Anton Henssen
@anton-henssen.bsky.social
Head of preclinical pediatric cancer research @ChariteBerlin ECRC @MDC_Berlin. Extrachromosomal DNA (ecDNA) in cancer. Cancer Grand Challenges Team eDyNAmiC
So nice to see our work out in print! Very special to have two of our eDyNAmiC papers in the same issue. What a beautiful cover! Thank you @elizsmckenna.bsky.social !! @aacrjournals.bsky.social
The October issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features two papers on the role of #ecDNA heterogeneity in tumor evolution and adaptation to therapy - you can find these papers and much more here: aacrjournals.org/cancerdiscov...
October 7, 2025 at 3:23 PM
So nice to see our work out in print! Very special to have two of our eDyNAmiC papers in the same issue. What a beautiful cover! Thank you @elizsmckenna.bsky.social !! @aacrjournals.bsky.social
Thank you for inviting me to talk alongside Ido about our work on ecDNA!
We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!
September 25, 2025 at 10:53 AM
Thank you for inviting me to talk alongside Ido about our work on ecDNA!
Reposted by Anton Henssen
Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...
August 13, 2025 at 11:30 AM
Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...
Reposted by Anton Henssen
A huge thank you to all #IEAwards25 winners and nominees for an inspiring evening. We can’t wait to see what’s next on your horizon.
Read more: bit.ly/44m94a0
#OnMyHorizon @anton-henssen.bsky.social, @nnennayakanu.bsky.social, @michellecruk.bsky.social @timwitney.bsky.social, @cuh.nhs.uk
Read more: bit.ly/44m94a0
#OnMyHorizon @anton-henssen.bsky.social, @nnennayakanu.bsky.social, @michellecruk.bsky.social @timwitney.bsky.social, @cuh.nhs.uk
July 11, 2025 at 2:31 PM
A huge thank you to all #IEAwards25 winners and nominees for an inspiring evening. We can’t wait to see what’s next on your horizon.
Read more: bit.ly/44m94a0
#OnMyHorizon @anton-henssen.bsky.social, @nnennayakanu.bsky.social, @michellecruk.bsky.social @timwitney.bsky.social, @cuh.nhs.uk
Read more: bit.ly/44m94a0
#OnMyHorizon @anton-henssen.bsky.social, @nnennayakanu.bsky.social, @michellecruk.bsky.social @timwitney.bsky.social, @cuh.nhs.uk
Reposted by Anton Henssen
I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social.
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers
AbstractExtrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance throug...
aacrjournals.org
August 8, 2025 at 10:22 AM
I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social.
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
Reposted by Anton Henssen
@anton-henssen.bsky.social we are looking forward to your presentation at #ecDNA25 in Mexico! Please share with your followers to let them know our early bird registration & talk submission close on 02 June 2025!
💰Grants available
✅More info: bit.ly/42XY0za
💰Grants available
✅More info: bit.ly/42XY0za
May 14, 2025 at 2:22 PM
@anton-henssen.bsky.social we are looking forward to your presentation at #ecDNA25 in Mexico! Please share with your followers to let them know our early bird registration & talk submission close on 02 June 2025!
💰Grants available
✅More info: bit.ly/42XY0za
💰Grants available
✅More info: bit.ly/42XY0za
Reposted by Anton Henssen
🚨🚨Paper out! 🚨🚨
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
June 10, 2025 at 3:26 PM
🚨🚨Paper out! 🚨🚨
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
Delighted to share our work, now published in @natgenet.nature.com 🧬!
shorturl.at/94s5S
We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n
Illustration: Hratch Arbach
🧵👇
Congrats Juliane and Monika authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
April 5, 2025 at 8:59 PM
Congrats Juliane and Monika authors.elsevier.com/sd/article/S...
Reposted by Anton Henssen
New @theaacr.bsky.social Cancer Discovery paper on ecDNA in urothelial carcinoma reveals how ecDNAs:
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and Tumor-Immune Microenvironment
Abstract. Extrachromosomal DNA (ecDNA) presents a promising target for cancer therapy; however, its spatial-temporal diversity and influence on tumor evolution and the immune microenvironment remain l...
aacrjournals.org
March 11, 2025 at 2:39 PM
New @theaacr.bsky.social Cancer Discovery paper on ecDNA in urothelial carcinoma reveals how ecDNAs:
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
💡 Drive #BladderCancer evolution
💡 Promote immune evasion
💡 Amplify oncogenes
💡 Fuel tumour heterogeneity
💡 May be a biomarker in urine for non-invasive detection
aacrjournals.org/cancerdiscov...
Great conference ! I look forward to attending. 🔥🔥👇🏻👇🏻
#ecDNA is reshaping biomedical science. Now recognized as a key player in ~30% of cancer patients, understanding its biology could unlock new therapeutic strategies for #cancer & other diseases. Join us at #ecDNA25 for discussions at the forefront of this rapidly advancing field ➡️ bit.ly/XecDNA25
February 13, 2025 at 8:26 PM
Great conference ! I look forward to attending. 🔥🔥👇🏻👇🏻
Exciting new paper 🔥🔥👇🏻👇🏻
Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...
www.science.org
January 31, 2025 at 9:46 PM
Exciting new paper 🔥🔥👇🏻👇🏻
Great conference with expert lineup ! I look forward to attending! 🔥🔥👇🏻👇🏻
January 23, 2025 at 7:46 PM
Great conference with expert lineup ! I look forward to attending! 🔥🔥👇🏻👇🏻
Reposted by Anton Henssen
The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...
Complex rearrangements fuel ER+ and HER2+ breast tumours - Nature
A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the p...
www.nature.com
January 8, 2025 at 10:58 PM
The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...
Reposted by Anton Henssen
Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids:
@danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org
www.science.org/doi/10.1126/...
@danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org
www.science.org/doi/10.1126/...
Rare germline structural variants increase risk for pediatric solid tumors
Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using ge...
www.science.org
January 2, 2025 at 11:38 PM
Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids:
@danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org
www.science.org/doi/10.1126/...
@danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org
www.science.org/doi/10.1126/...
🔥🔥👇🏻👇🏻
Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers
Inherited genome instability
Germline structural variants are a risk factor for pediatric extracranial solid tumors
www.science.org
January 3, 2025 at 11:54 AM
🔥🔥👇🏻👇🏻
🔥🔥👇🏻👇🏻
End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?
January 1, 2025 at 10:49 AM
🔥🔥👇🏻👇🏻
Important work by Heribert Jürgens and colleagues on how telemedicine can improve the management of patients suffering from sarcoma. 👏🏻👏🏻👇🏻👇🏻
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
December 21, 2024 at 7:30 AM
Important work by Heribert Jürgens and colleagues on how telemedicine can improve the management of patients suffering from sarcoma. 👏🏻👏🏻👇🏻👇🏻
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Major milestone in ecDNA research!!! 👏🏻👏🏻👏🏻🔥🔥🔥👇🏻👇🏻
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:58 PM
Major milestone in ecDNA research!!! 👏🏻👏🏻👏🏻🔥🔥🔥👇🏻👇🏻
Reposted by Anton Henssen
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
December 17, 2024 at 12:56 AM
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
Reposted by Anton Henssen
Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia
Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...
www.biorxiv.org
December 13, 2024 at 9:07 PM
Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anton Henssen
Great to see our joint study with @stesantaguida.bsky.social published in this month’s issue of Cancer Discovery:
aacrjournals.org/cancerdiscov...
With a super-kind Research Highlight written by Sam Bakhoum:
aacrjournals.org/cancerdiscov...
With a super-kind Research Highlight written by Sam Bakhoum:
Targeting RNA and Protein Turnover in Aneuploid Cancers
Summary:. Aneuploidy, an imbalance in chromosome number, is a hallmark of human cancers with chromosomal instability, and it remains a major therapeutic challenge. In this issue, Ippolito and colleagu...
aacrjournals.org
December 3, 2024 at 8:06 AM
Great to see our joint study with @stesantaguida.bsky.social published in this month’s issue of Cancer Discovery:
aacrjournals.org/cancerdiscov...
With a super-kind Research Highlight written by Sam Bakhoum:
aacrjournals.org/cancerdiscov...
With a super-kind Research Highlight written by Sam Bakhoum:
👏🏻👏🏻👏🏻🔥🔥👇🏻👇🏻
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
December 1, 2024 at 1:03 PM
👏🏻👏🏻👏🏻🔥🔥👇🏻👇🏻
Reposted by Anton Henssen
Social media is in desperate need of innovation. Meta is only letting you have a slice of control over what you see because Bluesky is here building for you.
We wrote on Saturday about how Meta is going all-out to meet the threat of Bluesky: wapo.st/3OrYxBj
Today they took another step— finally allowing users to set their default feeds to a chronological “following” feed.
Today they took another step— finally allowing users to set their default feeds to a chronological “following” feed.
November 26, 2024 at 2:54 AM
Social media is in desperate need of innovation. Meta is only letting you have a slice of control over what you see because Bluesky is here building for you.
Amazing idea ! Hope it works. Would be very valuable method for early detection.
The BEST4 Screening trial has welcomed its first participants. The trial funded by @cancerresearchuk.org and @nihr.bsky.social will find out if a capsule sponge test can screen for oesophageal cancer. @cuhnhs.bsky.social @cambridgeuni.bsky.social
More ➡️ crukcambridgecentre.org.uk/news/pill-th...
More ➡️ crukcambridgecentre.org.uk/news/pill-th...
November 28, 2024 at 7:36 PM
Amazing idea ! Hope it works. Would be very valuable method for early detection.
Reposted by Anton Henssen
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌
Apply before Feb 15th
📌
November 28, 2024 at 7:21 PM
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌
Apply before Feb 15th
📌