aspneph.bsky.social
@aspneph.bsky.social
This Thanksgiving, we’re extra thankful for pediatric nephrologists -
the only people who can make kidneys sound fascinating before the pumpkin pie hits.
Thank you for all you do for kids and families!
November 27, 2025 at 2:02 PM
Lung ultrasonography for assessment of fluid overload in children with acute kidney injury undergoing hemodialysis: a prospective pilot study
#nephsky
Lung ultrasonography for assessment of fluid overload in children with acute kidney injury undergoing hemodialysis: a prospective pilot study - Pediatric Nephrology
Background B-line quantification by lung ultrasonography (LUS) is a non-invasive method to assess pulmonary edema and fluid overload. This study evaluated the change in the number of B-lines on LUS…
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November 26, 2025 at 10:00 PM
Review: Current status and future directions for the use of artificial intelligence in pediatric critical care nephrology
#AI
#nephsky
Current status and future directions for the use of artificial intelligence in pediatric critical care nephrology - Pediatric Nephrology
Artificial intelligence (AI) has the potential to significantly improve the practice of medicine. However, its application in pediatric critical care nephrology remains underdeveloped. This scoping…
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November 26, 2025 at 6:01 PM
Case report: Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome
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Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome - Pediatric Nephrology
Frequently relapsing, steroid-dependent nephrotic syndrome (FRNS/SDNS) remains a therapeutic challenge. Rituximab, a B-cell-depleting agent, is effective and widely used for FRNS/SDNS, but its use…
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November 26, 2025 at 2:01 PM
Review: Viral tubulointerstitial nephritis in children: A narrative review with a focus on adenovirus
Viral tubulointerstitial nephritis in children: A narrative review with a focus on adenovirus - Pediatric Nephrology
Viral infections are well-known causes of systemic illness in children, but their kidney involvement, particularly acute tubulointerstitial nephritis (TIN), remain underdiagnosed and clinically…
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November 26, 2025 at 12:00 AM
All recordings are LIVE! The ASPN Pediatric Nephrology Board Review Course is now available on-demand.
Your pace. Your schedule. Your board prep. buff.ly/mcfs7PK
🔗 #ASPN #PediatricNephrology #BoardPrep
November 25, 2025 at 3:45 PM
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...
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November 25, 2025 at 1:00 AM
The Role of the Vascular Niche in Regulating Kidney Tubulo-Interstitial Fibrosis (review)
November 25, 2025 at 12:00 AM
One-year creatinine predicts long-term graft survival in pediatric kidney transplant recipients
One-year creatinine predicts long-term graft survival in pediatric kidney transplant recipients - Pediatric Nephrology
Background In pediatric kidney transplant, recipients’ long-term graft survival remains variable necessitating methods to predict the timing of graft failure. Studies in adults have identified…
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November 24, 2025 at 9:30 PM
High adherence to angiotensin-converting enzyme inhibitor in children and adolescents with Alport syndrome: objective verification using liquid chromatography-mass spectrometry
High adherence to angiotensin-converting enzyme inhibitor in children and adolescents with Alport syndrome: objective verification using liquid chromatography-mass spectrometry - Pediatric Nephrology
Background Kidney failure (KF) in children and adolescents leads to reduced lifespan and compromised health. Alport syndrome (AS) is a leading hereditary cause of KF in children.…
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November 24, 2025 at 5:30 PM
Serum renin levels refine acute kidney injury prediction in critically ill children
Serum renin levels refine acute kidney injury prediction in critically ill children - Pediatric Nephrology
Background Studies demonstrate that elevated renin is associated with adverse outcomes in critical illness. We aimed to evaluate whether serum renin enhances acute kidney injury (AKI) risk…
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November 24, 2025 at 4:15 PM
Tiopronin safety in cystinuria: first real-world pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS): an EAU YAU and Endourology sections review
Tiopronin safety in cystinuria: first real-world pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS): an EAU YAU and Endourology sections review - Pediatric Nephrology
Background Cystinuria is a rare genetic disorder that causes recurrent cystine stones and significant morbidity, particularly in children. Tiopronin, the main pharmacologic therapy when conservative…
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November 24, 2025 at 11:45 AM
High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants
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High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants - Pediatric Nephrology
Background Acute kidney injury (AKI) is common in very-low-birthweight (VLBW) infants. Both fluid overload and dehydration can lead to AKI. Our aim was to examine the associations between early fluid…
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November 24, 2025 at 1:01 AM
Immunogenicity of the 23-valent polysaccharide pneumococcal vaccine in children with steroid sensitive nephrotic syndrome
Immunogenicity of the 23-valent polysaccharide pneumococcal vaccine in children with steroid sensitive nephrotic syndrome
Background Idiopathic nephrotic syndrome (INS) is the most common chronic kidney disease in childhood, with steroid sensitive nephrotic syndrome (SSNS) as the predominant form. Children with SSNS are...
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November 21, 2025 at 11:15 PM
Heart-kidney transplants linked to better outcomes compared to heart-only transplants in children with non-dialysis-dependent advanced chronic kidney disease
Heart-kidney transplants linked to better outcomes compared to heart-only transplants in children with non-dialysis-dependent advanced chronic kidney disease
Background Chronic kidney disease (CKD) causes significant morbidity and mortality among children with heart failure. Although the survival benefit of a simultaneous heart-kidney transplant has been demonstrated...
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November 21, 2025 at 7:45 PM
Re-evaluating the MYH9 p.I1816V variant in a patient with atypical clinical presentation
Re-evaluating the MYH9 p.I1816V variant in a patient with atypical clinical presentation
MYH9-related disease (MYH9-RD) is an autosomal dominant disorder typically characterized by macrothrombocytopenia, leukocyte inclusion bodies, and variable non-hematologic manifestations such as hearing...
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November 20, 2025 at 7:45 PM
Correlation of serum beta-2 microglobulin with hemodialysis prescription and comorbid factors in children undergoing chronic hemodialysis
Correlation of serum beta-2 microglobulin with hemodialysis prescription and comorbid factors in children undergoing chronic hemodialysis - Pediatric Nephrology
Background Hemodialysis (HD) is a method of kidney replacement therapy designed to remove uremic toxins from the body. Beta-2 microglobulin (beta-2 MG) is a middle molecule not yet effectively…
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November 20, 2025 at 6:30 PM
Clinicopathological characteristics and cyclosporine-responsive proteinuria in nail-patella syndrome with a novel LMX1B mutation
Clinicopathological characteristics and cyclosporine-responsive proteinuria in nail-patella syndrome with a novel LMX1B mutation
Background Nephropathy in nail-patella syndrome (NPS) has limited therapeutic options. Progressive nephrotic-range proteinuria often persists despite maximal renin–angiotensin–aldosterone system inhibitor...
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November 20, 2025 at 3:03 PM
The dietary management of sodium in children with kidney diseases—clinical practice recommendations from the Pediatric Renal Nutrition Taskforce
The dietary management of sodium in children with kidney diseases—clinical practice recommendations from the Pediatric Renal Nutrition Taskforce
Sodium imbalance is a common concern in children with kidney diseases, presenting as either sodium excess or sodium deficit, each with significant clinical implications. Sodium excess contributes to fluid...
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November 20, 2025 at 9:37 AM
Relationships between galectin-3, sclerostin and arterial stiffness in children with renal scar
Relationships between galectin-3, sclerostin and arterial stiffness in children with renal scar - Pediatric Nephrology
Background Renal scar can lead to hypertension and cardiovascular disease in children. Arterial stiffness is an important endpoint in the development of cardiovascular diseases and is a guide in the…
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November 19, 2025 at 11:00 PM
Giving monocytes their due: How CD47–SIRP-α reframes allograft rejection
Giving monocytes their due: How CD47–SIRP-α reframes allograft rejection
Despite decades of therapeutic innovation targeting adaptive immunity, such as the development of calcineurin inhibitors and B-cell–depleting agents like rituximab, long-term graft survival rates…
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November 19, 2025 at 5:52 PM
From RAAS blockade to regenerative medicine: evolving treatment strategies in Alport syndrome (review)
From RAAS blockade to regenerative medicine: evolving treatment strategies in Alport syndrome
Alport syndrome (AS) is a hereditary glomerulopathy caused by mutations in the COL4A3, COL4A4, or COL4A5 genes, leading to progressive kidney decline and extrarenal manifestations. Advances in genetic...
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November 19, 2025 at 5:30 PM
Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes?
Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes?
Background Diabetic kidney disease (DKD) is the primary cause of kidney failure in type 1 diabetes (T1D). Early identification of subclinical DKD is based on albuminuria and glomerular filtration rate...
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November 19, 2025 at 2:53 PM
Prolonged hypotension in children with bilateral kidney absence: a case series and pathophysiologic insights
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Prolonged hypotension in children with bilateral kidney absence: a case series and pathophysiologic insights - Pediatric Nephrology
Background The renin–angiotensin–aldosterone system is essential for blood pressure regulation, and its absence in children with bilateral kidney loss predisposes them to hypotension unresponsive to…
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November 17, 2025 at 9:01 PM