Amy Kuceyeski
@amykooz.bsky.social
Professor | Weill Cornell Medicine Radiology & Cornell University.
Computational neuroimaging, women’s brain health, neuroAI, psychedelics, brain-behavior mapping. Mom, jogger, avid reader.
Lab site: cocolaboratory.com
Bowers WBHI: wbhi.ucsb.edu
Computational neuroimaging, women’s brain health, neuroAI, psychedelics, brain-behavior mapping. Mom, jogger, avid reader.
Lab site: cocolaboratory.com
Bowers WBHI: wbhi.ucsb.edu
This work was led by the brilliant Louisa Schilling, with assists from @parkersingleton.bsky.social, @cerentozlu.bsky.social, @qingyuz.bsky.social, Keith Jamison, Kilian Pohl, and Marie Hedo.
We would like to also thank our funders, particularly @bowers-wbhi.bsky.social, as well as the NIH & BBRF.
We would like to also thank our funders, particularly @bowers-wbhi.bsky.social, as well as the NIH & BBRF.
November 21, 2025 at 4:38 PM
This work was led by the brilliant Louisa Schilling, with assists from @parkersingleton.bsky.social, @cerentozlu.bsky.social, @qingyuz.bsky.social, Keith Jamison, Kilian Pohl, and Marie Hedo.
We would like to also thank our funders, particularly @bowers-wbhi.bsky.social, as well as the NIH & BBRF.
We would like to also thank our funders, particularly @bowers-wbhi.bsky.social, as well as the NIH & BBRF.
🧠 Together, these findings highlight early, measurable, and sex-differentiated neural mechanisms of SUD risk. This opens the door to earlier, better, targeted prediction, prevention, and intervention.
Full article: www.nature.com/articles/s44...
Summary: news.weill.cornell.edu/news/2025/11...
Full article: www.nature.com/articles/s44...
Summary: news.weill.cornell.edu/news/2025/11...
Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder - Nature Mental Health
This study investigates how family history influences brain dynamics related to substance use disorder, utilizing network control theory to reveal sex-specific alterations in transition energies acros...
www.nature.com
November 21, 2025 at 4:38 PM
🧠 Together, these findings highlight early, measurable, and sex-differentiated neural mechanisms of SUD risk. This opens the door to earlier, better, targeted prediction, prevention, and intervention.
Full article: www.nature.com/articles/s44...
Summary: news.weill.cornell.edu/news/2025/11...
Full article: www.nature.com/articles/s44...
Summary: news.weill.cornell.edu/news/2025/11...
♂ Males with family history of SUD (FH+) had reduced TE, especially in dorsal and ventral attention networks. We posit FH+ males may find it easier to “step on the gas” in attentional systems, reacting more easily to environmental cues and the rewarding aspects of substance use.
November 21, 2025 at 4:38 PM
♂ Males with family history of SUD (FH+) had reduced TE, especially in dorsal and ventral attention networks. We posit FH+ males may find it easier to “step on the gas” in attentional systems, reacting more easily to environmental cues and the rewarding aspects of substance use.
♀ Females with SUD family history (FH+) showed increased TE, particularly in the default mode (the part of the brain active “at rest”). Thus, FH+ females may find it harder to “pump the brakes” in higher-order networks to inhibit impulses related to substance use.
November 21, 2025 at 4:38 PM
♀ Females with SUD family history (FH+) showed increased TE, particularly in the default mode (the part of the brain active “at rest”). Thus, FH+ females may find it harder to “pump the brakes” in higher-order networks to inhibit impulses related to substance use.
⚡ To determine how Transition Energy (TE, the amount of “effort” the brain needs to move between activity states) differs by sex and SUD family history, we applied network control theory. Using resting-state fMRI data from ~2,000 ABCD youth, we quantified TE at global, network, and regional levels.
November 21, 2025 at 4:38 PM
⚡ To determine how Transition Energy (TE, the amount of “effort” the brain needs to move between activity states) differs by sex and SUD family history, we applied network control theory. Using resting-state fMRI data from ~2,000 ABCD youth, we quantified TE at global, network, and regional levels.
Reposted by Amy Kuceyeski
June 23, 2025 at 10:44 PM
5) sex differences in ADHD - Natalia Prieto, and, of course, our posters using Network Control Theory to analyze brain dynamics in 6) cocaine use disorder - Hussain Al-Bukhari, 7) mild cognitive impairment - Daran Neumann, and 8) varied sleep quality - Anthony Villegas. Great work CoCo Lab!
June 24, 2025 at 6:47 PM
5) sex differences in ADHD - Natalia Prieto, and, of course, our posters using Network Control Theory to analyze brain dynamics in 6) cocaine use disorder - Hussain Al-Bukhari, 7) mild cognitive impairment - Daran Neumann, and 8) varied sleep quality - Anthony Villegas. Great work CoCo Lab!
Also see the WCM Newsroom story! news.weill.cornell.edu/news/2025/06...
Mapping the Connections Between the Brain’s Structure and Function
Using an algorithm they call the Krakencoder, researchers at Weill Cornell Medicine are a step closer to unraveling how the brain’s wiring supports how we think and act.
news.weill.cornell.edu
June 5, 2025 at 2:56 PM
Also see the WCM Newsroom story! news.weill.cornell.edu/news/2025/06...
In collaboration with @msabuncu.bsky.social @cerentozlu.bsky.social Zijin Gu and others!
June 5, 2025 at 2:02 PM
In collaboration with @msabuncu.bsky.social @cerentozlu.bsky.social Zijin Gu and others!
We also wrote a research briefing about the article: www.nature.com/articles/s41...
Krakencoder unifies diverse estimates of brain connectivity - Nature Methods
In neuroscience, numerous complementary techniques have been established to estimate human brain connections in vivo. We have created a tool that aligns complementary views of brain connectivity into ...
www.nature.com
June 5, 2025 at 1:55 PM
We also wrote a research briefing about the article: www.nature.com/articles/s41...
Reposted by Amy Kuceyeski
This project was a fun collaboration between a bunch of super cool people, including @richardfbetzel.bsky.social, @ahmadbeyh.bsky.social, Amber Howell, @amykooz.bsky.social,
@bart-larsen.bsky.social, Caio Seguin, @xi-hanzhang.bsky.social, and @avramholmes.bsky.social!
@bart-larsen.bsky.social, Caio Seguin, @xi-hanzhang.bsky.social, and @avramholmes.bsky.social!
a woman wearing a wig and a suit says " whatever you do "
ALT: a woman wearing a wig and a suit says " whatever you do "
media.tenor.com
April 28, 2025 at 1:01 PM
This project was a fun collaboration between a bunch of super cool people, including @richardfbetzel.bsky.social, @ahmadbeyh.bsky.social, Amber Howell, @amykooz.bsky.social,
@bart-larsen.bsky.social, Caio Seguin, @xi-hanzhang.bsky.social, and @avramholmes.bsky.social!
@bart-larsen.bsky.social, Caio Seguin, @xi-hanzhang.bsky.social, and @avramholmes.bsky.social!