Hey #AAIC25 !
Today I'll be sharing our research on the mediating effect of WMH on spontaneous brain activity during aging! 🧠
Join me on poster 430!
@ameliemetz.bsky.social @dadarmahsa.bsky.social @yasharneuro.bsky.social @roqamoqa.bsky.social

Finally, we explored cognitive functioning with the data included in the UKBB dataset. We found that TIV played a role mainly in the cognitive domains of “verbal and numerical reasoning” and “working memory”. 7/10

We asked if brain allometry was affected by sex and/or age. We found that it was consistent across our sample’s age range and between sexes, and followed a similar pattern across brain sizes. 6/10

Projected onto functional connectivity networks, the three measures follow the same pattern; for the cytoarchitectonic classes, volume and CT are similar while SA seems to be balanced for most of the classes. 5/10

We ran the same analyses at the vertex level and found that volume and surface area (SA) are impacted by head size in the same direction as regional volumes, however cortical thickness (CT) is less impacted and in the opposite direction. 4/10

We first asked if females and males had different aging trajectories. In the not matched🔴 sample, all the estimations for males were large, while TIV matching🟡 showed us subtle and bidirectional sex differences. 3/10

We used the UK Biobank data to create subsamples (N = 11,294, 50%F) that removed (total intracranial volume [TIV] and age matched 🟡), maintained (not matched 🔴), or exaggerated (extreme) the TIV differences between sexes. 2/10