thetranscendedman
@atranscendedman.bsky.social
Transparent to the transcendent.
Wrote a book on Long Covid. - https://jondouglas.dev/longhaul/
Extraordinary claims require extraordinary evidence. - Sagan
Wrote a book on Long Covid. - https://jondouglas.dev/longhaul/
Extraordinary claims require extraordinary evidence. - Sagan
Thanksgiving. That special day when I remind my family of humanity's greatest, most ignored doom… and they remind me why I’m not invited to speak at dinner anymore.
November 26, 2025 at 3:14 PM
Thanksgiving. That special day when I remind my family of humanity's greatest, most ignored doom… and they remind me why I’m not invited to speak at dinner anymore.
"The fact of antiviral medication helping with Alzheimer's would be stunning"
November 26, 2025 at 2:45 PM
"The fact of antiviral medication helping with Alzheimer's would be stunning"
University of Tübingen researchers found SARS-CoV-2 proteins in human hair follicles from 2 of 3 donors.
These proteins appeared in stem cell zones and were linked to stress signals, offering a possible cause for COVID-related hair loss.
www.nature.com/articles/s41...
These proteins appeared in stem cell zones and were linked to stress signals, offering a possible cause for COVID-related hair loss.
www.nature.com/articles/s41...
Ex vivo detection of SARS CoV 2 spike protein in human hair follicles and potential link to telogen effluvium - Scientific Reports
Scientific Reports - Ex vivo detection of SARS CoV 2 spike protein in human hair follicles and potential link to telogen effluvium
www.nature.com
November 26, 2025 at 2:26 PM
University of Tübingen researchers found SARS-CoV-2 proteins in human hair follicles from 2 of 3 donors.
These proteins appeared in stem cell zones and were linked to stress signals, offering a possible cause for COVID-related hair loss.
www.nature.com/articles/s41...
These proteins appeared in stem cell zones and were linked to stress signals, offering a possible cause for COVID-related hair loss.
www.nature.com/articles/s41...
Keio University studied 1034 COVID-19 patients and used CT scans to group them by lung damage and fat buildup.
Patients with high visceral fat and pneumonia had the worst breathing problems.
www.nature.com/articles/s41...
Patients with high visceral fat and pneumonia had the worst breathing problems.
www.nature.com/articles/s41...
CT-based phenotyping of COVID-19: cluster analysis of pulmonary and extrapulmonary imaging markers from a multicentre retrospective cohort study - Scientific Reports
Scientific Reports - CT-based phenotyping of COVID-19: cluster analysis of pulmonary and extrapulmonary imaging markers from a multicentre retrospective cohort study
www.nature.com
November 26, 2025 at 2:25 PM
Keio University studied 1034 COVID-19 patients and used CT scans to group them by lung damage and fat buildup.
Patients with high visceral fat and pneumonia had the worst breathing problems.
www.nature.com/articles/s41...
Patients with high visceral fat and pneumonia had the worst breathing problems.
www.nature.com/articles/s41...
From Asan Medical Center, studying 278 people about a year after mild COVID, researchers found those with long COVID-related cognitive issues had signs of brain injury, iron buildup, and neurodegenerative changes not seen in other patients.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19 - Nature Communications
Post-acute sequelae of SARS-CoV-2 (PASC) have been linked to brain alterations, but association with cognitive problems are not well understood. Here, the authors analyze blood proteins and brain MRI ...
www.nature.com
November 26, 2025 at 2:24 PM
From Asan Medical Center, studying 278 people about a year after mild COVID, researchers found those with long COVID-related cognitive issues had signs of brain injury, iron buildup, and neurodegenerative changes not seen in other patients.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Charité University Hospital in Berlin reports that CAR-T-cell therapy has sent people with lupus and rheumatoid arthritis into remission.
They lose autoantibodies and symptoms disappear.
Researchers call it something totally new.
www.nature.com/articles/d41...
They lose autoantibodies and symptoms disappear.
Researchers call it something totally new.
www.nature.com/articles/d41...
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.
www.nature.com
November 26, 2025 at 2:17 PM
Charité University Hospital in Berlin reports that CAR-T-cell therapy has sent people with lupus and rheumatoid arthritis into remission.
They lose autoantibodies and symptoms disappear.
Researchers call it something totally new.
www.nature.com/articles/d41...
They lose autoantibodies and symptoms disappear.
Researchers call it something totally new.
www.nature.com/articles/d41...
Hadassah Medical Center tracked 208 ICU patients and found at least 30% had CMV reactivation.
COVID-19 patients faced nearly double the risk, with 12% developing CMV disease, linked to steroids, low lymphocytes, and higher death rates.
www.nature.com/articles/s41...
COVID-19 patients faced nearly double the risk, with 12% developing CMV disease, linked to steroids, low lymphocytes, and higher death rates.
www.nature.com/articles/s41...
Risk factors associated with cytomegalovirus reactivation and disease in critically-ill COVID-19 and non-COVID-19 patients, concomitantly admitted to intensive care - Scientific Reports
Scientific Reports - Risk factors associated with cytomegalovirus reactivation and disease in critically-ill COVID-19 and non-COVID-19 patients, concomitantly admitted to intensive care
www.nature.com
November 26, 2025 at 1:28 AM
Hadassah Medical Center tracked 208 ICU patients and found at least 30% had CMV reactivation.
COVID-19 patients faced nearly double the risk, with 12% developing CMV disease, linked to steroids, low lymphocytes, and higher death rates.
www.nature.com/articles/s41...
COVID-19 patients faced nearly double the risk, with 12% developing CMV disease, linked to steroids, low lymphocytes, and higher death rates.
www.nature.com/articles/s41...
Researchers from Nanyang Technological University reviewed how gut viruses, fungi, and archaea affect obesity.
These non-bacterial microbes can reshape metabolism and weight by interacting with gut bacteria and influencing nutrient absorption.
www.sciencedirect.com/science/arti...
These non-bacterial microbes can reshape metabolism and weight by interacting with gut bacteria and influencing nutrient absorption.
www.sciencedirect.com/science/arti...
The Role of the Gut Non-Bacterial Microbiome (Virome, Mycobiome, Archaeome) and its Impact on Obesity
The epidemic of obesity and metabolic syndrome is a major public health concern internationally. There is increasing knowledge and research in areas o…
www.sciencedirect.com
November 26, 2025 at 12:50 AM
Researchers from Nanyang Technological University reviewed how gut viruses, fungi, and archaea affect obesity.
These non-bacterial microbes can reshape metabolism and weight by interacting with gut bacteria and influencing nutrient absorption.
www.sciencedirect.com/science/arti...
These non-bacterial microbes can reshape metabolism and weight by interacting with gut bacteria and influencing nutrient absorption.
www.sciencedirect.com/science/arti...
Researchers at the Institute for Research in Biomedicine studied tattoo ink in mice and found it builds up in lymph nodes, triggers long-lasting inflammation, and alters how the body responds to vaccines like COVID-19 and flu.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 25, 2025 at 7:41 PM
Researchers at the Institute for Research in Biomedicine studied tattoo ink in mice and found it builds up in lymph nodes, triggers long-lasting inflammation, and alters how the body responds to vaccines like COVID-19 and flu.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Galicia Sur Health Institute researchers studied 394 patients and found that an AI model using data from the first 72 hours of COVID-19 hospitalization could predict long COVID risk.
Low hemoglobin and oxygen levels were key warning signs.
www.sciencedirect.com/science/arti...
Low hemoglobin and oxygen levels were key warning signs.
www.sciencedirect.com/science/arti...
Artificial intelligence-based identification of key risk factors for long COVID from early clinical data
Long COVID, a complex condition characterized by persistent symptoms following SARS-CoV-2 infection, has become a significant public health concern. E…
www.sciencedirect.com
November 25, 2025 at 3:34 PM
Galicia Sur Health Institute researchers studied 394 patients and found that an AI model using data from the first 72 hours of COVID-19 hospitalization could predict long COVID risk.
Low hemoglobin and oxygen levels were key warning signs.
www.sciencedirect.com/science/arti...
Low hemoglobin and oxygen levels were key warning signs.
www.sciencedirect.com/science/arti...
Researchers from Guangzhou University reviewed evidence linking viruses to gut cancers.
At least 25% of people with HIV develop cancer, with higher risk across the GI tract.
SARS-CoV-2 may also raise long-term risk, but evidence is still emerging.
www.sciencedirect.com/science/arti...
At least 25% of people with HIV develop cancer, with higher risk across the GI tract.
SARS-CoV-2 may also raise long-term risk, but evidence is still emerging.
www.sciencedirect.com/science/arti...
Viruses in gastrointestinal cancers: Molecular pathogenesis, oncogenic mechanisms, and translational perspectives
Viral pathogens are one of the most significant causes of human carcinogenesis, contributing to up to 15–20 % of worldwide cancers. The gastrointestin…
www.sciencedirect.com
November 25, 2025 at 3:33 PM
Researchers from Guangzhou University reviewed evidence linking viruses to gut cancers.
At least 25% of people with HIV develop cancer, with higher risk across the GI tract.
SARS-CoV-2 may also raise long-term risk, but evidence is still emerging.
www.sciencedirect.com/science/arti...
At least 25% of people with HIV develop cancer, with higher risk across the GI tract.
SARS-CoV-2 may also raise long-term risk, but evidence is still emerging.
www.sciencedirect.com/science/arti...
From the National Institute of Ayurveda and Naidu Hospital, trials in 150 participants showed that an herbal formulation called HF-2 boosted T-cell immunity in healthy adults and sped up recovery from mild to moderate COVID-19 without adverse effects.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Immunomodulatory and antiviral properties of herbal formulation: Evidence from clinical trials in healthy volunteers, COVID-19 patients and molecular docking studies
This study aimed to evaluate the immunomodulatory and antiviral potential of herbal formulation through clinical trials in healthy volunteers and COVI…
www.sciencedirect.com
November 25, 2025 at 3:32 PM
From the National Institute of Ayurveda and Naidu Hospital, trials in 150 participants showed that an herbal formulation called HF-2 boosted T-cell immunity in healthy adults and sped up recovery from mild to moderate COVID-19 without adverse effects.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
COMET-PEAK trial with 324 adults found that intramuscular sotrovimab was as effective as intravenous infusion in reducing viral load in mild COVID-19.
Both doses were safe and well tolerated.
Viral load may not predict disease progression.
link.springer.com/article/10.1...
Both doses were safe and well tolerated.
Viral load may not predict disease progression.
link.springer.com/article/10.1...
Safety, Tolerability, Pharmacokinetics, and Viral Pharmacodynamics of the Monoclonal Antibody Sotrovimab Administered via Intramuscular Injection in Participants with Early, Mild-to-Moderate COVID-19:...
Background and Objectives New coronavirus disease 2019 (COVID-19) therapeutics, including intramuscular (IM) formulations, may increase patient access. In COMET-TAIL, sotrovimab 500 mg IM was non-infe...
link.springer.com
November 25, 2025 at 3:00 PM
COMET-PEAK trial with 324 adults found that intramuscular sotrovimab was as effective as intravenous infusion in reducing viral load in mild COVID-19.
Both doses were safe and well tolerated.
Viral load may not predict disease progression.
link.springer.com/article/10.1...
Both doses were safe and well tolerated.
Viral load may not predict disease progression.
link.springer.com/article/10.1...
Researchers tested 75 marine actinomycete strains and found that at least 36% blocked a key SARS-CoV-2 enzyme by over 90%.
One compound, streptocarbazole C, showed strong binding to the viral protease with low predicted toxicity.
www.nature.com/articles/s41...
One compound, streptocarbazole C, showed strong binding to the viral protease with low predicted toxicity.
www.nature.com/articles/s41...
Identification of SARS-CoV-2 3CLpro inhibitors from marine actinomycetes through integrated phylogeny-based metabolomics with functional screening and bioinformatic analysis - Scientific Reports
Scientific Reports - Identification of SARS-CoV-2 3CLpro inhibitors from marine actinomycetes through integrated phylogeny-based metabolomics with functional screening and bioinformatic analysis
www.nature.com
November 25, 2025 at 2:59 PM
Researchers tested 75 marine actinomycete strains and found that at least 36% blocked a key SARS-CoV-2 enzyme by over 90%.
One compound, streptocarbazole C, showed strong binding to the viral protease with low predicted toxicity.
www.nature.com/articles/s41...
One compound, streptocarbazole C, showed strong binding to the viral protease with low predicted toxicity.
www.nature.com/articles/s41...
Beijing Chao-Yang Hospital followed 347 patients with interstitial lung disease for 2 years and found that those with multiple COVID-19 infections had a 61% rate of disease worsening compared to 42% with a single infection.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
SARS-CoV-2 reinfection in interstitial lung disease patients and its association with clinical deterioration: a two-year prospective cohort study - BMC Infectious Diseases
Background The COVID-19 pandemic has raised concerns about respiratory sequelae, particularly in the patients with preexisting interstitial lung disease (ILD). This study aimed to evaluate the longitu...
link.springer.com
November 25, 2025 at 2:59 PM
Beijing Chao-Yang Hospital followed 347 patients with interstitial lung disease for 2 years and found that those with multiple COVID-19 infections had a 61% rate of disease worsening compared to 42% with a single infection.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Chiang Mai University studied 997 Thai students and found that 21.9% had long COVID symptoms.
Severe initial illness raised risk 15-fold, while each mRNA vaccine dose cut risk by 14%.
link.springer.com/article/10.1...
Severe initial illness raised risk 15-fold, while each mRNA vaccine dose cut risk by 14%.
link.springer.com/article/10.1...
The hidden burden: prevalence and risk factors of long COVID among university students in Chiang Mai, Thailand - BMC Public Health
Background As the COVID-19 pandemic transitions to an endemic phase, long COVID symptoms following SARS-CoV-2 infection have emerged as a new global health challenge. However, its impact on university...
link.springer.com
November 25, 2025 at 2:58 PM
Chiang Mai University studied 997 Thai students and found that 21.9% had long COVID symptoms.
Severe initial illness raised risk 15-fold, while each mRNA vaccine dose cut risk by 14%.
link.springer.com/article/10.1...
Severe initial illness raised risk 15-fold, while each mRNA vaccine dose cut risk by 14%.
link.springer.com/article/10.1...
Cork University researchers reviewed evidence from both human and animal studies suggesting that SARS-CoV-2 can enter and possibly replicate in fat tissue, which may explain worse COVID-19 outcomes in people with obesity.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Adipose Tissue in SARS‐CoV‐2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update
Adipose tissue as a potential reservoir for and modifier of SARS-CoV-2 infection and its complications. Schematic demonstrating the differences in subcutaneous and visceral adipose tissue and infecti...
onlinelibrary.wiley.com
November 25, 2025 at 2:58 PM
Cork University researchers reviewed evidence from both human and animal studies suggesting that SARS-CoV-2 can enter and possibly replicate in fat tissue, which may explain worse COVID-19 outcomes in people with obesity.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Perth researchers imaged 59 adults about 3 months after mild-to-moderate COVID-19 and found lingering inflammation in both lungs and arteries.
The more inflamed the lungs, the more inflamed the vessels, hinting at a link to long-term heart risk.
link.springer.com/article/10.1...
The more inflamed the lungs, the more inflamed the vessels, hinting at a link to long-term heart risk.
link.springer.com/article/10.1...
Persistent lung and vascular inflammation in mild to moderate COVID-19 survivors detected by ¹⁸F-FDG PET/CT: A quantitative imaging study with implications for cardiovascular risk - European Journal o...
Purpose Lingering inflammation after COVID-19 has been proposed as a contributor to long-term cardiovascular risk, yet the link between pulmonary and vascular inflammation remains insufficiently defin...
link.springer.com
November 25, 2025 at 2:57 PM
Perth researchers imaged 59 adults about 3 months after mild-to-moderate COVID-19 and found lingering inflammation in both lungs and arteries.
The more inflamed the lungs, the more inflamed the vessels, hinting at a link to long-term heart risk.
link.springer.com/article/10.1...
The more inflamed the lungs, the more inflamed the vessels, hinting at a link to long-term heart risk.
link.springer.com/article/10.1...
King’s College London researchers gave mice antibodies from post-COVID patients with pain and fatigue.
The mice developed pain and nerve damage, showing these autoantibodies likely cause long COVID sensory symptoms.
www.researchsquare.com/article/rs-7...
The mice developed pain and nerve damage, showing these autoantibodies likely cause long COVID sensory symptoms.
www.researchsquare.com/article/rs-7...
Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome
Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widesprea...
www.researchsquare.com
November 25, 2025 at 2:56 PM
King’s College London researchers gave mice antibodies from post-COVID patients with pain and fatigue.
The mice developed pain and nerve damage, showing these autoantibodies likely cause long COVID sensory symptoms.
www.researchsquare.com/article/rs-7...
The mice developed pain and nerve damage, showing these autoantibodies likely cause long COVID sensory symptoms.
www.researchsquare.com/article/rs-7...
Melbourne researchers studied patients with severe influenza, RSV, and COVID-19 and found that high levels of IL-18 receptor alpha on T cells signal worse disease.
These T cells were highly inflammatory but less able to kill infected cells.
www.nature.com/articles/s41...
These T cells were highly inflammatory but less able to kill infected cells.
www.nature.com/articles/s41...
High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures - Nature Communications
The authors previously pinpointed OLAH (oleoyl-ACP-hydrolase) as a driver of life-threatening viral diseases. Here, the authors identify increased IL-18Rα expression on CD8+ T cells, which acquire a r...
www.nature.com
November 25, 2025 at 1:22 AM
Melbourne researchers studied patients with severe influenza, RSV, and COVID-19 and found that high levels of IL-18 receptor alpha on T cells signal worse disease.
These T cells were highly inflammatory but less able to kill infected cells.
www.nature.com/articles/s41...
These T cells were highly inflammatory but less able to kill infected cells.
www.nature.com/articles/s41...
Monash University researchers enrolled 33 hospitalised COVID-19 patients in a trial of convalescent plasma.
Only 6.7% on plasma needed intensive support or died vs 23.5% on standard care.
The trial ended early, limiting firm conclusions.
onlinelibrary.wiley.com/doi/10.1111/...
Only 6.7% on plasma needed intensive support or died vs 23.5% on standard care.
The trial ended early, limiting firm conclusions.
onlinelibrary.wiley.com/doi/10.1111/...
Convalescent plasma in hospitalised patients with COVID‐19
Background Convalscent plasma (CP) was identified as a potential therapy for COVID-19 available early in the pandemic. Aims To evaluate CP for the treatment of hospitalised adults with COVID-19 wi...
onlinelibrary.wiley.com
November 24, 2025 at 5:45 PM
Monash University researchers enrolled 33 hospitalised COVID-19 patients in a trial of convalescent plasma.
Only 6.7% on plasma needed intensive support or died vs 23.5% on standard care.
The trial ended early, limiting firm conclusions.
onlinelibrary.wiley.com/doi/10.1111/...
Only 6.7% on plasma needed intensive support or died vs 23.5% on standard care.
The trial ended early, limiting firm conclusions.
onlinelibrary.wiley.com/doi/10.1111/...
At the Medical University of Innsbruck, researchers reviewed 120 cases and found that postural orthostatic tachycardia syndrome, or POTS, was the most frequent cardiovascular autonomic disorder diagnosed after COVID-19 infection or vaccination.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Postural orthostatic tachycardia syndrome is the most frequent cardiovascular autonomic disorder following COVID-19 infection or vaccination - Journal of Neurology
Background Cardiovascular autonomic disorders (CAD) were described following COVID-19 infection and vaccination, but previous reports were limited in size and follow-up. Here, we aimed to investigate ...
link.springer.com
November 24, 2025 at 5:43 PM
At the Medical University of Innsbruck, researchers reviewed 120 cases and found that postural orthostatic tachycardia syndrome, or POTS, was the most frequent cardiovascular autonomic disorder diagnosed after COVID-19 infection or vaccination.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Tsinghua University researchers found that a new herbal formula, Jubang Huashi Yin, reduced lung inflammation in COVID-19-infected mice by blocking IKKβ, a key trigger of immune overreaction.
Cynaroside was identified as a key active compound.
www.sciencedirect.com/science/arti...
Cynaroside was identified as a key active compound.
www.sciencedirect.com/science/arti...
Jubang Huashi Yin and its active component cynaroside alleviate excessive inflammation in COVID-19 by inhibiting IKKβ activity
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, triggering a series of immune…
www.sciencedirect.com
November 24, 2025 at 5:43 PM
Tsinghua University researchers found that a new herbal formula, Jubang Huashi Yin, reduced lung inflammation in COVID-19-infected mice by blocking IKKβ, a key trigger of immune overreaction.
Cynaroside was identified as a key active compound.
www.sciencedirect.com/science/arti...
Cynaroside was identified as a key active compound.
www.sciencedirect.com/science/arti...
Researchers at the Federal University of Minas Gerais analyzed data from 3294 people and found that long Covid is linked to persistent elevation of immune signals like IL-6, IFN-γ, and TNF-α, lasting at least 6 months after infection.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Persistent inflammatory cytokine signature in long Covid-19 patients: a meta-analysis - Inflammopharmacology
Post-acute sequelae of Covid-19 (PASC) refer to persistent symptoms lasting weeks to months after acute SARS-CoV-2 infection. However, identifying biological mechanisms, potential therapeutic targets,...
link.springer.com
November 24, 2025 at 5:42 PM
Researchers at the Federal University of Minas Gerais analyzed data from 3294 people and found that long Covid is linked to persistent elevation of immune signals like IL-6, IFN-γ, and TNF-α, lasting at least 6 months after infection.
link.springer.com/article/10.1...
link.springer.com/article/10.1...