Andrew Glazer
@amglazer.bsky.social
Assistant Professor at Vanderbilt Univ. Medical Center. Arrhythmia genetics, ion channels, high-throughput methods. http://andrewglazerlab.com.
Variants with severe loss-of-function had ~25% penetrance & 501x increased odds of BrS. Normal-function variants had lower risk. This work stratifies SCN5A variants into low-risk vs high-risk categories, aiding diagnosis & management for patients & families. [3/4]
November 20, 2025 at 7:22 PM
Variants with severe loss-of-function had ~25% penetrance & 501x increased odds of BrS. Normal-function variants had lower risk. This work stratifies SCN5A variants into low-risk vs high-risk categories, aiding diagnosis & management for patients & families. [3/4]
Using our calibrated automated patch clamp assay, we identified 146 abnormal function variants and reclassified 110 VUS. [2/4]
November 20, 2025 at 7:22 PM
Using our calibrated automated patch clamp assay, we identified 146 abnormal function variants and reclassified 110 VUS. [2/4]
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
November 20, 2025 at 7:22 PM
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
Congrats to Matthew O'Neill for winning an American Heart Association Early Career award for our work on functional studies of SCN5A variants from patients with Brugada syndrome!
November 10, 2025 at 1:31 AM
Congrats to Matthew O'Neill for winning an American Heart Association Early Career award for our work on functional studies of SCN5A variants from patients with Brugada syndrome!
I gave my daughter C, A, and T cards to spell "cat." She grabbed a G and added it to the mix. Is she hinting at a future career in genetics? 🧬 🐾
September 23, 2025 at 5:31 PM
I gave my daughter C, A, and T cards to spell "cat." She grabbed a G and added it to the mix. Is she hinting at a future career in genetics? 🧬 🐾
📝Check out our review “Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine”, out in @natrevcardiol.nature.com. We review the use of Multiplexed Assays of Variant Effect and variant effect predictors in cardiovascular disease.
September 3, 2025 at 7:03 PM
📝Check out our review “Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine”, out in @natrevcardiol.nature.com. We review the use of Multiplexed Assays of Variant Effect and variant effect predictors in cardiovascular disease.
Having some summer fun...Glazer Lab Olympics! Our lab competed in 6 lab-themed events.
July 16, 2025 at 2:56 PM
Having some summer fun...Glazer Lab Olympics! Our lab competed in 6 lab-themed events.
My wife and I had a lovely time in Spain, including the excellent #VariantEffect25 meeting!
May 25, 2025 at 8:09 AM
My wife and I had a lovely time in Spain, including the excellent #VariantEffect25 meeting!
It was great to attend the ACMG clinical genetics meeting for the first time, including a fun session on advances in cardiovascular genomics.
March 22, 2025 at 1:00 AM
It was great to attend the ACMG clinical genetics meeting for the first time, including a fun session on advances in cardiovascular genomics.
Disease risk was proportional to the severity of loss-of-function; variants with Z ≤ -6 had a penetrance of 24.5% and an odds ratio of 501 for BrS. [5/7]
March 20, 2025 at 1:53 AM
Disease risk was proportional to the severity of loss-of-function; variants with Z ≤ -6 had a penetrance of 24.5% and an odds ratio of 501 for BrS. [5/7]
Out of 252 variants, 146 were functionally abnormal (Z ≤ -2), with 100 showing severe loss-of-function (Z ≤ -4). Functional evidence allowed us to reclassify 110 of 225 VUS: 104 to likely pathogenic and 6 to likely benign. [4/7]
March 20, 2025 at 1:53 AM
Out of 252 variants, 146 were functionally abnormal (Z ≤ -2), with 100 showing severe loss-of-function (Z ≤ -4). Functional evidence allowed us to reclassify 110 of 225 VUS: 104 to likely pathogenic and 6 to likely benign. [4/7]
Using automated patch clamp, we analyzed 252 SCN5A variants from a previously published cohort of 3,335 BrS cases. We previously showed this assay performs well on benign/pathogenic controls. The controls were used to calculate normalized Z-scores for the 252 variants. [3/7]
March 20, 2025 at 1:53 AM
Using automated patch clamp, we analyzed 252 SCN5A variants from a previously published cohort of 3,335 BrS cases. We previously showed this assay performs well on benign/pathogenic controls. The controls were used to calculate normalized Z-scores for the 252 variants. [3/7]
🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]
March 20, 2025 at 1:53 AM
🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]
Congrats Ellen on winning the lab ping pong tournament!
January 31, 2025 at 6:42 PM
Congrats Ellen on winning the lab ping pong tournament!
Just updated this figure for 2025. There are now over 1 million missense Variants of Uncertain Significance in Clinvar!
January 24, 2025 at 9:08 PM
Just updated this figure for 2025. There are now over 1 million missense Variants of Uncertain Significance in Clinvar!
Congrats to my PhD student Trey who received an American Heart Association fellowship!
December 19, 2024 at 4:35 PM
Congrats to my PhD student Trey who received an American Heart Association fellowship!
Learning about Bayesian statistics from Ellen (grad student in the lab)! I'm now prepared to cite some Bayesian math if I ever get pulled over for a Breathalyzer test.
December 5, 2024 at 5:03 PM
Learning about Bayesian statistics from Ellen (grad student in the lab)! I'm now prepared to cite some Bayesian math if I ever get pulled over for a Breathalyzer test.
It was great to attend the American Heart Association meeting in my hometown of Chicago. I took my daughter to visit her grandma and she got to sit in the cockpit on the flight home!
November 22, 2024 at 3:22 AM
It was great to attend the American Heart Association meeting in my hometown of Chicago. I took my daughter to visit her grandma and she got to sit in the cockpit on the flight home!
Hi all! I'm a researcher at Vanderbilt in Nashville. My lab uses high-throughput methods to study genetic variants, with a focus on ion channels and arrhythmias.
November 20, 2024 at 1:22 AM
Hi all! I'm a researcher at Vanderbilt in Nashville. My lab uses high-throughput methods to study genetic variants, with a focus on ion channels and arrhythmias.