In our new article, we show how P. aeruginosa, a major cause of chronic respiratory infections in #cysticfibrosis (CF), uses the Type VI Secretion System #T6SS and specific #toxins to eliminate competing bacteria
www.cell.com/cell-reports...
#cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social

Thrilled to be one of 12 awardees of the prestigious #ERCStG from the LS1 panel this year! Over the next five years, we’ll study how intracellular bacterial pathogens #Listeria and #Shigella manipulate #actin to spread infection, with the aim of finding ways to stop them. Exciting times ahead!

#Pseudomonas aeruginosa destroys other #bacteria using #T6SS and its effectors during infection in #cysticfibrosis patients. Here, we determined the #cryo-EM #structure of the effector Ptx2, which depolarizes target bacterial membranes.

Check it out!

www.biorxiv.org/content/10.1...

Unexpectedly, this binding site is nearly identical to the one of #Lifeact - the most popular probe for visualization of actin in living cells!

Using cryo-EM 🔬, we determined the structure of the F-tractin–F-actin complex at high resolution. We found its specific binding site, which explained its actin-binding properties!

Check out these structural insights! 📸