Pooja Swali @poojaswali.bsky.social presenting her very interesting work on ancient pathogens. @ugiatucl.bsky.social

Two that I have pictures for, from UCL. Finley Grover presenting his work on the signatures of local adaptation in mtDNA in humans. @ugiatucl.bsky.social

10/ If true, this has the potential to drive or exacerbate micronutrient-linked health disparities across populations - especially when over-farming and climate change continues to decrease soil quality. It is hard to ignore potential public/global health connotations🌎

9/ Why is this important? We suggest dietary micronutrients have shaped the recent evolution of humans and likely contributed to population differentiation in diet-related genes - possibly resulting in average differences in their micronutrient uptake, metabolism or regulation.

8/ In some cases, signatures of positive selection are identified in areas of the world with soil of known deficiencies or toxicities of micronutrients - potentially reflecting genetic adaptation to soil-driven micronutrient levels in the diet. Read our paper to see where 🤓

6/ We used methods informed by extensive simulations to identify signatures of positive selection in ~300 genes associated with 13 essential trace minerals in 40 diverse human populations, considering monogenic, oligogenic and polygenic selection 🧬

5/ We wanted to ask: have all micronutrients acted as selective pressures? Or only a few? And in which populations and timepoints? Is this likely to be driven by differing micronutrient levels in local soils? 🌎