Anthony Schuller
@aschuller17.bsky.social
Director of Biology @ Interdict Bio | Previously @ Nogales Lab (Berkeley), Schwartz Lab (MIT), Green Lab (Johns Hopkins) | Drug discovery, ribosomes, protein & RNA biochemistry, cryo-EM, cryo-ET.
Reposted by Anthony Schuller
This one is mostly about the title subject (featuring a very interesting compound from academia) but it’s also about attacking the NIH:
Attacking Estrogen-Receptor-Positive Breast Cancer
www.science.org
January 24, 2025 at 7:16 PM
This one is mostly about the title subject (featuring a very interesting compound from academia) but it’s also about attacking the NIH:
Reposted by Anthony Schuller
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
January 10, 2025 at 8:00 PM
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
Reposted by Anthony Schuller
Excited to share the 1st preprint from our incredible team at Interdict Bio as we progress novel, small-molecule sequence-selective inhibitors of translation toward the clinic to address difficult to treat cancers! #ribosome #interdictor
Check out the preprint here: www.biorxiv.org/content/10.1...
Check out the preprint here: www.biorxiv.org/content/10.1...
Context-dependent translation inhibition as a novel oncology therapeutic modality
Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...
www.biorxiv.org
January 22, 2025 at 4:09 AM
Excited to share the 1st preprint from our incredible team at Interdict Bio as we progress novel, small-molecule sequence-selective inhibitors of translation toward the clinic to address difficult to treat cancers! #ribosome #interdictor
Check out the preprint here: www.biorxiv.org/content/10.1...
Check out the preprint here: www.biorxiv.org/content/10.1...