, Rodney, for putting two of my favorite things together on one slide. youtu.be/2c3aXbwM8L0?...
Starting what will hopefully become a regular feature here…our disconnection analysis of a natural product total synthesis from our biweekly Synthesis Club meetings. Anyone recognize this recent beauty? #chemsky
November 19, 2024 at 8:10 AM
Starting what will hopefully become a regular feature here…our disconnection analysis of a natural product total synthesis from our biweekly Synthesis Club meetings. Anyone recognize this recent beauty? #chemsky
Congratulations to former PhD student Raphael Steimbach for winning the EFMC-Young Scientists Network PhD prize (www.efmc.info/ysn-phd-prize). Come see his lecture in Rome at #EFMC-ISMC in September. Congratulations Raphael!
May 13, 2024 at 8:56 AM
Congratulations to former PhD student Raphael Steimbach for winning the EFMC-Young Scientists Network PhD prize (www.efmc.info/ysn-phd-prize). Come see his lecture in Rome at #EFMC-ISMC in September. Congratulations Raphael!