Amulya Sreekumar
@amulyasreekumar.bsky.social
Research Associate - Chodosh Lab (Dept. of Cancer Biology, University of Pennsylvania)
Cancer Biology | Dormancy | Developmental Biology | Glycobiology
Cancer Biology | Dormancy | Developmental Biology | Glycobiology
Reposted by Amulya Sreekumar
Check our new venture into drug discovery #glycotime!
Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase
O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...
chemrxiv.org
October 7, 2025 at 6:11 AM
Check our new venture into drug discovery #glycotime!
Comprehensive experiments in pre-clinical models and clinical data analysis demonstrate that dormancy creates a unique window of opportunity to deplete minimal residual disease and delay recurrence. Congratulations to all the authors on this important body of work!
Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial - Nature Medicine
A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells followin...
www.nature.com
September 3, 2025 at 8:35 PM
Comprehensive experiments in pre-clinical models and clinical data analysis demonstrate that dormancy creates a unique window of opportunity to deplete minimal residual disease and delay recurrence. Congratulations to all the authors on this important body of work!
Reposted by Amulya Sreekumar
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
www.nature.com
July 28, 2025 at 9:44 AM
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Reposted by Amulya Sreekumar
World central kitchen has been doing great work consistently. Every meal counts. Donate here.
donate.wck.org/give/525879/...
donate.wck.org/give/525879/...
July 26, 2025 at 10:13 AM
World central kitchen has been doing great work consistently. Every meal counts. Donate here.
donate.wck.org/give/525879/...
donate.wck.org/give/525879/...
As a budding scientist, the idea that form follows function led me to a career studying developmental biology and how these principles are distorted in cancer. Excited to share this preprint reporting a surprising transdifferentiation of breast cancer cells unlocked by dormancy. Link below:
Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy https://www.biorxiv.org/content/10.1101/2025.05.07.652632v1
May 10, 2025 at 8:45 PM
As a budding scientist, the idea that form follows function led me to a career studying developmental biology and how these principles are distorted in cancer. Excited to share this preprint reporting a surprising transdifferentiation of breast cancer cells unlocked by dormancy. Link below:
Reposted by Amulya Sreekumar
Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...
AACR Legislative Action Center
Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...
nam02.safelinks.protection.outlook.com
February 18, 2025 at 10:27 PM
Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...
Reposted by Amulya Sreekumar
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods
Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...
www.nature.com
February 6, 2025 at 10:59 PM
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Amulya Sreekumar
Apply for our Pathway to Independence programme, a scheme supporting postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. Apply by 31 Jan 2025: https://buff.ly/3VJGgDC
December 27, 2024 at 9:51 AM
Apply for our Pathway to Independence programme, a scheme supporting postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. Apply by 31 Jan 2025: https://buff.ly/3VJGgDC
Reposted by Amulya Sreekumar
#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!
November 16, 2024 at 2:06 PM
#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!
Reposted by Amulya Sreekumar
The secret is out! 🚀 Thrilled to support Valora's mission to bring our #AbLec technology to patients, alongside co-inventor @carolynbertozzi.bsky.social. More to come, and in the meantime, you can learn more about AbLecs here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 20, 2024 at 10:48 PM
The secret is out! 🚀 Thrilled to support Valora's mission to bring our #AbLec technology to patients, alongside co-inventor @carolynbertozzi.bsky.social. More to come, and in the meantime, you can learn more about AbLecs here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Amulya Sreekumar
Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
November 20, 2024 at 10:46 AM
Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
Reposted by Amulya Sreekumar
Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered #glycan profiles between mouse, NHP and human liver, with implications for translation of #AAV #genetherapy
pubmed.ncbi.nlm.nih.gov/39001819/
Enjoy!
pubmed.ncbi.nlm.nih.gov/39001819/
Enjoy!
Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity - PubMed
Effective use of adeno-associated viruses (AAVs) for clinical gene therapy is limited by their propensity to accumulate in and transduce the liver. This natural liver tropism is associated with severe...
pubmed.ncbi.nlm.nih.gov
November 19, 2024 at 2:20 PM
Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered #glycan profiles between mouse, NHP and human liver, with implications for translation of #AAV #genetherapy
pubmed.ncbi.nlm.nih.gov/39001819/
Enjoy!
pubmed.ncbi.nlm.nih.gov/39001819/
Enjoy!
Thank you to the organizers of #SFG2024 for hosting a wonderful meeting @sfglycobiology.bsky.social
As a 1st time attendee, it was a privilege to present my work on B3galt6-heparan sulfate biosynthesis as a functional regulator of dormant breast cancer cell survival.
www.cell.com/cancer-cell/...
As a 1st time attendee, it was a privilege to present my work on B3galt6-heparan sulfate biosynthesis as a functional regulator of dormant breast cancer cell survival.
www.cell.com/cancer-cell/...
B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
Sreekumar et al. identify a previously uncharacterized function for the galactosyltransferase
B3galt6 in cancer, specifically enabling dormant residual tumor cell survival following
therapy or in a re...
www.cell.com
November 17, 2024 at 3:26 PM
Thank you to the organizers of #SFG2024 for hosting a wonderful meeting @sfglycobiology.bsky.social
As a 1st time attendee, it was a privilege to present my work on B3galt6-heparan sulfate biosynthesis as a functional regulator of dormant breast cancer cell survival.
www.cell.com/cancer-cell/...
As a 1st time attendee, it was a privilege to present my work on B3galt6-heparan sulfate biosynthesis as a functional regulator of dormant breast cancer cell survival.
www.cell.com/cancer-cell/...
Reposted by Amulya Sreekumar
#SFG24 was so much fun - amazing #glycotime in a fantastic place. The right mix between talks by legends in the field and early career colleagues. Thank you to the organizers!
I contributed our own story on xylosyltransferase bump-and-hole engineering, check here: www.biorxiv.org/content/10.1...
I contributed our own story on xylosyltransferase bump-and-hole engineering, check here: www.biorxiv.org/content/10.1...
November 16, 2024 at 1:45 PM
#SFG24 was so much fun - amazing #glycotime in a fantastic place. The right mix between talks by legends in the field and early career colleagues. Thank you to the organizers!
I contributed our own story on xylosyltransferase bump-and-hole engineering, check here: www.biorxiv.org/content/10.1...
I contributed our own story on xylosyltransferase bump-and-hole engineering, check here: www.biorxiv.org/content/10.1...
Reposted by Amulya Sreekumar
For those of you that prefer feeds over following, I've figured out how to convert starter packs into lists, so you can get your glyco fix as a feed. If you're on the starter pack, you're on the list, and anyone new on the starter pack will get added to the feed!
November 17, 2024 at 1:05 PM
For those of you that prefer feeds over following, I've figured out how to convert starter packs into lists, so you can get your glyco fix as a feed. If you're on the starter pack, you're on the list, and anyone new on the starter pack will get added to the feed!
Reposted by Amulya Sreekumar
It seems to me that the time is ripe for a Bluesky thread about how—and maybe even why—to befriend crows.
(1/n)
(1/n)
August 20, 2023 at 1:55 AM
It seems to me that the time is ripe for a Bluesky thread about how—and maybe even why—to befriend crows.
(1/n)
(1/n)
As someone who has gained a lot of knowledge and career advice from fellow glycobiologists, I wanted to recreate a space for discussion on Bluesky. Here's a starter pack with some glycobiology users to get started. Please comment/DM me to get added to the #glycotime starter pack
go.bsky.app/CN9pS3u
go.bsky.app/CN9pS3u
November 12, 2024 at 12:33 AM
As someone who has gained a lot of knowledge and career advice from fellow glycobiologists, I wanted to recreate a space for discussion on Bluesky. Here's a starter pack with some glycobiology users to get started. Please comment/DM me to get added to the #glycotime starter pack
go.bsky.app/CN9pS3u
go.bsky.app/CN9pS3u
Reposted by Amulya Sreekumar
Happy to announce that, on the eve of this year's Society for Glycobiology meeting, my second paper from my collaboration with the great Nancy Dahms is out!
Really proud of this one. Biggest protein we've ever footprinted, a real challenge! #glycotime 🧪
Really proud of this one. Biggest protein we've ever footprinted, a real challenge! #glycotime 🧪
Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2 - Scientific Reports
Scientific Reports - Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2
www.nature.com
November 11, 2024 at 1:07 AM
Happy to announce that, on the eve of this year's Society for Glycobiology meeting, my second paper from my collaboration with the great Nancy Dahms is out!
Really proud of this one. Biggest protein we've ever footprinted, a real challenge! #glycotime 🧪
Really proud of this one. Biggest protein we've ever footprinted, a real challenge! #glycotime 🧪