I'm very thankful to everyone involved in the study! The project would not have been possible without my co-firsts Karen Grimes and Hyobin Jeong and co-lasts Andreas Trumpp, Jan Korbel and Ashley Sanders 🎉 🎊 5/5

In another patient with paired pre- and post-treatment samples, two distinct subclones persisted post venetoclax-based treatment. Both had subclone-specific mechanisms to further resistance: a shift toward MEP-like cells and NF1 loss. Go and read more about the other cases! 📜 4/5

For example, in one patient the sublclone driving relapse had a seismic amplification, upregulated DNA damage response and it also engrafted in mice. We could even see cell-to-cell differences in the copy-number states of the seismic amplification! 🌋 3/5

We integrated single-cell resolution structural variants, nucleosome occupancy, gene expression and surface proteins to study subclonal growth patterns in complex karyotype AML patient samples 🧬 2/5