I’m talking on this topic at an ELRIG meeting in London. Your well informed commentary is super helpful. Thanks

Concur on the over hype dmd lack of clarity. The tech can make a difference but certainly not alone

6. Impact on Young Adults: Children in hospices often survive longer due to excellent care. As they transition to adulthood, they may face a societal view that expedites their death, adding stress to their well-being.

4. Ethical Juxtaposition: In hospitals, critical care and mental health departments strive to save lives, while another department facilitates assisted dying. This juxtaposition raises ethical concerns and likely many legal questions.

How large will be the money motion be and is it in the government budget?

3. Healthcare Resources: How will doctors' time be allocated to support this process? Can the government ensure funding for necessary resources? Are mental health experts, skilled in capability assessment, prepared to take on this responsibility amidst existing NHS pressures?

2. Substances Used: What compounds will be used? Will they be similar to those used on death row, How long does it take for a person to die after self-administration, what safeguards will prevent people from ordering these compounds online? Will NICE approve these but not life extending medication?

1. Medical Training: How will medical training and the Hippocratic Oath be adapted? Will the General Medical Council (GMC) engage in this process? Many Dr’s did not agree to this. Will many refuse on ethical grounds, leave or retire early? What will happen when the first dose doesn’t work?

It’s driven by the same concern and compassion for suffering people’s comfort.
More detailed reasons to follow :

This is super as it helps crystallise how I’ve made most progress , it’s always been through science chat with 1 other person. Thank you, never saw it this clearly before

that’s one if the reasons I chose to invest in my children’s education through independent (not private) education

The challenge now is to integrate and embed this tech with the daily work of the drug discovery and precision medicine scientists.

The competition winners optimised existing mAbs and ligands - always a good optimisation strategy. For me seeing novel proteins and peptides (from PLMs, Bindcraft & RSO), bivalent avid binders, and a focus on computational efficiency was especially exciting.

🚀 Also great to see the first Biologics protein design competition by Adaptyv Bio readout. The challenge: Who can use the AI/ML tech of their choice to make a novel EGFR binder? foundry.adaptyvbio.com/competition